{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T04:23:34Z","timestamp":1744691014924},"reference-count":0,"publisher":"Laeknabladid\/The Icelandic Medical Journal","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LBL"],"published-print":{"date-parts":[[2024,1,5]]},"abstract":"<jats:p>A 72-year-old woman presented to the emergency department due to worsening dyspnea. She had been diagnosed with asthma a year earlier. At arrival, her oxygen saturation was only 84%. During lung auscultation, wheezing was noted over all lung fields. A blood test showed a significant increase in eosinophils in peripheral blood, highest value of 1.4 x 10E9\/L.    Further investigations in the respiratory ward showed a positive MPO-ANCA, which, together with clinical features of asthma, chronic rhinosinusitis with polyps, mononeuritis multiplex and eosinophilia, led to the diagnosis of eosinophilic granulomatosis with polyangiitis, or what used to be called Churg-Strauss syndrome. Corticosteroid treatment was initiated and subsequently tapered down when treatment with mepolizumab was started, which is an IL-5 inhibitor. Her symptoms quickly became much better. Frequent exacerbation and pulmonary symptoms became things of the past.<\/jats:p>","DOI":"10.17992\/lbl.2024.01.777","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T10:41:16Z","timestamp":1704192076000},"page":"28-32","source":"Crossref","is-referenced-by-count":1,"title":["Eosinophilic granulomatosis with polyangiitis, a case report"],"prefix":"10.17992","volume":"110","author":[{"name":"Department of Internal medicine, Landspitali University Hospital","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d3lafur Orri","family":"Sturluson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d3lafur","family":"P\u00e1lsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Rheumatology, Landspitali University Hospital","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Einar","family":"Hjaltested","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Otolaryngology, Landspitali University Hospital","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00f3ra","family":"L\u00fa\u00f0v\u00edksd\u00f3ttir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Pulmonology, Landspitali University Hospital","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7439","published-online":{"date-parts":[[2024,1,5]]},"container-title":["L\u00e6knabla\u00f0i\u00f0"],"original-title":["Sm\u00e1\u00e6\u00f0ab\u00f3lga me\u00f0 rau\u00f0kyrningafj\u00f6ld, EGPA, falinn fylgisj\u00fakd\u00f3mur astma?  \u2022 Sj\u00fakratilfelli \u2022"],"deposited":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T10:41:21Z","timestamp":1704192081000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.laeknabladid.is\/tolublod\/2024\/01\/nr\/8514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,5]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2024,1,5]]},"published-print":{"date-parts":[[2024,1,5]]}},"URL":"https:\/\/doi.org\/10.17992\/lbl.2024.01.777","relation":{},"ISSN":["0023-7213","1670-4959"],"issn-type":[{"type":"print","value":"0023-7213"},{"type":"electronic","value":"1670-4959"}],"subject":[],"published":{"date-parts":[[2024,1,5]]}}}