{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:28:23Z","timestamp":1766413703307,"version":"3.48.0"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Las esponjas marinas constituyen una fuente reconocida de metabolitos con potencial actividad antibacteriana. En el presente estudio se evalu\u00f3 la actividad antibacteriana de la esponja marina Suberites aff. latus de Ica, Per\u00fa. Las muestras de esponja liofilizadas se\u00a0 extrajeron utilizando diclorometano:metanol (1:1), y se\u00a0 fraccionaron mediante extracci\u00f3n en fase s\u00f3lida en siete fracciones (F1\u2013F7), que iban de la polaridad acuosa a laorg\u00e1nica. Se determin\u00f3 la concentraci\u00f3n m\u00ednima inhibitoria frente a cepas bacterianas Grampositivas\/negativas de colecci\u00f3n ATCC (American Type Culture Collection). Los resultados mostraron que la mayor actividad fue observada en la fracci\u00f3n F6 del esp\u00e9cimen 01J frente a Klebsiella pneumoniae y Pseudomonas aeruginosa, as\u00ed como en la fracci\u00f3n F3 del esp\u00e9cimen 02J frente a K. pneumoniae. El an\u00e1lisis\u00a0 qu\u00edmico cualitativo revel\u00f3 la presencia de alcaloides y saponinas en las muestras. Estos hallazgos ponen de relieve el potencial de Suberites aff. latus de la costa peruana como fuente prometedora de compuestos antibacterianos.<\/jats:p>","DOI":"10.17843\/rpmesp.2025.424.15003","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:23:48Z","timestamp":1766413428000},"page":"424-9","source":"Crossref","is-referenced-by-count":0,"title":["Antibacterial activity &lt;i&gt;in vitro&lt;\/i&gt; of extracts and purified fractions from the marine sponge &lt;i&gt;Suberites&lt;\/i&gt; aff. &lt;i&gt;latus&lt;\/i&gt; (Demospongiae, Suberitida, Suberitidae) from Ica, Peru","Actividad antibacteriana &lt;i&gt;in vitro&lt;\/i&gt; de extractos y fracciones purificadas de la esponja marina &lt;i&gt;Suberites&lt;\/i&gt; aff. &lt;i&gt;latus&lt;\/i&gt; (Demospongiae, Suberitida, Suberitidae) de Ica, Per\u00fa"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4852-9897","authenticated-orcid":false,"given":"Erin","family":"Villanueva-Coronado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5095-6623","authenticated-orcid":false,"given":"Juan C.","family":"Francia-Quiroz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6775-8156","authenticated-orcid":false,"given":"Christian","family":"Polo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9773-2176","authenticated-orcid":false,"given":"Oscar","family":"Reategui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7832-7319","authenticated-orcid":false,"given":"B\u00e1slavi","family":"C\u00f3ndor-Luj\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8502-8755","authenticated-orcid":false,"given":"Aldo G.","family":"Indacochea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria J.","family":"Pons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2025,12,13]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/15003\/6086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/15003\/6086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:23:53Z","timestamp":1766413433000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/15003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,13]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2025.424.15003","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,13]]}}}