{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:52:40Z","timestamp":1774479160414,"version":"3.50.1"},"reference-count":7,"publisher":"Touch Medical Media, Ltd.","issue":"1","license":[{"start":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T00:00:00Z","timestamp":1518739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"This article is published under the Creative Commons Attribution Non-commercial License."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"abstract":"<p>Van Wyk\u2013Grumbach syndrome is a rare, female juvenile hypothyroidism disorder that is characterized by precocious puberty with clinical, radiological and hormonal pathologies. We present a case series of three patients with this unusual condition who were evaluated and followed up over a 3-year period between January 2017 and June 2020. All three patients presented with short stature (&lt;3rd centile), low weight (&lt;3rd centile), absence of goitre, no axillary or pubic hair, delayed bone age by more than 2 years, elevated thyroid-stimulating hormone with low T3 and T4 (primary hypothyroidism), and raised follicle-stimulating hormone with pre-pubertal levels of luteinizing hormone. Abdominal ultrasonography showed bilateral multi-cystic ovaries in two patients and a right-sided bulky ovary in the third patient. One of the patients also had a pituitary \u2018macroadenoma\u2019. All the patients were successfully managed with levothyroxine. We discuss the pathophysiological mechanisms with a brief literature review.<\/p>","DOI":"10.17925\/ee.2023.19.1.98","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T12:40:19Z","timestamp":1685709619000},"page":"98","source":"Crossref","is-referenced-by-count":2,"title":["The Clinical Septet of Van Wyk\u2013Grumbach Syndrome: A Case Series from a Tertiary Care Centre in Kalyana Karnataka, India"],"prefix":"10.17925","volume":"19","author":[{"given":"Swaraj","family":"Waddankeri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Mahadevappa Rampure Medical College, Kalaburagi, Karnataka, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenakshi","family":"Waddankeri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Mahadevappa Rampure Medical College, Kalaburagi, Karnataka, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shrikant","family":"Waddankeri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Mahadevappa Rampure Medical College, Kalaburagi, Karnataka, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kshitij","family":"Arora","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Mahadevappa Rampure Medical College, Kalaburagi, Karnataka, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7274","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Rastogi A, Bhadada SK, Bhansali A. An unusual presentation of a usual disorder: Van Wyk-Grumbach syndrome.\n                      Indian J Endocrinol Metab\n                      . 2011;15:141\u20133.","DOI":"10.4103\/2230-8210.83356"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Sneha LM, Thanasegarapandian K, Paramasivam V, et al. Short stature and an interesting association.\n                      Indian J Hum Genet\n                      . 2013;19:101\u20133.","DOI":"10.4103\/0971-6866.112919"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Durbin KL, Diaz-Montes T, Loveless MB. Van Wyk-Grumbach syndrome: An unusual case and review of literature.\n                      J Pediatr Adolesc Gynecol\n                      . 2011;24:e93\u20136.","DOI":"10.1016\/j.jpag.2010.08.003"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Wormsbecker A, Clarson C. Acquired primary hypothyroidism: Vaginal bleeding in a quiet child.\n                      Can Med Assoc J\n                      . 2010;182:588\u201399.","DOI":"10.1503\/cmaj.090883"},{"key":"ref5","unstructured":"Cetinkaya S, Sagsak E, Erdeve S, et al. Premature menarche associated with Hashimoto thyroiditis at 2 years 9 months: Case report.\n                      J Thyroid Disorders Ther\n                      . 2014;3:159."},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Baranowski E, H\u00f6gler W. An unusual presentation of acquired hypothyroidism: The Van Wyk-Grumbach syndrome.\n                      Eur J Endocrinol\n                      . 2012;166:537\u201342.","DOI":"10.1530\/EJE-11-0494"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Danforth Jr E, Horton ES, O\u2019Connel M, et al. Dietary-induced alterations in thyroid hormone metabolism during overnutrition.\n                      J Clin Invest.\n                      1979;64:1336\u201347.","DOI":"10.1172\/JCI109590"}],"container-title":["European Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/touchendocrinology.com\/pediatric-endocrinology\/journal-articles\/the-clinical-septet-of-van-wyk-grumbach-syndrome-a-case-series-from-a-tertiary-care-centre-in-kalyana-karnataka-india\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T06:59:30Z","timestamp":1764745170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.touchendocrinology.com\/pediatric-endocrinology\/journal-articles\/the-clinical-septet-of-van-wyk-grumbach-syndrome-a-case-series-from-a-tertiary-care-centre-in-kalyana-karnataka-india\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"alternative-id":["EE.2023.19.1.98"],"URL":"https:\/\/doi.org\/10.17925\/ee.2023.19.1.98","relation":{},"ISSN":["1758-3772"],"issn-type":[{"value":"1758-3772","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}