{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:04:51Z","timestamp":1780387491282,"version":"3.54.1"},"reference-count":0,"publisher":"Ideggyogyaszati Szemle Journal","issue":"5-6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Bevezet\u00e9s \u2013 A migr\u00e9n gyakori, els\u0151sorban\nn\u0151ket \u00e9rint\u0151 neurol\u00f3giai betegs\u00e9g, amely\njelent\u0151sen rontja az \u00e9letmin\u0151s\u00e9get. A CGRPrendszert c\u00e9lz\u00f3 monoklon\u00e1lis antitestek\nmegjelen\u00e9se jelent\u0151s el\u0151rel\u00e9p\u00e9st hozott a\nmegel\u0151z\u0151 kezel\u00e9sben. Vizsg\u00e1latunk c\u00e9lja az\nerenumab \u00e9s fremanezumab val\u00f3 \u00e9letben\ntapasztalt hat\u00e9konys\u00e1g\u00e1nak \u00e9rt\u00e9kel\u00e9se volt\nmagyarorsz\u00e1gi betegek k\u00f6r\u00e9ben.\nM\u00f3dszerek \u2013 Retrospekt\u00edv, multicentrikus\nvizsg\u00e1latunkban 12 hazai fejf\u00e1j\u00e1scentrum\nadatait elemezt\u00fck 2024 m\u00e1jusa \u00e9s decembere k\u00f6z\u00f6tt. \u00d6sszesen 200, erenumab- vagy\nfremanezumabkezel\u00e9sben r\u00e9szes\u00fcl\u0151 beteg\nadatait dolgoztuk fel. A migr\u00e9n t\u00edpus\u00e1t, a betegek nem\u00e9t \u00e9s a kezel\u00e9s jellemz\u0151it\nr\u00f6gz\u00edtett\u00fck. A havi migr\u00e9nes napok sz\u00e1m\u00e1t\n\u00e9s a tript\u00e1nhaszn\u00e1latot hasonl\u00edtottuk \u00f6ssze a\nkezel\u00e9s el\u0151tti 3 h\u00f3nap \u00e9s a kezel\u00e9s 3. h\u00f3napja k\u00f6z\u00f6tt. A statisztikai elemz\u00e9s sor\u00e1n p\u00e1ros\nt-pr\u00f3b\u00e1t, Wilcoxon-pr\u00f3b\u00e1t \u00e9s sz\u00fcks\u00e9g eset\u00e9n\npermut\u00e1ci\u00f3s tesztet alkalmaztunk.\nEredm\u00e9nyek \u2013 Mindk\u00e9t kezel\u00e9s eset\u00e9n szignifik\u00e1ns cs\u00f6kken\u00e9st tal\u00e1ltunk a havi migr\u00e9nes\nnapok sz\u00e1m\u00e1ban \u00e9s a tript\u00e1nhaszn\u00e1latban,\nepizodikus \u00e9s kr\u00f3nikus migr\u00e9nben egyar\u00e1nt\n(minden esetben p &lt; 0,001). Fremanezumabkezel\u00e9s mellett az epizodikus migr\u00e9nes\nbetegekben a medi\u00e1n migr\u00e9nes napok sz\u00e1ma\n10,0-r\u0151l 2,0-re, kr\u00f3nikus migr\u00e9nben 17,5-r\u0151l\n6,0-ra cs\u00f6kkent. Erenumab eset\u00e9n az \u00e1tlagos\nhavi migr\u00e9nes napok sz\u00e1ma epizodikus migr\u00e9nben 10,8-r\u00f3l 4,3-ra, kr\u00f3nikus migr\u00e9nben\n18,6-r\u00f3l 8,9-re cs\u00f6kkent. A tript\u00e1nhaszn\u00e1lat\nmindk\u00e9t csoportban szignifik\u00e1nsan m\u00e9rs\u00e9kl\u0151d\u00f6tt. Nem reag\u00e1l\u00f3 betegek kis sz\u00e1mban fordultak el\u0151. A hat\u00e9konys\u00e1g mindk\u00e9t nemben\nigazolhat\u00f3 volt, azonban a f\u00e9rfialcsoportok kis\nelemsz\u00e1ma korl\u00e1tozza az \u00e9rt\u00e9kel\u00e9st.\nK\u00f6vetkeztet\u00e9s \u2013 A magyarorsz\u00e1gi val\u00f3\u00e9letadatok alapj\u00e1n az erenumab \u00e9s a fremanezumab hat\u00e9konyan cs\u00f6kkenti a migr\u00e9nes\nnapok sz\u00e1m\u00e1t \u00e9s az akut gy\u00f3gyszerhaszn\u00e1latot m\u00e1r a kezel\u00e9s els\u0151 h\u00e1rom h\u00f3napj\u00e1ban.\nEredm\u00e9nyeink al\u00e1t\u00e1masztj\u00e1k a CGRP-c\u00e9lzott\nmonoklon\u00e1lis antitestek alkalmaz\u00e1s\u00e1t a\nmigr\u00e9n megel\u0151z\u0151 kezel\u00e9s\u00e9ben, ugyanakkor\ntov\u00e1bbi vizsg\u00e1latok sz\u00fcks\u00e9gesek a nemek k\u00f6z\u00f6tti k\u00fcl\u00f6nbs\u00e9gek pontosabb meg\u00edt\u00e9l\u00e9s\u00e9re.<\/jats:p>","DOI":"10.18071\/isz.79.0189","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:07:21Z","timestamp":1780384041000},"page":"189-196","source":"Crossref","is-referenced-by-count":0,"title":["Fremanezumab \u00e9s erenumab a migr\u00e9n profilaxis\u00e1ban \u2013 magyarorsz\u00e1gi val\u00f3 \u00e9letbeli 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