{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:07:31Z","timestamp":1790863651064,"version":"4.1.0"},"reference-count":51,"publisher":"Touch Medical Media, Ltd.","issue":"2","license":[{"start":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T00:00:00Z","timestamp":1518739200000},"content-version":"vor","delay-in-days":46,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"abstract":"<p>The definition of male hypogonadism, used in adult endocrinology, is not fully applicable to paediatrics. A clear understanding of the developmental physiology of the hypothalamic-pituitary-testicular axis is essential for the comprehension of the pathogenesis of hypogonadal states in boys and for the establishment of adequate definitions and classifications in paediatric ages. This is particularly true for central hypogonadism, usually called hypogonadotropic in adults. Because childhood is a period characterised by a physiological state of low gonadotropin and testosterone production, these markers of hypogonadism, typically used in adult endocrinology, are uninformative in the child. This review is focused on the physiological importance of prepubertal Sertoli cell markers \u2013 anti-M\u00fcllerian hormone (AMH) and inhibin B \u2013 and of the intratesticular actions of follicle-stimulating hormone (FSH) and testosterone during early infancy and the first stages of pubertal development. We discuss the role of FSH in regulating the proliferation of Sertoli cells \u2013 the main determinant of prepubertal testicular volume \u2013 and the secretion of AMH and inhibin B. We also address how intratesticular testosterone concentrations have different effects on the seminiferous tubule function in early infancy and during pubertal development.<\/p>","DOI":"10.17925\/ee.2018.14.2.67","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T11:52:30Z","timestamp":1537271550000},"page":"67","source":"Crossref","is-referenced-by-count":24,"title":["Male Central Hypogonadism in Paediatrics \u2013 the Relevance of Follicle-stimulating Hormone and Sertoli Cell Markers"],"prefix":"10.17925","volume":"14","author":[{"given":"Romina P","family":"Grinspon","sequence":"first","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE), National Scientific and Technical Research Council (CONICET) \u2013 Fundaci\u00f3n de Endocrinolog\u00eda Infantil (FEI) \u2013 Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela","family":"Urrutia","sequence":"first","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE), National Scientific and Technical Research Council (CONICET) \u2013 Fundaci\u00f3n de Endocrinolog\u00eda Infantil (FEI) \u2013 Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo A","family":"Rey","sequence":"first","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE), National Scientific and Technical Research Council (CONICET) \u2013 Fundaci\u00f3n de Endocrinolog\u00eda Infantil (FEI) \u2013 Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez, Buenos Aires, Argentina"},{"name":"Departamento de Histolog\u00eda, Biolog\u00eda Celular, Embriolog\u00eda y Gen\u00e9tica, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7274","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Bhasin S, Brito JP, Cunningham GR, et al. 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