{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:27:01Z","timestamp":1740176821345,"version":"3.37.3"},"reference-count":34,"publisher":"Korean Liver Cancer Association","issue":"2","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016275","name":"Seoul National University Bundang Hospital","doi-asserted-by":"publisher","award":["14-2020-005","02-2022-0008"],"award-info":[{"award-number":["14-2020-005","02-2022-0008"]}],"id":[{"id":"10.13039\/100016275","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean Liver Cancer Association"}],"content-domain":{"domain":["e-jlc.org"],"crossmark-restriction":true},"short-container-title":["JLC"],"published-print":{"date-parts":[[2024,9,30]]},"abstract":"<jats:p>Backgrounds\/Aims: To evaluate the safety and effectiveness of superselective ablative chemo-ethanol embolization (SACE) for the treatment of patients with recurrent single hepatocellular carcinoma (rHCC).Methods: This retrospective study included 22 patients (19 men; median age, 63 years [range, 38-86]) with Child-Pugh class of A\/ B\/C (16\/3\/3) that underwent SACE between January and June 2023 for recurrent single HCCs measuring \u22645 cm in diameter using a mixture of 99% ethanol and ethiodized oil\/doxorubicin emulsion. The primary endpoint was the 6-month tumor response, and the secondary endpoints were the 1-month tumor response and treatment-related safety. This study was approved by our institutional review board, and the requirement for informed consent was waived.Results: SACE was successfully performed in 22 patients (95.2%). The complete response rates at 1-month and 6-month after treatment were 100.0% and 83.3%, respectively. At 6-month, local tumor progression occurred in one patient and intrahepatic distant metastasis was found in six patients (30.0%). No 6-month mortalities were reported. No adverse events greater than grade 2 or laboratory deteriorations were observed. Biliary complications or liver abscesses were not observed.Conclusions: SACE for a single rHCC was highly effective in achieving a favorable 6-month tumor response and showed acceptable adverse events. However, further prospective studies are required to verify these findings.<\/jats:p>","DOI":"10.17998\/jlc.2024.05.08","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T06:16:25Z","timestamp":1715667385000},"page":"217-223","update-policy":"https:\/\/doi.org\/10.17998\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Superselective ablative chemo-ethanol embolization for recurrent single hepatocellular carcinoma: a 6-month outcome analysis"],"prefix":"10.17998","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6513-3224","authenticated-orcid":true,"given":"Jae Hwan","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2018-8130","authenticated-orcid":true,"given":"Kun 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