{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:28:22Z","timestamp":1766413702254,"version":"3.48.0"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Objectives. To assess whether there is an association between current major depressive episode (CMDE) andmenstrual irregularities (MI)\u2014including amenorrhea, oligomenorrhea, or polymenorrhea\u2014among Peruvianfemale university students in 2024. Materials and methods. An observational, cross-sectional, analytical study was conducted among students from a private university in Lima, Peru. The Patient Health Questionnaire\u20139\u00a0 (PHQ-9) was used to identify CMDE, and a structured questionnaire with closed-ended questions was used to identify cases of MI. The measure of association was the prevalence ratio (PR), estimated using Poisson regression models, both crude and\u00a0 adjusted for potential confounding factors. Results. A\u00a0 total of 250 women aged 18\u201330 years participated\u00a0 (median age: 20 years; interquartile range, 19\u201321 years). Overall, 73.2% presented at least one MI (amenorrhea, oligomenorrhea, or polymenorrhea), and 70.8% had CMDE of any severity (29.2% mild and 41.6% moderate-to-severe). Compared with students without CMDE, the occurrence of any MI was more likely among those with moderate-to-severe CMDE (adjusted prevalence ratio [aPR] = 1.33; 95% CI: 1.08\u20131.62; p = 0.006), but did not differ with respect to those with mild CMDE (aPR = 1.20; 95% CI: 0.95\u20131.50; p = 0.112). Conclusions. Both MI and CMDE were frequent among university students.\u00a0 Moderate-to-severe CMDE was associated with a higher risk of MI, whereas mild CMDE was not. Future longitudinal studies are warranted to establish temporality and other key aspects for evaluating a potential causal relationship between MI and CMDE,including type-specific menstrual irregularities.<\/jats:p>","DOI":"10.17843\/rpmesp.2025.424.14992","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:23:48Z","timestamp":1766413428000},"page":"400-8","source":"Crossref","is-referenced-by-count":0,"title":["Asociaci\u00f3n entre el episodio depresivo mayor actual y la ocurrencia de irregularidades menstruales en los \u00faltimos seis meses en estudiantes de una universidad privada de Lima, Per\u00fa, 2024","Association between current major depression episode and the occurrence of menstrual irregularities in the last six months in students from a private university in Lima, Peru, 2024"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3476-8871","authenticated-orcid":false,"given":"Ximena","family":"Pantoja-Coronel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0737-2653","authenticated-orcid":false,"given":"Gianella","family":"Castill\u00f3n-V\u00e9liz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9823-1338","authenticated-orcid":false,"given":"Valeria","family":"Ninanya-Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3759-5195","authenticated-orcid":false,"given":"Gema","family":"Roca Terry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3880-4573","authenticated-orcid":false,"given":"Yvana","family":"Morales-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9158-443X","authenticated-orcid":false,"given":"Fabi\u00e1n","family":"Fiestas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2025,12,11]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14992\/6081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14992\/6081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:23:51Z","timestamp":1766413431000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/14992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2025.424.14992","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,11]]}}}