{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T16:53:53Z","timestamp":1787331233590,"version":"build-2736575974"},"reference-count":0,"publisher":"Ideggyogyaszati Szemle Journal","issue":"5-6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background and purpose \u2013 The role of\nsynaptic dysfunction in focal epilepsy of\nunknown cause is not well understood.\nNeurogranin is a post-synaptic protein used\nas a biomarker of synaptic disintegration in\npatients with dementia.\nMethods \u2013 To evaluate the association\nbetween synaptic loss, cognitive impairment\nand seizure activity in epilepsy, we collected\nsera of 51 patients with focal epilepsy of\nunknown cause, 26 with frontal lobe epilepsy\n(FLE) and 25 with mesial temporal lobe\nepilepsy with hippocampal sclerosis (MTLEHS), and 25 healthy controls. Serum neurogranin levels were measured by ELISA and\nwe sought for potential correlations between\nneurogranin levels versus clinical features,\ncognitive test and quality of life scores of the\npatients.\nResults \u2013 Neurogranin levels were significantly reduced in MTLE-HS patients as compared\nto FLE patients and healthy controls but were\nnot correlated with any of the clinical and\ncognitive variables. Both FLE and MTLE-HS\npatients with treatment resistance showed\nsignificantly reduced neurogranin levels.\nConclusion \u2013 Our results suggest that\nMTLE-HS patients suffer from reduced synaptic protein production rather than\nincreased synaptic breakdown. Reduction\nof neurogranin is associated with resistance\nto anti-epileptic treatment implying the role\nof this protein in the control of seizures.\nNeurogranin might serve as a biomarker\nfor monitorization of seizure activity in focal\nepilepsies.<\/jats:p>","DOI":"10.18071\/isz.78.0163","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T07:42:11Z","timestamp":1749022931000},"page":"163-168","source":"Crossref","is-referenced-by-count":1,"title":["Treatment-resistant patients with focal epilepsy of unknown cause display reduced neurogranin levels: a preliminary study"],"prefix":"10.18071","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4757-1797","authenticated-orcid":false,"given":"Aysel B\u00fc\u015fra","family":"\u015ei\u015fman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Sava\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizem","family":"Koral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9040-9760","authenticated-orcid":false,"given":"Muhammet Duran","family":"Bayar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O\u011fuz","family":"Yildiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1710-0783","authenticated-orcid":false,"given":"Ayt\u00fcl","family":"Mutlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4809-2966","authenticated-orcid":false,"given":"Vuslat","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4483-0394","authenticated-orcid":false,"given":"Erdem","family":"T\u00fcz\u00fcn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"\u00c7okar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7411","published-online":{"date-parts":[[2025]]},"container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"original-title":[],"link":[{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/treatment-resistant-patients-with-focal-epilepsy-of-unknown-cause-display-reduced-neurogranin-levels-a-preliminary-study\/pdf-open","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T07:42:11Z","timestamp":1749022931000},"score":1,"resource":{"primary":{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/treatment-resistant-patients-with-focal-epilepsy-of-unknown-cause-display-reduced-neurogranin-levels-a-preliminary-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2025]]},"published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.18071\/isz.78.0163","relation":{},"ISSN":["0019-1442","2498-6208"],"issn-type":[{"value":"0019-1442","type":"print"},{"value":"2498-6208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}