{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T14:53:05Z","timestamp":1774536785641,"version":"3.50.1"},"reference-count":0,"publisher":"Ideggyogyaszati Szemle Journal","issue":"3-4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Bevezet\u00e9s\nA sclerosis multiplex (SM) diagnosztikai krit\u00e9riumai t\u00f6bbsz\u00f6r v\u00e1ltoztak az elm\u00falt \u00e9vtizedekben, t\u00f6rekedve a betegs\u00e9g min\u00e9l kor\u00e1bbi felismer\u00e9s\u00e9re, ugyanakkor cs\u00f6kkentve a t\u00e9ves diagn\u00f3zisok kock\u00e1zat\u00e1t. Mivel a legut\u00f3bbi, 2017-es krit\u00e9riumrendszer bevezet\u00e9se \u00f3ta t\u00f6bb ter\u00fcleten is jelent\u0151s el\u0151rel\u00e9p\u00e9sek t\u00f6rt\u00e9ntek, felmer\u00fclt tov\u00e1bbi v\u00e1ltoztat\u00e1sok ig\u00e9nye.\n\nM\u00f3dszerek\n2024-ben mutatt\u00e1k be a konszenzusos aj\u00e1nl\u00e1sokon kereszt\u00fcl \u00f6ssze\u00e1ll\u00edtott \u00faj javaslatot, amelyet 2025 okt\u00f3ber\u00e9ben publik\u00e1ltak. K\u00fcl\u00f6n k\u00e9ziratokat szenteltek a legfontosabb paraklinikai vizsg\u00e1lati m\u00f3d\u00adsze\u00adrek szerep\u00e9nek bemutat\u00e1s\u00e1ra. A k\u00f6\u00advetkez\u0151kben \u00f6sszefoglaljuk a legfontosabb \u00faj\u00ad dons\u00e1gokat a 2024-es McDonald-kri\u00adt\u00e9\u00adrium\u00ad rendszerre vonatkoz\u00f3an.\n\nEredm\u00e9nyek\nAz \u00f6ssze\u00e1ll\u00edt\u00e1s sor\u00e1n k\u00e9t \u00e1l\u00ad tal\u00e1nos szemponthoz ragaszkodtak: a krit\u00e9riumok vil\u00e1gszerte alkalmazhat\u00f3k legyenek, \u00e9s a diagnosztik\u00e1ban alapvet\u0151 szerepet kapjanak a paraklinikai vizsg\u00e1latok. A jellegzetes MRI-laesi\u00f3k detekt\u00e1l\u00e1sa tov\u00e1bbra is a diagn\u00f3zis alapj\u00e1nak tekinthet\u0151. A l\u00e1t\u00f3ideg \u00f6t\u00f6dik r\u00e9gi\u00f3k\u00e9nt val\u00f3 bevon\u00e1sa, valamint a centr\u00e1lis v\u00e9najel \u00e9s a param\u00e1gneses peremlaesio detekt\u00e1l\u00e1sa cs\u00f6kkenti a t\u00e9ves diagn\u00f3zisok kock\u00e1zat\u00e1t, m\u00edg a kappa k\u00f6nny\u0171 l\u00e1nc index az oligoklon\u00e1lis gammopathia helyettes\u00edt\u00e9sre haszn\u00e1lhat\u00f3 a diagn\u00f3zis fel\u00e1ll\u00edt\u00e1sa sor\u00e1n. Egys\u00e9ges biol\u00f3giai keretrendszer kialak\u00edt\u00e1s\u00e1val a k\u00fcl\u00f6nb\u00f6z\u0151 k\u00f3rlefoly\u00e1ssal j\u00e1r\u00f3 form\u00e1k, megfelel\u0151 felt\u00e9telek fenn\u00e1ll\u00e1sa eset\u00e9n pedig az at\u00edpusos t\u00fcnetekkel rendelkez\u0151, vagy t\u00fcnetmentes, radiol\u00f3giailag izol\u00e1lt szindr\u00f3m\u00e1ba sorolt betegek is sclerosis multiplex diagn\u00f3zist kaphatnak. Els\u0151sorban a differenci\u00e1ldiagnosztik\u00e1ban jelentenek seg\u00edts\u00e9get az id\u0151skori indul\u00e1s\u00fa SM-mel \u00e9s t\u00e1rsbetegs\u00e9ggel \u00e9l\u0151kre vonatkoz\u00f3 aj\u00e1nl\u00e1sok.\n\nK\u00f6vetkeztet\u00e9s\nA diagnosztikus krit\u00e9riumok id\u0151szakos friss\u00edt\u00e9se, egys\u00e9ges\u00edt\u00e9se \u00e9s a biomarkerek alkalmaz\u00e1sa k\u00f6nnyebb\u00e9 teheti a diagn\u00f3zis fel\u00e1ll\u00edt\u00e1s\u00e1t, lehet\u0151s\u00e9get ad a te r\u00e1\u00ad pia miel\u0151bbi ind\u00edt\u00e1s\u00e1ra, befoly\u00e1solva az SM-mel \u00e9l\u0151 betegek k\u00e9s\u0151bbi \u00e9letmin\u0151s\u00e9g\u00e9t.<\/jats:p>","DOI":"10.18071\/isz.79.0121","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:58:41Z","timestamp":1774533521000},"page":"121-128","source":"Crossref","is-referenced-by-count":0,"title":["\u00dajdons\u00e1gok a sclerosis multiplex diagn\u00f3zis\u00e1ban: a 2024-es McDonald-krit\u00e9riumok \u00e1ttekint\u00e9se"],"prefix":"10.18071","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3797-2191","authenticated-orcid":false,"given":"Zsolt","family":"Mezei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7411","published-online":{"date-parts":[[2026]]},"container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"original-title":[],"link":[{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/new-developments-in-the-diagnosis-of-multiple-sclerosis-review-of-the-2024-mcdonalds-criteria\/pdf-open","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:58:42Z","timestamp":1774533522000},"score":1,"resource":{"primary":{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/new-developments-in-the-diagnosis-of-multiple-sclerosis-review-of-the-2024-mcdonalds-criteria"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2026]]},"published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.18071\/isz.79.0121","relation":{},"ISSN":["0019-1442","2498-6208"],"issn-type":[{"value":"0019-1442","type":"print"},{"value":"2498-6208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}