{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:27:41Z","timestamp":1759336061158,"version":"build-2065373602"},"reference-count":0,"publisher":"Ideggyogyaszati Szemle Journal","issue":"9-10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Bevezet\u00e9s\nA gyakran hangulatzavarokkal \u00e9s funkcion\u00e1lis k\u00e1rosod\u00e1ssal t\u00e1rsul\u00f3 kr\u00f3nikus migr\u00e9n (CM) \u00e9s a gy\u00f3gyszert\u00falhaszn\u00e1lat miatti fejf\u00e1j\u00e1s (MOH) jelent\u0151s ter\u00e1pi\u00e1s kih\u00edv\u00e1st jelent. B\u00e1r a profilaktikus gy\u00f3gyszeres ter\u00e1pia tov\u00e1bbra is alapvet\u0151 fontoss\u00e1g\u00fa, kieg\u00e9sz\u00edt\u0151 beavatkoz\u00e1sok \u2013 mint a nervus occipitalis major (GON) \u00e9s a supraorbitalis ideg (SON) blok\u00e1dja \u2013 tov\u00e1bbi el\u0151nyt k\u00edn\u00e1lhatnak. A jelen vizsg\u00e1lat c\u00e9lja annak felm\u00e9r\u00e9se volt, hogy e blok\u00e1dok standard gy\u00f3gyszeres profilaxis melletti alkalmaz\u00e1sa jav\u00edtja-e a hangulatot \u00e9s a funkcion\u00e1lis \u00e1llapotot CM-ben vagy MOHban szenved\u0151 betegekn\u00e9l.\n\nM\u00f3dszerek\nRetrospekt\u00edv elemz\u00e9st v\u00e9gez- t\u00fcnk 147 olyan beteg (131 n\u0151, 16 f\u00e9rfi) adata alapj\u00e1n, akiket 2020. december \u00e9s 2021. m\u00e1rcius k\u00f6z\u00f6tt kezeltek. A betegeket h\u00e1rom csoportba osztottuk: kiz\u00e1r\u00f3lag profilaktikus gy\u00f3gyszeres kezel\u00e9sben r\u00e9szes\u00fcltek; profilaktikus kezel\u00e9s GON-blok\u00e1ddal kieg\u00e9sz\u00edtve; valamint profilaktikus kezel\u00e9s kombi- n\u00e1lt GON + SON blok\u00e1ddal. A f\u00e1jdalom- \u00e9s funkcion\u00e1lis mutat\u00f3kat a vizu\u00e1lis anal\u00f3g sk\u00e1la (VAS), a Migraine Disability Assessment Scale (MIDAS) \u00e9s a Beck Depresszi\u00f3 K\u00e9rd\u0151\u00edv (BDI) seg\u00edts\u00e9g\u00e9vel \u00e9rt\u00e9kelt\u00fck. A statisztikai elemz\u00e9shez a Statistical Package for the Social Sciences (SPSS) \u00e9s az R szoftvert haszn\u00e1ltuk nem param\u00e9teres longitudin\u00e1lis adatok feldolgoz\u00e1s\u00e1ra.\n\nEredm\u00e9nyek\nA GON + SON blok\u00e1d szigni- fik\u00e1nsan cs\u00f6kkentette a VAS-\u00e9rt\u00e9keket m\u00e1r a 2. h\u00e9tt\u0151l kezdve (Mann\u2013Whitney U-teszt p = 0,021), gyorsabb javul\u00e1st mutatva a t\u00f6bbi csoporthoz k\u00e9pest. A MIDAS-pontsz\u00e1mok minden csoportban szignifik\u00e1nsan javultak, a cs\u00f6kken\u00e9s a kombin\u00e1lt GON + SON blok\u00e1d eset\u00e9ben volt a legnagyobb (Wald- id\u0151 statisztika [WTS] = 1262,52; p &lt; 0,01). A BDI-pontsz\u00e1mok szignifik\u00e1nsan javultak az id\u0151 el\u0151rehaladt\u00e1val (WTS = 997,89; p &lt; 0,01), azonban kezel\u00e9sspecifikus el\u0151ny nem volt kimutathat\u00f3. Csak minim\u00e1lis, j\u00f3l kezelhet\u0151, enyhe sz\u00f6v\u0151dm\u00e9nyek fordultak el\u0151, ami meger\u0151s\u00edtette az elj\u00e1r\u00e1s biztons\u00e1goss\u00e1g\u00e1t.\n\nK\u00f6vetkeztet\u00e9s\nA GON- \u00e9s SON-blok\u00e1d hozz\u00e1ad\u00e1sa a profilaktikus gy\u00f3gyszeres kezel\u00e9shez fokozza a f\u00e1jdalomcs\u00f6kken\u00e9st \u00e9s a funkcion\u00e1lis javul\u00e1st CM- \u00e9s MOH-betegekben. A kombin\u00e1lt blok\u00e1d gyorsabb \u00e9s szignifik\u00e1ns el\u0151nnyel j\u00e1r, a VAS-\u00e9rt\u00e9kek m\u00e1r a m\u00e1sodik h\u00e9tt\u0151l javulnak. A BDI-pontsz\u00e1mok minden csoportban javultak, azonban a hangulatra gyakorolt pozit\u00edv hat\u00e1s pontosabb meg\u00edt\u00e9l\u00e9s\u00e9hez tov\u00e1bbi vizsg\u00e1latok sz\u00fcks\u00e9gesek. A j\u00f6v\u0151ben multicentrikus, randomiz\u00e1lt kontroll\u00e1lt vizsg\u00e1latok sz\u00fcks\u00e9gesek.<\/jats:p>","DOI":"10.18071\/isz.78.0339","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T08:58:06Z","timestamp":1759309086000},"page":"339-347","source":"Crossref","is-referenced-by-count":0,"title":["Az idegblok\u00e1d hat\u00e1sa a hangulatra \u00e9s a funkcion\u00e1lis aktivit\u00e1sra kr\u00f3nikus migr\u00e9nben \u00e9s gy\u00f3gyszert\u00falhaszn\u00e1lat miatti fejf\u00e1j\u00e1sban szenved\u0151 betegek k\u00f6r\u00e9ben"],"prefix":"10.18071","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6870-2282","authenticated-orcid":false,"given":"Ahmet","family":"Basari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9804-9207","authenticated-orcid":false,"given":"G\u00f6khan","family":"Pek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4800-3150","authenticated-orcid":false,"given":"Ibrahim","family":"Asik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7411","published-online":{"date-parts":[[2025]]},"container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"original-title":[],"link":[{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/do-nerve-blocks-boost-mood-and-functional-activity-in-patients-with-chronic-migraine-and-medication-overuse-headache\/pdf-open","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T08:58:07Z","timestamp":1759309087000},"score":1,"resource":{"primary":{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/do-nerve-blocks-boost-mood-and-functional-activity-in-patients-with-chronic-migraine-and-medication-overuse-headache"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"journal-issue":{"issue":"9-10","published-online":{"date-parts":[[2025]]},"published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.18071\/isz.78.0339","relation":{},"ISSN":["0019-1442","2498-6208"],"issn-type":[{"value":"0019-1442","type":"print"},{"value":"2498-6208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}