{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T15:57:00Z","timestamp":1768924620797,"version":"3.49.0"},"reference-count":0,"publisher":"Ideggyogyaszati Szemle Journal","issue":"11-12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>H\u00e1tt\u00e9r \u00e9s c\u00e9l \u2013 A poszt-Covid \u00e1llapot (m\u00e1sn\u00e9ven long Covid) egy felt\u00e9telezett vagy\nigazolt SARS-CoV-2-infekci\u00f3t k\u00f6vet\u0151en elh\u00faz\u00f3d\u00f3an fenn\u00e1ll\u00f3 t\u00fcnetegy\u00fcttes, ami legal\u00e1bb\n2 h\u00f3napig fenn\u00e1ll, \u00e9s nem magyar\u00e1zhat\u00f3 m\u00e1s\nbetegs\u00e9ggel. Szerte\u00e1gaz\u00f3 t\u00fcnetei k\u00f6z\u00fcl a\nn\u00e9gy leggyakoribb a f\u00e1radts\u00e1g, a diff\u00faz f\u00e1jdalmak, a meger\u0151ltet\u00e9s ut\u00e1ni \u00e1ltal\u00e1nos gyenges\u00e9g \u00e9s az \u201eagyk\u00f6d\u201d (mem\u00f3ria- \u00e9s koncentr\u00e1ci\u00f3s zavar). A long Covid patomechanizmusa\nintenz\u00edv kutat\u00e1sok t\u00e1rgy\u00e1t k\u00e9pezi. C\u00e9lunk\na betegs\u00e9g patomechanizmus\u00e1ra ir\u00e1nyul\u00f3\nkutat\u00e1sokr\u00f3l sz\u00f3l\u00f3 k\u00f6zlem\u00e9nyek \u00e1ttekint\u00e9se\nvolt.\nM\u00f3dszerek \u2013 A PubMed \u00e9s Google Scholar\nadatb\u00e1zisokban a long Covid patomechanizmus\u00e1t t\u00e1rgyal\u00f3, 2019. janu\u00e1r \u00e9s 2024. j\u00fanius\nk\u00f6z\u00f6tt megjelent, magyar \u00e9s angol nyelv\u0171,\neredeti \u00e9s \u00f6sszefoglal\u00f3 k\u00f6zlem\u00e9nyeket tekintett\u00fck \u00e1t.\nEredm\u00e9nyek \u2013 A t\u00fcnetek h\u00e1tter\u00e9ben \u00e1ll\u00f3\npotenci\u00e1lis k\u00f3rokok h\u00e1rom elm\u00e9letbe k\u00f6rvonalaz\u00f3dnak. 1. A \u201elong Covid mint \u00f6n\u00e1ll\u00f3\nneurol\u00f3giai betegs\u00e9g\u201d koncepci\u00f3 \u00e9rtelm\u00e9ben\nt\u00f6bbek k\u00f6z\u00f6tt direkt vir\u00e1lis neuroinv\u00e1zi\u00f3,\napopt\u00f3zis \u00e9s demyelinisati\u00f3s folyamatok\nfelel\u0151sek a t\u00fcnetek\u00e9rt. 2. A \u201elong Covid mint\nsziszt\u00e9m\u00e1s betegs\u00e9g idegrendszeri t\u00fcnete\u201d\na v\u00edrus \u00e1ltal kiv\u00e1ltott elh\u00faz\u00f3d\u00f3 citokin- \u00e9s\nkemokinfelszabadul\u00e1s, illetve l\u00e1tens v\u00edrusfert\u0151z\u00e9sek reaktiv\u00e1ci\u00f3j\u00e1nak megfigyel\u00e9s\u00e9n\nalapul. 3. A \u201elong Covid mint szomatoform\nzavar\u201d elm\u00e9let szerint a betegs\u00e9g oka a\npszichoneuroimmunol\u00f3giai kutat\u00e1sok \u00e9rtelm\u00e9ben a proinflammatorikus citokinh\u00e1l\u00f3zat\nrendellenes aktiv\u00e1ci\u00f3ja k\u00f6vetkezt\u00e9ben l\u00e9trej\u00f6v\u0151 fokozott k\u00f6zponti idegrendszeri szenzitiz\u00e1ci\u00f3. Tanulm\u00e1nyunkban r\u00e1mutatunk arra,\nhogy szoros \u00e1tfed\u00e9s mutatkozik t\u00f6bbek k\u00f6z\u00f6tt a long Covid, a kr\u00f3nikus f\u00e1radts\u00e1g szindr\u00f3ma\/myalgi\u00e1s encephalomyelitis, a DSM-5-\nben \u00f6n\u00e1ll\u00f3 ment\u00e1lis zavark\u00e9nt nem meghat\u00e1rozott, azonban a szakirodalomban elterjedten \u00d6b\u00f6lh\u00e1bor\u00fa-szindr\u00f3mak\u00e9nt eml\u00edtett\nt\u00fcnetegy\u00fcttes, a kr\u00f3nikus Lyme-k\u00f3r, illetve a\nszomatikus t\u00fcnetzavar betegs\u00e9gek k\u00f6z\u00f6tt.\nK\u00f6vetkeztet\u00e9s \u2013 A szerte\u00e1gaz\u00f3, nem specifikus t\u00fcnetekkel jelentkez\u0151 long Covid patomechanizmusa jelenleg ismeretlen, h\u00e1tter\u00e9ben reproduk\u00e1lhat\u00f3, betegs\u00e9gspecifikus\nbiomarkert eddig nem siker\u00fclt kimutatni. Az\nadekv\u00e1t \u00e9s hat\u00e9kony ter\u00e1pi\u00e1s m\u00f3dszerek\nmeghat\u00e1roz\u00e1sa c\u00e9lj\u00e1b\u00f3l kiemelked\u0151en fontos\nlenne a betegs\u00e9g etiol\u00f3gi\u00e1j\u00e1nak tiszt\u00e1z\u00e1sa.<\/jats:p>","DOI":"10.18071\/isz.77.0397","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T09:55:26Z","timestamp":1733219726000},"page":"397-405","source":"Crossref","is-referenced-by-count":2,"title":["Long COVID \u2013 neurol\u00f3giai vagy szomatiz\u00e1ci\u00f3s betegs\u00e9g?"],"prefix":"10.18071","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8617-8229","authenticated-orcid":false,"given":"Dalma","family":"T\u00e9nyi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"T\u00e9nyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"Janszky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7411","published-online":{"date-parts":[[2024]]},"container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"original-title":[],"link":[{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/long-covid-neurological-or-somatoform-disease\/pdf-open","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T09:55:28Z","timestamp":1733219728000},"score":1,"resource":{"primary":{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/long-covid-neurological-or-somatoform-disease"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":0,"journal-issue":{"issue":"11-12","published-online":{"date-parts":[[2024]]},"published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.18071\/isz.77.0397","relation":{},"ISSN":["0019-1442","2498-6208"],"issn-type":[{"value":"0019-1442","type":"print"},{"value":"2498-6208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}