{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T09:44:41Z","timestamp":1764582281401,"version":"3.46.0"},"reference-count":0,"publisher":"Ideggyogyaszati Szemle Journal","issue":"11-12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background and purpose \u2013 Misfolded\nprotein stress has come to the fore among\nthe molecular mechanisms that can cause\ndegeneration. Whereas one of the most\nimportant protein of adaptive Endoplasmic\nReticulum stress (ERS) is XBP1, CHOP and\nASK proteins are associated with apoptosis\nand terminal ERS. To the best of our knowledge, methylation levels of adaptive and\nterminal ERS genes in Parkinson\u2019s Disease\n(PD) patients\u2019 blood are unknown. We aimed\nto evaluate if there is a difference in the\nDNA methylation levels of the ERS related\nprotein-coding genes in peripheral blood of\nPD patients compared with healthy controls.\nThe clinical significance of these gene methylation levels was evaluated as the second\naim.\nMethods \u2013 DNA was isolated from the\nblood of PD patients (n=23) and controls\n(n=19). We used a methylation-specific qPCR\napproach to assess the methylation status\nof the ERS genes. The correlation between\nclinical findings and the methylation levels in\nPD patients were evaluated with appropriate\nstatistical methods.\nResults \u2013 Terminal ERS related genes were\nstatistically significantly hypomethylated\nin PD (ASK1 p=0.020, and CHOP p&lt;0.001)\nwhereas adaptive ERS gene XBP1\u2019s methylation level was not different between groups.\nExcept for XBP1 and MMSE positive, and\nCHOP and depression negative correlation\nno correlation was found between clinical markers and methylation levels of the selected genes. (p=0.040, p=0.024),\nConclusion \u2013 PD patients\u2019 peripheral blood\nmethylation levels of adaptive and terminal\nERS related genes are significantly different\nfrom healthy controls\u2019. While XBP1 is known\nto be neuroprotective, CHOP and ASK are\nimportant proteins in apoptosis, and their\nmethylation differences in peripheral blood\nprovide a clue that they could be used as\nbiomarkers in the future. Therefore, further\nbiomarker and treatment studies should\nbe conducted on these proteins and their\npathways.<\/jats:p>","DOI":"10.18071\/isz.78.0417","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T09:39:56Z","timestamp":1764581996000},"page":"417-423","source":"Crossref","is-referenced-by-count":0,"title":["Adaptive and terminal endoplasmic reticulum stress genes methylation levels in Parkinson patients\u2019 peripheral blood"],"prefix":"10.18071","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7888-5396","authenticated-orcid":false,"given":"Yagmur \u0130nalkac","family":"Gemici","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6509-2012","authenticated-orcid":false,"given":"Muhammed","family":"Dundar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1208-4072","authenticated-orcid":false,"given":"Harika Gozde","family":"Gozukara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3484-2137","authenticated-orcid":false,"given":"Ahmet","family":"Koc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7411","published-online":{"date-parts":[[2025]]},"container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"original-title":[],"link":[{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/adaptive-and-terminal-endoplasmic-reticulum-stress-genes-methylation-levels-in-parkinson-patients-peripheral-blood\/pdf-open","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T09:39:57Z","timestamp":1764581997000},"score":1,"resource":{"primary":{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/adaptive-and-terminal-endoplasmic-reticulum-stress-genes-methylation-levels-in-parkinson-patients-peripheral-blood"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"journal-issue":{"issue":"11-12","published-online":{"date-parts":[[2025]]},"published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.18071\/isz.78.0417","relation":{},"ISSN":["0019-1442","2498-6208"],"issn-type":[{"value":"0019-1442","type":"print"},{"value":"2498-6208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}