{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T17:06:05Z","timestamp":1754154365723,"version":"3.41.2"},"reference-count":0,"publisher":"Ideggyogyaszati Szemle Journal","issue":"7-8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Az eslikarbazepin-acet\u00e1t (ESL) egy n\u00e1triumion\u00adcsatorna-blokkol\u00f3, az els\u0151 vonalbeli antiepileptikumok dibenzazepincsal\u00e1dj\u00e1nak harmadik gener\u00e1ci\u00f3s tagja a karbamazepin (els\u0151 gener\u00e1ci\u00f3) \u00e9s az oxkarbazepin (m\u00e1so\u00addik gener\u00e1ci\u00f3) ut\u00e1n. A karbamazepin tov\u00e1bbfej\u00adleszt\u00e9s\u00e9t els\u0151sorban az a felt\u00e9te\u00adle\u00adz\u00e9s mozd\u00edtotta el\u0151re, hogy a direkt S-li\u00adkar\u00adba\u00adzepin\u00adn\u00e9 metaboliz\u00e1l\u00f3d\u00f3 ESL v\u00e9r-agy g\u00e1ton val\u00f3 \u00e1tjut\u00e1sa nagyobb m\u00e9rt\u00e9k\u0171 lesz az R-enantio\u00admerhez k\u00e9pest, ez\u00e1ltal az el\u0151z\u0151ekn\u00e9l hat\u00e9konyabb \u00e9s kevesebb mell\u00e9khat\u00e1ssal b\u00edr\u00f3\ngy\u00f3gyszert siker\u00fcl el\u0151\u00e1ll\u00edtani. Kontroll\u00e1lt klinikai vizsg\u00e1latok eredm\u00e9nyei alapj\u00e1n meg\u00e1llap\u00edthat\u00f3, hogy a naponta egyszeri adagol\u00e1s\u00fa ESL kieg\u00e9sz\u00edt\u0151 ter\u00e1piak\u00e9nt hat\u00e9kony, j\u00f3l toler\u00e1lhat\u00f3 \u00e9s biztons\u00e1gosan alkalmazhat\u00f3 szekunder generaliz\u00e1ci\u00f3val j\u00e1r\u00f3 vagy a n\u00e9lk\u00fcl fell\u00e9p\u0151 fok\u00e1lis epilepszi\u00e1s rohamok kezel\u00e9s\u00e9re feln\u0151ttekn\u00e9l, serd\u00fcl\u0151kn\u00e9l \u00e9s 6 \u00e9vesn\u00e9l id\u0151sebb gyermekekn\u00e9l. Az ESL monoter\u00e1pi\u00e1ban t\u00f6rt\u00e9n\u0151 alkalmaz\u00e1sa szint\u00e9n szekunder generaliz\u00e1ci\u00f3val j\u00e1r\u00f3 vagy a n\u00e9lk\u00fcl fell\u00e9p\u0151 fok\u00e1lis epilepszi\u00e1s rohamok kezel\u00e9s\u00e9re javasolt \u00fajonnan diagnosztiz\u00e1lt epilepszi\u00e1ban szenved\u0151 feln\u0151ttekn\u00e9l. Az ESL mind monoter\u00e1pi\u00e1ban, mind kombin\u00e1ci\u00f3ban bizony\u00edtottan hat\u00e9kony, j\u00f3l toler\u00e1lhat\u00f3 \u00e9s biztons\u00e1gos antiepileptikum.<\/jats:p>","DOI":"10.18071\/isz.78.0223","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T08:25:05Z","timestamp":1753345505000},"page":"223-227","source":"Crossref","is-referenced-by-count":0,"title":["Az eslikarbazepin-acet\u00e1t helye az epilepszia kezel\u00e9s\u00e9ben feln\u0151ttekben"],"prefix":"10.18071","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6445-8825","authenticated-orcid":false,"given":"D\u00e9lia","family":"Szok","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7411","published-online":{"date-parts":[[2025]]},"container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"original-title":[],"link":[{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/the-place-of-eslicarbazepine-acetate-in-the-treatment-of-epilepsy-in-adults\/pdf-open","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T08:25:05Z","timestamp":1753345505000},"score":1,"resource":{"primary":{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/the-place-of-eslicarbazepine-acetate-in-the-treatment-of-epilepsy-in-adults"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"journal-issue":{"issue":"7-8","published-online":{"date-parts":[[2025]]},"published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.18071\/isz.78.0223","relation":{},"ISSN":["0019-1442","2498-6208"],"issn-type":[{"type":"print","value":"0019-1442"},{"type":"electronic","value":"2498-6208"}],"subject":[],"published":{"date-parts":[[2025]]}}}