{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T05:22:03Z","timestamp":1738819323382,"version":"3.37.0"},"reference-count":0,"publisher":"Ideggyogyaszati Szemle Journal","issue":"1-2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background and purpose \u2013 Restless legs\nsyndrome (RLS) is a neurological disorder\ncharacterized by an irresistible urge to move\nthe legs, frequently accompanied by unpleasant sensations. In this study, we aimed to\ndetermine the changes in electrophysiological tests including Fwave responses and\nH-reflex parameters in patients with idiopathic RLS after pramipexole medication.\nMethods \u2013This prospective study was conducted with twenty newly diagnosed, idiopathic RLS patients. The electrophysiological\nparameters, specifically F-wave duration\n(FWD), the duration of related compound\nmuscle action potential (CMAPD), and FWD\/\nCMAPD ratio, the ratio of maximum H-reflex\namplitude(H) to maximum M-response\namplitude (M)(H\/M) were recorded in patients with idiopathic RLS before and after\npramipexole medication.\nResults \u2013 The results revealed significant\nimprovements in specific electrophysiolo\ngical parameters after pramipexole use. We\nobserved a significant decrease in FWD,\nCMAPD, and FWD\/CMAPD values after pramipexole treatment suggesting a reduction\nin motor neuron excitability. We also obser\nved a significant decrease in H\/M ratio after\npramipexole medication indicating reduced\nspinal motor neuron excitability.\nConclusion \u2013 This study demonstrated significant improvement in specific electrophysiological parameters following pramipexole treatment in patients with idiopathic RLS.\nThe findings provide better understanding of\nthe effects of pramipexole on nerve function\nand may contribute to the development of\na monitoring tool and lead to more targeted treatments and interventions for RLS,\nimproving the overall management and care\nfor patients\u2019 outcomes and quality of life with\nthis debilitating condition.<\/jats:p>","DOI":"10.18071\/isz.78.0037","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T13:25:09Z","timestamp":1738761909000},"page":"37-46","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of electrophysiological changes before and after pramipexole treatment in patients diagnosed with idiopathic restless legs syndrome"],"prefix":"10.18071","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0856-9387","authenticated-orcid":false,"given":"Aysel","family":"Tekesin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9277-2870","authenticated-orcid":false,"given":"Nilgun","family":"Erten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0328-9607","authenticated-orcid":false,"given":"Arife","family":"Cimen Atalar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7411","published-online":{"date-parts":[[2025]]},"container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"original-title":[],"link":[{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/evaluation-of-electrophysiological-changes-before-and-after-pramipexole-treatment-in-patients-diagnosed-with-idiopathic-restless-legs-syndrome\/pdf-open","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T13:25:13Z","timestamp":1738761913000},"score":1,"resource":{"primary":{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/evaluation-of-electrophysiological-changes-before-and-after-pramipexole-treatment-in-patients-diagnosed-with-idiopathic-restless-legs-syndrome"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2025]]},"published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.18071\/isz.78.0037","relation":{},"ISSN":["0019-1442","2498-6208"],"issn-type":[{"value":"0019-1442","type":"print"},{"value":"2498-6208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}