{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:56:36Z","timestamp":1791237396995,"version":"4.1.0"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Lactoferrin (LF) is a glycoprotein with antimicrobial and immunomodulatory properties that is present in human\u00a0 milk and plays a fundamental role in infant protection.\u00a0 The objective was to describe LF concentration during\u00a0 the first postpartum year in Northern Lima, Peru. A\u00a0 retrospective observational study was conducted based\u00a0 on a secondary analysis of 158 human milk samples\u00a0 from 83 mothers: 39 transition milk samples (7\u201314 days)\u00a0 and 119 mature milk samples (2\u201312 months). LF was quantified using ELISA. The median LF concentration in transition milk was 6.52 (IQR: 5.16\u20138.15) mg\/mL and in mature milk was 1.01 (IQR: 0.80\u20131.57) mg\/mL. During\u00a0 the mature milk periods, the values were 3.33 mg\/mL (2\u00a0 months), 3.27 mg\/mL (3\u20135 months), 2.56 mg\/mL (6\u20137 months), and 2.08 mg\/mL (8\u201312 months). Among the 22 mothers with paired samples, the mean concentration\u00a0 was 7.71 \u00b1 2.27 mg\/mL in transition milk and 3.76 \u00b1 1.06\u00a0 mg\/mL at 2 months. The lack of sufficient colostrum samples and the uneven availability of samples limit the complete characterization of the trajectory during the\u00a0 first year. The results describe a decreasing pattern in LF concentration throughout the first year of lactation.<\/jats:p>","DOI":"10.17843\/rpmesp.2026.433.16525","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:12:11Z","timestamp":1791234731000},"page":"371-8","source":"Crossref","is-referenced-by-count":0,"title":["Concentraci\u00f3n de lactoferrina en leche materna durante el primer a\u00f1o posparto en Lima Norte, Per\u00fa","Lactoferrin concentration in human milk during the first year postpartum in Lima Norte, Peru"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-3210","authenticated-orcid":false,"given":"Edison A.","family":"Rivera-Fernandez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9296-2850","authenticated-orcid":false,"given":"David","family":"Durand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6099-7509","authenticated-orcid":false,"given":"Rafaella","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5149-4950","authenticated-orcid":false,"given":"Yamile","family":"Rodriguez-Angeles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5208-0933","authenticated-orcid":false,"given":"Pia S.","family":"Pannaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3227-3906","authenticated-orcid":false,"given":"Theresa J.","family":"Ochoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7920","published-online":{"date-parts":[[2026,9,25]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/16525\/6315","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/16525\/6315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:12:19Z","timestamp":1791234739000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/16525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2026.433.16525","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,25]]}}}