{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T07:05:25Z","timestamp":1764745525394,"version":"3.46.0"},"reference-count":0,"publisher":"Touch Medical Media, Ltd.","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>After many years of limited therapeutic opportunities, the treatment of type 2 diabetes has become more target and pathophysiologically driven. A typical example is represented by the development of the dipeptidyl peptidase-4 (DPP-4) inhibitors, allowing for more physiological regulation of the endocrine pancreas and leading to a previously unmet risk-to-benefit balance. Vildagliptin, one of the earliest DPP-4 inhibitors, has been tested across the entire spectrum of type 2 diabetes and has been in clinical use for 20 years. This publication critically reviews the main steps in the clinical development of this agent.<\/jats:p>","DOI":"10.17925\/ee.2017.13.02.54","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T07:44:35Z","timestamp":1505288675000},"page":"54","source":"Crossref","is-referenced-by-count":0,"title":["Ten Years of Vildagliptin"],"prefix":"10.17925","volume":"13","author":[{"given":"Stefano Del","family":"Prato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7274","container-title":["European Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/touchendocrinology.com\/diabetes\/journal-articles\/ten-years-of-vildagliptin\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T07:00:19Z","timestamp":1764745219000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.touchendocrinology.com\/articles\/ten-years-vildagliptin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":0,"journal-issue":{"issue":"02","published-print":{"date-parts":[[2017]]}},"alternative-id":["EE.2017.13.02.54"],"URL":"https:\/\/doi.org\/10.17925\/ee.2017.13.02.54","relation":{},"ISSN":["1758-3772"],"issn-type":[{"type":"print","value":"1758-3772"}],"subject":[],"published":{"date-parts":[[2017]]}}}