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As a non-invasive alternative to tissue biopsy, liquid biopsy examines circulating cellular components such as exosomes, nucleic acids, and cell-free DNA found in body fluids (e.g., urine, saliva, ascites, and pleural effusions) and provides information about tumor characteristics. Technical advances in liquid biopsy have led to the increasing adoption of diagnostic and monitoring applications for HCC. This review summarizes the various analytes, ongoing clinical trials, and case studies of United States Food and Drug Administrationapproved in vitro diagnostic applications for liquid biopsy, and provides insight into its implementation in managing HCC.<\/jats:p>","DOI":"10.17998\/jlc.2022.09.08","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T22:17:34Z","timestamp":1663798654000},"page":"103-114","update-policy":"https:\/\/doi.org\/10.17998\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Liquid biopsy for early detection and therapeutic monitoring of hepatocellular carcinoma"],"prefix":"10.17998","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4188-4071","authenticated-orcid":true,"given":"Eun-Ji","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5061-587X","authenticated-orcid":true,"given":"Young-Joon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7328","reference":[{"key":"ref1","volume-title":"Estimated number of deaths in 2020, World, both sexes, all ages (excl. 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