{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:07:04Z","timestamp":1781154424880,"version":"3.54.1"},"reference-count":31,"publisher":"Korean Liver Cancer Association","issue":"1","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000404","name":"Liver Research Foundation of Korea","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000404","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Biocompatibles UK Ltd."}],"content-domain":{"domain":["e-jlc.org"],"crossmark-restriction":true},"short-container-title":["JLC"],"published-print":{"date-parts":[[2023,3,31]]},"abstract":"<jats:p>Background\/Aim: To evaluate the applicability of transarterial chemoembolization (TACE) treatment with doxorubicin drug-eluting beads (DEBs) in advanced hepatocellular carcinoma (HCC) patients with portal vein invasion (PVI).Methods: This prospective study was approved by the institutional review board and informed consent was obtained from all participants. A total of 30 HCC patients with PVI received DEB-TACE between 2015 and 2018. The following parameters were evaluated: complications during DEB-TACE, abdominal pain, fever, and laboratory outcomes, including liver function change. Overall survival (OS), time to progression (TTP), and adverse events were also analyzed and assessed.Results: DEBs measuring 100\u2013300 \u03bcm in diameter were loaded with doxorubicin (150 mg per procedure). There were no complications during DEB-TACE and no significant differences in the levels of prothrombin time, serum albumin, or total bilirubin at follow-up compared to baseline. The median TTP was 102 days (95% confidence interval [CI], 42\u2013207 days) and the median OS was 216 days (95% CI, 160\u2013336 days). Three patients (10%) had severe adverse reactions, including transient acute cholangitis (n=1), cerebellar infarction (n=1), and pulmonary embolism (n=1), but no treatment-related death occurred.Conclusions: DEB-TACE may be a therapeutic option for advanced HCC patients with PVI.<\/jats:p>","DOI":"10.17998\/jlc.2023.02.08","type":"journal-article","created":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T23:12:32Z","timestamp":1678057952000},"page":"166-176","update-policy":"https:\/\/doi.org\/10.17998\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of doxorubicin-eluting bead transarterial chemoembolization for unresectable hepatocellular carcinoma with portal vein invasion: a prospective study"],"prefix":"10.17998","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8888-7977","authenticated-orcid":true,"given":"Su 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