{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:55:52Z","timestamp":1791237352786,"version":"4.1.0"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>El s\u00edndrome de Lyell (SL) es una reacci\u00f3n adversa cut\u00e1nea grave inducida por f\u00e1rmacos, asociada a alta morbilidad y mortalidad. Se presenta el caso de un var\u00f3n de 41 a\u00f1os que, tras el uso de medicamentos t\u00f3picos, desarroll\u00f3 fiebre, lesiones maculopapulares, compromiso ocular y mucoso, con afectaci\u00f3n de m\u00e1s del 30% del \u00e1rea de superficie corporal. La biopsia cut\u00e1nea\u00a0 descart\u00f3 otras patolog\u00edas. El manejo incluy\u00f3\u00a0 metilprednisolona sist\u00e9mica, subacetato de aluminio,\u00a0 mupirocina t\u00f3pica, prednisolona oft\u00e1lmica e hipromelosa oft\u00e1lmica, con evoluci\u00f3n favorable y sin complicaciones.\u00a0 Este caso resalta la importancia de considerar a los\u00a0 medicamentos t\u00f3picos como posibles desencadenantes\u00a0 de SL as\u00ed como la necesidad de un diagn\u00f3stico precoz y manejo oportuno. La identificaci\u00f3n temprana y un\u00a0 enfoque terap\u00e9utico multidisciplinario son fundamentales para mejorar los resultados cl\u00ednicos y reducir la morbimortalidad asociadas a esta entidad.<\/jats:p>","DOI":"10.17843\/rpmesp.2026.433.15468","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:12:11Z","timestamp":1791234731000},"page":"402-7","source":"Crossref","is-referenced-by-count":0,"title":["S\u00edndrome de Lyell asociado al uso de agentes de aplicaci\u00f3n t\u00f3pica: reporte de caso","Lyell\u00b4 s syndrome associated with the use of topical agents: case report"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0971-0603","authenticated-orcid":false,"given":"Alan P.","family":"Murillo-Salas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9698-7261","authenticated-orcid":false,"given":"Estephania B.","family":"D\u00edaz-Panuera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9382-2402","authenticated-orcid":false,"given":"Francheska M.","family":"N\u00fa\u00f1ez-Gonzales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3533-6969","authenticated-orcid":false,"given":"Aira S.","family":"Ch\u00e1vez-Panuera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3965-8914","authenticated-orcid":false,"given":"Fabi\u00e1n L.","family":"Cuba-Pacheco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6549-9628","authenticated-orcid":false,"given":"Mar\u00eda F.","family":"Bernales-Valdivia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7920","published-online":{"date-parts":[[2026,8,4]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/15468\/6255","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/15468\/6302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/15468\/6255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:12:22Z","timestamp":1791234742000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/15468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,4]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2026.433.15468","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,4]]}}}