{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:05:20Z","timestamp":1780387520300,"version":"3.54.1"},"reference-count":0,"publisher":"Ideggyogyaszati Szemle Journal","issue":"5-6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background and purpose \u2013 Acute ischemic\nstroke (AIS) is often encountered during\nthe clinical course of coronavirus disease\n2019 (COVID-19) infection. Accumulated\nevidence has indicated involvement of\nferroptosis in AIS. Our aim was to investigate\nthe association between serum levels of\nferroptosis markers and severity of AIS in\nCOVID-19 patients.\nMethods \u2013 Twenty-nine consecutively\nenrolled COVID-19+ pneumonia patients\nwith AIS due to middle cerebral artery\n(MCA) occlusion, 25 COVID-19+ pneumonia\npatients without AIS and 26 AIS patients\nwithout COVID-19 infection were included.\nSerum levels of ferroptosis markers\nglutathione peroxidase 4 (GPX4), dipeptidylpeptidase-4 (DPP4) and soluble transferrin\nreceptor 1 (sTFR1) were measured by ELISA.\nResults \u2013 While serum GPX4 levels were\ncomparable among groups, COVID-19\npatients with and without AIS showed\nsignificantly increased serum sTFR1 levels\nand COVID-19 patients with AIS showed\nsignificantly decreased serum DPP4 levels.\nIn patients with COVID-19 and AIS, serum\nlevels of DPP4 and sTFR1 respectively\nshowed negative and positive correlation\nwith levels of D-dimer and\/or C-reactive\nprotein (CRP). Levels of ferroptosis markers\ndid not correlate with clinical\/prognostic\nfeatures of pneumonia or AIS. Nevertheless, COVID-19 patients with higher (\u2265 131 pg\/\nml) sTFR1 levels were more likely to exhibit\nsevere pneumonia, increased clinical severity\nof AIS (assessed by the national institutes of\nhealth stroke and modified Rankin scales)\nand elevated D-dimer\/CRP levels. Our results\nindicate TFR1 as a potential role player in\nboth COVID-19 pneumonia and arterial\nthrombosis associated with COVID-19\ninfection. The biomarker utility of sTFR1 in\nthese disorders should further be evaluated.\nConclusion \u2013 Our results suggest that AIS\nassociated with COVID-19 have a different\npathogenesis.<\/jats:p>","DOI":"10.18071\/isz.79.0181","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:07:21Z","timestamp":1780384041000},"page":"181-188","source":"Crossref","is-referenced-by-count":0,"title":["Increased serum transferrin receptor 1 levels are associated with severity of acute ischemic stroke in patients with Covid-19 pneumonia"],"prefix":"10.18071","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5985-900X","authenticated-orcid":false,"given":"Z\u00fclfikar","family":"Memi\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4353-5684","authenticated-orcid":false,"given":"Selen","family":"Soylu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9040-9760","authenticated-orcid":false,"given":"Muhammet Duran","family":"Bayar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4757-1797","authenticated-orcid":false,"given":"Aysel B\u00fc\u015fra","family":"\u015ei\u015fman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1835-2608","authenticated-orcid":false,"given":"Nuray","family":"Sancar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4483-0394","authenticated-orcid":false,"given":"Erdem","family":"T\u00fcz\u00fcn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8285-4901","authenticated-orcid":false,"given":"Birg\u00fcl","family":"Ba\u015ftan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7411","published-online":{"date-parts":[[2026]]},"container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"original-title":[],"link":[{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/increased-serum-transferrin-receptor-1-levels-are-associated-with-severity-of-acute-ischemic-stroke-in-patients-with-covid-19-pneumonia\/pdf-open","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:07:27Z","timestamp":1780384047000},"score":1,"resource":{"primary":{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/increased-serum-transferrin-receptor-1-levels-are-associated-with-severity-of-acute-ischemic-stroke-in-patients-with-covid-19-pneumonia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2026]]},"published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.18071\/isz.79.0181","relation":{},"ISSN":["0019-1442","2498-6208"],"issn-type":[{"value":"0019-1442","type":"print"},{"value":"2498-6208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}