{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T05:22:03Z","timestamp":1738819323385,"version":"3.37.0"},"reference-count":0,"publisher":"Ideggyogyaszati Szemle Journal","issue":"1-2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background and purpose \u2013 Obstructive\nsleep apnea (OSA) is a common sleep disorder. Despite many studies, its etiology is\nnot clearly known. Polyamines are ubiquitous\npositively charged amines found in all organisms and one of the polyamines types is\nspermidine. In the literature, some articles\ndemonstrate relationship between sleep disorders and polyamines. The common point\nof OSA and polyamines is oxidative stress.\nThis study aimed to determine the serum\nlevels of spermidine in patients with OSA and\ncompare the results with healthy subjects.\nMethods \u2013 This crosssectional casecontrol study was designed with 69 subjects.\nSubjects were selected from people who\nwere referred to polysomnography due to\ncomplaints of sleep disturbance and snoring.\nThey were divided into two groups according\nto their Apnea Hypopnea Index (AHI) scores:\ncontrol (n=29; AHI&lt;5), and OSA (n=40;\nAHI\u22655). Spermidine levels were determined\nin serum samples by using an enzymelinked\nimmunosorbent assay (ELISA) kit.\nResults \u2013 After adjusting for age, body\nmass index (BMI), and gender, there was\nno significant difference in spermidine\nlevels between OSA and controls (p=0.063,\np=0.063, and p=0.818, respectively). There\nwas no correlation between AHI and spermidine levels (rho=\u20130.063; p=0.698). The area\nunder the Receiver Operating Characteristic\n(ROC) curve (AUC) was found to be 0.635 for\nspermidine.\nConclusion \u2013 These results demonstrated\nthat decreased levels of spermidine in OSA patients was related to age, BMI, and gender.\nThe relationship between OSA and the\npolyamines pathway should be the subject\nof future studies with more homogenous\ngroups to understand the roles of polyamines in OSA pathogenesis.<\/jats:p>","DOI":"10.18071\/isz.78.0019","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T13:25:09Z","timestamp":1738761909000},"page":"19-25","source":"Crossref","is-referenced-by-count":0,"title":["A case-control study of spermidine in obstructive sleep apnea"],"prefix":"10.18071","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5768-0720","authenticated-orcid":false,"given":"Edanur","family":"Gurbuz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6416-1442","authenticated-orcid":false,"given":"Ercan","family":"Saruhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4913-976X","authenticated-orcid":false,"given":"Semai","family":"Bek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9325-4151","authenticated-orcid":false,"given":"Gulnihal","family":"Kutlu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7411","published-online":{"date-parts":[[2025]]},"container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"original-title":[],"link":[{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/a-case-control-study-of-spermidine-in-obstructive-sleep-apnea\/pdf-open","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T13:25:12Z","timestamp":1738761912000},"score":1,"resource":{"primary":{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/a-case-control-study-of-spermidine-in-obstructive-sleep-apnea"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2025]]},"published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.18071\/isz.78.0019","relation":{},"ISSN":["0019-1442","2498-6208"],"issn-type":[{"value":"0019-1442","type":"print"},{"value":"2498-6208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}