{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T07:05:43Z","timestamp":1764745543802,"version":"3.46.0"},"reference-count":0,"publisher":"Touch Medical Media, Ltd.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Over the past two decades, we have studied various parathyroid hormone (PTH) 1-34 regimens, including once-daily and twice-daily injections without the concurrent conventional therapy. We recently studied PTH delivery by insulin pump, which produced normal, steady-state serum and urine calcium levels. The recent approval of PTH 1-84 represents an important milestone in the treatment of hypoparathyroidism. As PTH 1-84 and PTH 1-34 have similar pharmacokinetic (PK) and pharmacodynamic profiles, one can assume that many of the principles learned from studies of PTH 1-34 also apply to PTH 1-84 in the management of this rare disease.<\/jats:p>","DOI":"10.17925\/ee.2016.12.01.47","type":"journal-article","created":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T18:09:26Z","timestamp":1458151766000},"page":"47","source":"Crossref","is-referenced-by-count":0,"title":["Perspectives on the Search for a True Physiologic Replacement Therapy for Hypoparathyroidism"],"prefix":"10.17925","volume":"12","author":[{"given":"Karen K","family":"Winer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"NICHD, National Institutes of Health, Bethesda, Maryland, US","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7274","container-title":["European Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/touchendocrinology.com\/thyroid\/journal-articles\/perspectives-on-the-search-for-a-true-physiologic-replacement-therapy-for-hypoparathyroidism\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T07:00:32Z","timestamp":1764745232000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.touchendocrinology.com\/articles\/perspectives-search-true-physiologic-replacement-therapy-hypoparathyroidism"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016]]}},"alternative-id":["EE.2016.12.01.47"],"URL":"https:\/\/doi.org\/10.17925\/ee.2016.12.01.47","relation":{},"ISSN":["1758-3772"],"issn-type":[{"type":"print","value":"1758-3772"}],"subject":[],"published":{"date-parts":[[2016]]}}}