{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T07:14:12Z","timestamp":1764746052637,"version":"3.46.0"},"reference-count":0,"publisher":"Touch Medical Media, Ltd.","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Since platelets possess A and B antigen, mismatched ABO platelets could, theoretically, become activated or hypofunctional by exposure to anti-A or anti-B antibodies found in transfused or recipient plasma. Following normal baseline platelet aggregation to adenosine diphosphate (ADP), platelets from normal donors of different blood types were incubated at 37\u00b0C for 10 minutes with 50\u03bcl of normal saline (NS), O plasma, or AB plasma. Aggregation was then induced with ADP. No significant changes from baseline were seen in platelet aggregation studies following incubation with NS. However, platelet aggregations of type A and type B platelets were significantly inhibited when incubated with O plasma (mean of 41 and 22%, respectively). Our findings indicate that mediators in group O plasma, very likely anti-A and anti-B antibodies, cause impaired platelet aggregation of ABO non-identical platelets.<\/jats:p>","DOI":"10.17925\/ohr.2011.07.1.72","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T15:59:23Z","timestamp":1444406363000},"page":"72","source":"Crossref","is-referenced-by-count":0,"title":["Platelet Activation Following Exposure to Anti-ABO Antibodies\u2014 An In Vitro Study"],"prefix":"10.17925","volume":"07","author":[{"suffix":"MD","given":"Majed A","family":"Refaai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MT(ASCP)","given":"Kelly F","family":"Henrichs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"PhD","given":"Sherry L","family":"Spinelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"PhD","given":"Richard P","family":"Phipps","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MT(ASCP)","given":"Edward","family":"Masel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MT(ASCP)","given":"Brian H","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD","given":"Charles W","family":"Francis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD","given":"Neil","family":"Blumberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Assistant Professor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Medical Technologist Specialist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Research Associate Professor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Dean\u2019s Professor of Environmental Medicine, Oncology, Pediatrics, and Microbiology and Immunology","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Medical Technologist Specialist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Medical Technologist Specialist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Professor Emeritus, Department of Medicine, and Professor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Professor, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7274","container-title":["Oncology &amp; Hematology Review (US)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/touchoncology.com\/haematology\/journal-articles\/platelet-activation-following-exposure-to-anti-abo-antibodies-an-in-vitro-study\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T07:08:57Z","timestamp":1764745737000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.touchoncology.com\/articles\/platelet-activation-following-exposure-anti-abo-antibodies-vitro-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":0,"journal-issue":{"issue":"01","published-print":{"date-parts":[[2011]]}},"alternative-id":["OHR.2011.07.1.72"],"URL":"https:\/\/doi.org\/10.17925\/ohr.2011.07.1.72","relation":{},"ISSN":["2052-3815"],"issn-type":[{"type":"print","value":"2052-3815"}],"subject":[],"published":{"date-parts":[[2011]]}}}