{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T10:41:14Z","timestamp":1743158474733,"version":"3.40.3"},"reference-count":0,"publisher":"Ideggyogyaszati Szemle Journal","issue":"3-4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>A fogyat\u00e9koss\u00e1g progresszi\u00f3ja a sclerosis multiplex (SM) minden fenot\u00edpus\u00e1ban\njelentkezhet a betegs\u00e9g korai szakasz\u00e1t\u00f3l\nkezdve, ami a klinikai relapszusokb\u00f3l val\u00f3\nhi\u00e1nyos fel\u00e9p\u00fcl\u00e9sb\u0151l \u00e9s\/vagy a neurol\u00f3giai\nfunkci\u00f3k relapszusokt\u00f3l f\u00fcggetlen, alattomosabban zajl\u00f3 rosszabbod\u00e1s\u00e1b\u00f3l k\u00f6vetkezhet\nbe. A relapszust\u00f3l f\u00fcggetlen rosszabbod\u00e1s\nprogressz\u00edv sclerosis multiplexben gyakoribb,\nmint a relapsz\u00e1l\u00f3-remitt\u00e1l\u00f3 k\u00f3rform\u00e1ban.\nH\u00e1tter\u00e9ben els\u0151sorban a velesz\u00fcletett\nimmunsejtek aktiv\u00e1ci\u00f3ja, kr\u00f3nikus akt\u00edv\nlaesi\u00f3k kialakul\u00e1sa \u00e1llhat, amit par\u00e1zsl\u00f3\nbetegs\u00e9gk\u00e9nt jel\u00f6lnek. Azonos\u00edt\u00e1suk seg\u00edtheti az agressz\u00edv form\u00e1k korai felismer\u00e9s\u00e9t.\nA progressz\u00edv mechanizmusokat c\u00e9lz\u00f3\nhat\u00e9kony ter\u00e1pi\u00e1k megtal\u00e1l\u00e1sa jelent\u0151s\nig\u00e9ny. Az SM progresszi\u00f3j\u00e1nak h\u00e1tter\u00e9ben\n\u00e1ll\u00f3 mechanizmusok jobb meg\u00e9rt\u00e9se, a\nbiomarkerek azonos\u00edt\u00e1sa \u00e9s valid\u00e1l\u00e1sa, az \u00faj\nter\u00e1pi\u00e1s c\u00e9lpontok azonos\u00edt\u00e1sa vezethet a\nter\u00e1pi\u00e1k tov\u00e1bbi siker\u00e9hez. A k\u00f6zlem\u00e9nyben\n\u00f6sszefoglaljuk a par\u00e1zsl\u00f3 betegs\u00e9g elm\u00e9leti\nh\u00e1tter\u00e9t, \u00e9s a felismer\u00e9s\u00e9t c\u00e9lz\u00f3 lehets\u00e9ges\nk\u00e9palkot\u00f3 elj\u00e1r\u00e1sokat.<\/jats:p>","DOI":"10.18071\/isz.77.0079","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T10:06:50Z","timestamp":1743156410000},"page":"79-85","source":"Crossref","is-referenced-by-count":0,"title":["A par\u00e1zsl\u00f3 betegs\u00e9g jelent\u0151s\u00e9ge a sclerosis multiplex progresszi\u00f3j\u00e1ban, a progresszi\u00f3 ellen\u0151rz\u00e9se k\u00e9palkot\u00f3 elj\u00e1r\u00e1s seg\u00edts\u00e9g\u00e9vel"],"prefix":"10.18071","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8433-3485","authenticated-orcid":false,"given":"Lilla","family":"R\u00e1cz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8305-3209","authenticated-orcid":false,"given":"T\u00fcnde","family":"Cs\u00e9p\u00e1ny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7411","published-online":{"date-parts":[[2025]]},"container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"original-title":[],"link":[{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/prognostic-significance-of-smoldering-disease-in-multiple-sclerosis-monitoring-progression-by-imaging\/pdf-open","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T10:06:51Z","timestamp":1743156411000},"score":1,"resource":{"primary":{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/prognostic-significance-of-smoldering-disease-in-multiple-sclerosis-monitoring-progression-by-imaging"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2025]]},"published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.18071\/isz.77.0079","relation":{},"ISSN":["0019-1442","2498-6208"],"issn-type":[{"value":"0019-1442","type":"print"},{"value":"2498-6208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}