{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T05:19:17Z","timestamp":1794547157718,"version":"4.9.1"},"reference-count":66,"publisher":"Touch Medical Media, Ltd.","issue":"1","license":[{"start":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T00:00:00Z","timestamp":1518739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"This article is published under the Creative Commons Attribution Non-commercial License."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"abstract":"<p>Mitral annular calcification (MAC) is a progressive degenerative calcification of the mitral valve (MV) that is associated with mitral stenosis, regurgitation or both. Patients with MAC are poor candidates for MV surgery because of technical challenges and high peri-operative mortality. Transcatheter MV replacement (TMVR) has emerged as an option for such high surgical risk patients. This has been described with the use of the SAPIEN transcatheter heart valve (valve-in-MAC) and dedicated TMVR devices. Careful anatomic assessment is important to avoid complications of TMVR, such as left ventricular outflow tract obstruction, valve migration, embolization and paravalvular mitral regurgitation. In this review, we discuss the pathology, importance of preprocedural multimodality imaging for optimal patient selection, clinical outcomes and complications associated with TMVR in patients with MAC.<\/p>","DOI":"10.17925\/hi.2023.17.1.19","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T10:16:28Z","timestamp":1688206588000},"page":"19","source":"Crossref","is-referenced-by-count":13,"title":["Transcatheter Mitral Valve Replacement in Patients with Mitral Annular Calcification: A Review"],"prefix":"10.17925","volume":"17","author":[{"given":"Ankit","family":"Agrawal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Reardon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Houston Methodist DeBakey Heart and Vascular Institute, Houston, TX, USA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin S","family":"Goel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Houston Methodist DeBakey Heart and Vascular Institute, Houston, TX, USA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7274","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Yadgir S, Johnson CO, Aboyans V, et al. 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Available at: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03039855 (accessed date: 13 March 2023)."}],"container-title":["Heart International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/touchcardio.com\/cardiovascular-disease\/journal-articles\/transcatheter-mitral-valve-replacement-in-patients-with-mitral-annular-calcification-a-review\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T06:58:13Z","timestamp":1764745093000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.touchcardio.com\/devices\/journal-articles\/transcatheter-mitral-valve-replacement-in-patients-with-mitral-annular-calcification-a-review\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"alternative-id":["HI.2023.17.1.19"],"URL":"https:\/\/doi.org\/10.17925\/hi.2023.17.1.19","relation":{},"ISSN":["2036-2579"],"issn-type":[{"value":"2036-2579","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}