{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T21:41:49Z","timestamp":1722980509641},"reference-count":0,"publisher":"Laeknabladid\/The Icelandic Medical Journal","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LBL"],"published-print":{"date-parts":[[2023,11,6]]},"abstract":"<jats:p>Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare neurological disorder caused by autoimmune antibodies attacking the presynaptic neuromuscular junction, in some cases caused by underlying cancer. The main clinical finding is fluctuating weakness of the extremities and a triad of symtoms can help physicians suspect the disease. A key to the diagnosis are the electrophysiological abnormalities seen in this group of diseases. Treatment with symtomatic and\/or immunosuppressive therapy is important as well as a workup for possible malignancy. This article identifies the clinical features, diagnosis and treatment of this uncommon disease.<\/jats:p>","DOI":"10.17992\/lbl.2023.11.768","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T16:02:50Z","timestamp":1699027370000},"page":"508-512","source":"Crossref","is-referenced-by-count":0,"title":["A 50 year old man with progressive weakness in lower limbs"],"prefix":"10.17992","volume":"109","author":[{"name":"Neurological department Karolinska University Hospital, Stockholm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brynhildur","family":"Thors","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bjarni","family":"Gu\u00f0mundsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Neurology department, Landspitali University Hospital","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7439","published-online":{"date-parts":[[2023,11,6]]},"container-title":["L\u00e6knabla\u00f0i\u00f0"],"original-title":["Vaxandi m\u00e1ttleysi \u00ed ganglimum hj\u00e1 fimmtugum manni  \u2022 Sj\u00fakratilfelli \u2022"],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T16:03:02Z","timestamp":1699027382000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.laeknabladid.is\/tolublod\/2023\/11\/nr\/8454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,6]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11,6]]},"published-print":{"date-parts":[[2023,11,6]]}},"URL":"https:\/\/doi.org\/10.17992\/lbl.2023.11.768","relation":{},"ISSN":["0023-7213","1670-4959"],"issn-type":[{"type":"print","value":"0023-7213"},{"type":"electronic","value":"1670-4959"}],"subject":[],"published":{"date-parts":[[2023,11,6]]}}}