{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:40:41Z","timestamp":1747201241773,"version":"3.40.5"},"reference-count":0,"publisher":"Ideggyogyaszati Szemle Journal","issue":"9-10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>A migr\u00e9n az els\u0151dleges fejf\u00e1j\u00e1sbetegs\u00e9gek k\u00f6z\u00e9 tartoz\u00f3 gyakori megbeteged\u00e9s, ami nagym\u00e9rt\u00e9kben k\u00e1ros\u00edtja az egy\u00e9n \u00e9letmin\u0151s\u00e9g\u00e9t. Gy\u00f3gyszeres kezel\u00e9s\u00e9ben akut \u00e9s megel\u0151z\u0151 ter\u00e1pi\u00e1kat k\u00fcl\u00f6n\u00edt\u00fcnk el. Az Eur\u00f3pai Fejf\u00e1j\u00e1s T\u00e1rsas\u00e1g \u00e9s az Eur\u00f3pai Neurol\u00f3giai Akad\u00e9mia k\u00f6z\u00f6s ter\u00e1pi\u00e1s aj\u00e1nl\u00e1sa alapj\u00e1n rohamter\u00e1pi\u00e1ban nem kiel\u00e9g\u00edt\u0151 tript\u00e1nv\u00e1lasz eset\u00e9n javasolt tript\u00e1n \u00e9s nem szteroid gyullad\u00e1sg\u00e1tl\u00f3k egy\u00fcttes ad\u00e1sa. Munk\u00e1nkban a fix d\u00f3zis\u00fa szumatript\u00e1n\u2013naprox\u00e9n-n\u00e1trium (85 mg\/500 mg) kombin\u00e1ci\u00f3j\u00fa tabletta haszn\u00e1lat\u00e1val kapcsolatos eredm\u00e9nyeket (hat\u00e1soss\u00e1g, biztons\u00e1goss\u00e1g) tekintj\u00fck \u00e1t randomiz\u00e1lt klinikai vizsg\u00e1latok eredm\u00e9nyei alapj\u00e1n. A fix d\u00f3zis\u00fa szumatript\u00e1n\u2013naprox\u00e9n-n\u00e1trium kombin\u00e1lt farmakon a placeb\u00f3hoz \u00e9s az egyes \u00f6sszetev\u0151kh\u00f6z viszony\u00edtva statisztikailag szignifik\u00e1nsan t\u00f6bb migr\u00e9nes p\u00e1ciensben eredm\u00e9nyezett a gy\u00f3gyszerbev\u00e9telt k\u00f6vet\u0151en 2 \u00f3r\u00e1val teljes fejf\u00e1j\u00e1smentess\u00e9get. Eredm\u00e9nyesen cs\u00f6kkentette a migr\u00e9n k\u00eds\u00e9r\u0151t\u00fcneteit, \u00fagymint a h\u00e1nyingert, valamint a f\u00e9ny- \u00e9s hang\u00e9rz\u00e9kenys\u00e9get. A k\u00e9sz\u00edtm\u00e9nnyel kapcsolatosan \u00e9szlelt leggyakoribb mell\u00e9khat\u00e1s a h\u00e1nyinger \u00e9s a sz\u00e9d\u00fcl\u00e9s\u00e9rz\u00e9s volt, ami ar\u00e1nyaiban megegyezett a placeb\u00f3val. A fix d\u00f3zis\u00fa szumatript\u00e1n\u2013naprox\u00e9nn\u00e1trium kombin\u00e1lt tabletta a migr\u00e9n akut kezel\u00e9s\u00e9ben hat\u00e9kony, j\u00f3l toler\u00e1lhat\u00f3 \u00e9s biztons\u00e1gosan haszn\u00e1lhat\u00f3 farmakon.<\/jats:p>","DOI":"10.18071\/isz.76.0293","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:20:51Z","timestamp":1696245651000},"page":"293-296","source":"Crossref","is-referenced-by-count":0,"title":["Szumatript\u00e1n\u2013naprox\u00e9n-n\u00e1trium fix d\u00f3zis\u00fa kombin\u00e1ci\u00f3ja a migr\u00e9n akut kezel\u00e9s\u00e9ben \u2013 irodalmi \u00e1ttekint\u00e9s"],"prefix":"10.18071","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0857-5266","authenticated-orcid":false,"given":"J\u00e1nos","family":"Tajti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0962-4656","authenticated-orcid":false,"given":"Anett","family":"Cs\u00e1ti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6445-8825","authenticated-orcid":false,"given":"D\u00e9lia","family":"Szok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7411","published-online":{"date-parts":[[2023]]},"container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"original-title":[],"link":[{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/sumatriptan-naproxen-sodium-fix-dose-combination-for-acute-migraine-treatment-a-review\/pdf-open","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:20:52Z","timestamp":1696245652000},"score":1,"resource":{"primary":{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/sumatriptan-naproxen-sodium-fix-dose-combination-for-acute-migraine-treatment-a-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":0,"journal-issue":{"issue":"9-10","published-online":{"date-parts":[[2023]]},"published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.18071\/isz.76.0293","relation":{},"ISSN":["0019-1442","2498-6208"],"issn-type":[{"type":"print","value":"0019-1442"},{"type":"electronic","value":"2498-6208"}],"subject":[],"published":{"date-parts":[[2023]]}}}