{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:28:22Z","timestamp":1766413702173,"version":"3.48.0"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Objetivos. Identificar los genotipos de Plasmodium vivax en poblaci\u00f3n gestante, y no gestante y explorar su asociaci\u00f3n con mediadores inmunes. Materiales y\u00a0 m\u00e9todos. Se siguieron durante 120 d\u00edas dos cohortes de\u00a0 pacientes con malaria vivax no complicada en Puerto\u00a0 Libertador y Tierralta, C\u00f3rdoba, Colombia: 41 gestantes y 46 no gestantes, todas tratadas con el tratamiento\u00a0 est\u00e1ndar. Se compararon los genotipos parasitarios\u00a0 (microsat\u00e9lites Pv3.27, Pv3.502 y Pv1.501) y la expresi\u00f3n\u00a0 de mediadores inmunes del hospedero (IL-13, IL-10,\u00a0 TNF-alfa, IFN-gamma, IL-8, TGF-beta, Fox-P3, PD-L1)\u00a0 entre infecciones primarias y recurrentes. Resultados. La frecuencia de recurrencias fue mayor en gestantes\u00a0 (41,6%), que en no gestantes (8,7%). La diversidad\u00a0 gen\u00e9tica parasitaria fue mayor en gestantes, aunque sinalelos exclusivos. Las recurrencias fueron gen\u00e9ticamente hom\u00f3logas (mismos alelos) solo en 23% y 33% de los casos en gestante y no gestantes, respectivamente. En cuanto a los mediadores inmunes, solo la expresi\u00f3n de Fox-P3 vari\u00f3 significativamente en gestantes, con mayor expresi\u00f3n en el episodio primario que en el recurrente. Conclusiones. Las mujeres embarazadas est\u00e1n\u00a0 expuestas a una alta frecuencia de recurrencias de\u00a0 malaria vivax, con alta variaci\u00f3n gen\u00e9tica del par\u00e1sito, lo que puede afectar el desarrollo de inmunidad protectora efectiva y favorecer desenlaces obst\u00e9tricos adversos, tanto maternos como neonatales. Estos hallazgos plantean la necesidad de fortalecer y optimizar las acciones de prevenci\u00f3n y tratamiento de la malaria vivax durante la gestaci\u00f3n.<\/jats:p>","DOI":"10.17843\/rpmesp.2025.424.14865","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:23:48Z","timestamp":1766413428000},"page":"389-99","source":"Crossref","is-referenced-by-count":0,"title":["Parasite genotypes and host immune mediators in primary and recurrent &lt;i&gt;Plasmodium vivax&lt;\/i&gt; malaria episodes in Colombia","Genotipos parasitarios y mediadores inmunes del hospedero en episodios\u00a0 primarios y recurrentes de la malaria vivax en Colombia"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7141-5196","authenticated-orcid":false,"given":"Yesica Yamile","family":"Duque-Isaza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0428-9887","authenticated-orcid":false,"given":"Jaime","family":"Carmona-Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5407-7642","authenticated-orcid":false,"given":"Eliana Mar\u00eda","family":"Arango-Fl\u00f3rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2025,12,13]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14865\/6085","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14865\/6085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:23:51Z","timestamp":1766413431000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/14865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,13]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2025.424.14865","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,13]]}}}