{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:14:53Z","timestamp":1777392893504,"version":"3.51.4"},"reference-count":0,"publisher":"Touch Medical Media, Ltd.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>\n                    Central precocious puberty (CPP) results from premature re-activation of the gonadotropic axis. CPP is much more common in girls than in boys and is idiopathic in most cases. In boys, precocious puberty is more likely to be linked to hypothalamic lesions (\u224840%). Recent studies have implicated the inactivation of\n                    <jats:italic>MKRN3<\/jats:italic>\n                    gene in \u2018idiopathic\u2019 CPP. Gonadotropin-releasing hormone agonists are the standard treatment for progressive CPP.\n                  <\/jats:p>","DOI":"10.17925\/ee.2015.11.01.45","type":"journal-article","created":{"date-parts":[[2015,6,20]],"date-time":"2015-06-20T05:59:46Z","timestamp":1434779986000},"page":"45","source":"Crossref","is-referenced-by-count":4,"title":["Central Precocious Puberty \u2013 Management and Long-term Outcomes"],"prefix":"10.17925","volume":"11","author":[{"given":"Juliane","family":"L\u00e9ger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Robert Debr\u00e9, Service d\u2019Endocrinologie Diab\u00e9tologie P\u00e9diatrique, Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance, F-75019 Paris, France","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, F-75019 Paris, France","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (Inserm), Unit\u00e9 1141, DHU Protect, F-75019 Paris, France","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7274","container-title":["European Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/touchendocrinology.com\/pediatric-endocrinology\/journal-articles\/central-precocious-puberty-management-and-long-term-outcomes\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T07:00:41Z","timestamp":1764745241000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.touchendocrinology.com\/articles\/central-precocious-puberty-management-and-long-term-outcomes"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014]]}},"alternative-id":["EE.2015.11.01.45"],"URL":"https:\/\/doi.org\/10.17925\/ee.2015.11.01.45","relation":{},"ISSN":["1758-3772"],"issn-type":[{"value":"1758-3772","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}