{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:28:23Z","timestamp":1766413703388,"version":"3.48.0"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>La Enfermedad de Parkinson (EP) es el trastorno neurodegenerativo de m\u00e1s r\u00e1pido crecimiento mundial. Se determinaron las caracter\u00edsticas cl\u00ednicas de adultos\u00a0 con EP en un hospital de referencia regional en Arequipa, mediante un estudio descriptivo y transversal\u00a0 realizado entre junio de 2023 y enero de 2025. Se incluyeron 60 adultos con EP (20 mujeres), la edad\u00a0 promedio fue de 64,4 a\u00f1os. El fenotipo motor m\u00e1s frecuente fue el tremolante (73,3%). Todos recib\u00edan\u00a0 tabletas con 250 mg de levodopa y 25 mg de carbidopa. La mitad tomaba entre 250 y 750 mg de levodopa al d\u00eda y el 21% presentaba discinesias. Los s\u00edntomas no motores m\u00e1s frecuentes fueron la ansiedad (93,2%), la depresi\u00f3n (88,6%) y el deterioro cognitivo leve (&gt;60%). Estos\u00a0 hallazgos resaltan la oportunidad de optimizar el\u00a0 tratamiento de s\u00edntomas motores y no motores con terapias farmacol\u00f3gicas y no farmacol\u00f3gicas enfocadas en mejorar la calidad de vida de los pacientes con EP residentes en la regi\u00f3n Arequipa.<\/jats:p>","DOI":"10.17843\/rpmesp.2025.424.15105","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:23:48Z","timestamp":1766413428000},"page":"430-5","source":"Crossref","is-referenced-by-count":0,"title":["Caracter\u00edsticas cl\u00ednicas de la enfermedad de Parkinson\u00a0 en consulta externa de un\u00a0 hospital regional en Per\u00fa","Clinical characteristics of Parkinson's disease in the outpatient clinic of a regional hospital in Peru"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6395-2143","authenticated-orcid":false,"given":"Jos\u00e9 Junior","family":"Centeno Arispe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1622-9208","authenticated-orcid":false,"given":"Carlos Alberto","family":"Hurtado Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0971-0603","authenticated-orcid":false,"given":"Alan Patricio","family":"Murillo Salas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5979-6048","authenticated-orcid":false,"given":"Isabel Paola","family":"Camargo Salazar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9766-6252","authenticated-orcid":false,"given":"Karlo John","family":"Lizarraga Mendoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2025,12,13]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/15105\/6087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/15105\/6087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:23:53Z","timestamp":1766413433000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/15105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,13]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2025.424.15105","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,13]]}}}