{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T16:09:24Z","timestamp":1784563764373,"version":"3.55.0"},"reference-count":0,"publisher":"Ideggyogyaszati Szemle Journal","issue":"7-8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>A direkt or\u00e1lis antikoagul\u00e1nsokkal (DOACkal) kezelt betegek sz\u00e1ma jelent\u0151sen n\u0151. Akut ischaemi\u00e1s stroke-ban a sziszt\u00e9m\u00e1s thrombolysisnek jelenleg ellenjavallata a 48 \u00f3r\u00e1n bel\u00fcl alkalmazott DOAC-kezel\u00e9s, ez\u00e9rt fontos inform\u00e1ci\u00f3 a kezel\u00e9s folyamatoss\u00e1g\u00e1nak, a compliance-nek a k\u00e9rd\u00e9se. Pontos anamn\u00e9zis viszont sok esetben nem nyerhet\u0151. A tromboelasztogr\u00e1f (ClotPro\u00ae) viszkoelasztikus vizsg\u00e1latai seg\u00edts\u00e9g\u00e9vel azonban egy\u00e9rtelm\u0171en kimutathat\u00f3 az antikoagul\u00e1ns hat\u00e1s. Prospekt\u00edv vizsg\u00e1latunk sor\u00e1n 25, akut ischaemi\u00e1s stroke-ot elszenvedett, potenci\u00e1lisan DOAC-ot szed\u0151 beteg eset\u00e9n, amikor autoanamn\u00e9zis nem volt nyerhet\u0151, tromboelasztogr\u00e1f seg\u00edts\u00e9g\u00e9vel Russell Venom Viper- (RVV-) \u00e9s Ecarin assay- (ECA-) tesztet v\u00e9gezt\u00fcnk. Az alvad\u00e1si id\u0151 alapj\u00e1n inform\u00e1ci\u00f3hoz jutottunk az antikoagul\u00e1ns kezel\u00e9s hat\u00e1s\u00e1r\u00f3l, ez\u00e1ltal a compliance-r\u0151l is, ami seg\u00edtett a thrombolysis elb\u00edr\u00e1l\u00e1s\u00e1ban. Tizenegy esetben \u00e9szlelt\u00fck a DOAC-ter\u00e1pia hat\u00e1stalans\u00e1g\u00e1t, melyek k\u00f6z\u00fcl kilenc esetben k\u00e9s\u0151bb heteroanamn\u00e9zis is al\u00e1t\u00e1masztotta a kezel\u00e9s megszak\u00edt\u00e1s\u00e1t. A tesztek seg\u00edts\u00e9g\u00e9vel n\u00e9gy beteg r\u00e9szes\u00fclt thrombolysisben. V\u00e9rz\u00e9ses sz\u00f6v\u0151dm\u00e9nyt egy esetben \u00e9szlelt\u00fcnk, aminek h\u00e1tter\u00e9ben az addig ismeretlen kr\u00f3nikus lymphoid leukaemia miatti fokozott v\u00e9rz\u00e9svesz\u00e9ly \u00e1llt. Az \u00e1ltalunk \u00e9szlelt esetekben a DOACspecifikus viszkoelasztikus tesztek (RVV, ECA) gyors inform\u00e1ci\u00f3t ny\u00fajtottak a 48 \u00f3r\u00e1n bel\u00fcli DOAC-alkalmaz\u00e1sr\u00f3l, \u00edgy kisz\u0171rhet\u0151k azok a betegek, akik a kezel\u00e9st megszak\u00edtott\u00e1k, \u00e9s eset\u00fckben thrombolysis alkalmazhat\u00f3.\n\u00d6sszess\u00e9g\u00e9ben a viszkoelasztikus tesztek gyors seg\u00edts\u00e9get ny\u00fajtanak a klinikusnak a compliance felder\u00edt\u00e9s\u00e9ben \u00e9s a thrombolysis lehet\u0151s\u00e9g\u00e9nek elb\u00edr\u00e1l\u00e1s\u00e1ban.<\/jats:p>","DOI":"10.18071\/isz.78.0283","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T08:25:05Z","timestamp":1753345505000},"page":"283-288","source":"Crossref","is-referenced-by-count":1,"title":["Tromboelasztogr\u00e1f alkalmaz\u00e1sa sziszt\u00e9m\u00e1s thrombolysis el\u0151tt DOAC-kal kezelt betegek eset\u00e9ben : esetsorozat"],"prefix":"10.18071","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5073-9338","authenticated-orcid":false,"given":"L\u00f3r\u00e1nd","family":"Hegyi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5389-3266","authenticated-orcid":false,"given":"P\u00e9ter","family":"Kliv\u00e9nyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2174-011X","authenticated-orcid":false,"given":"Alex","family":"Beke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef Norbert","family":"Nemes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1656-5121","authenticated-orcid":false,"given":"Nikoletta","family":"Szab\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1d\u00e1m","family":"Annus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7411","published-online":{"date-parts":[[2025]]},"container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"original-title":[],"link":[{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/use-of-thromboelastography-prior-to-systemic-thrombolysis-in-patients-treated-with-doacs-case-series\/pdf-open","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T08:25:07Z","timestamp":1753345507000},"score":1,"resource":{"primary":{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/use-of-thromboelastography-prior-to-systemic-thrombolysis-in-patients-treated-with-doacs-case-series"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"journal-issue":{"issue":"7-8","published-online":{"date-parts":[[2025]]},"published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.18071\/isz.78.0283","relation":{},"ISSN":["0019-1442","2498-6208"],"issn-type":[{"value":"0019-1442","type":"print"},{"value":"2498-6208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}