{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:57:53Z","timestamp":1785855473597,"version":"3.56.0"},"reference-count":0,"publisher":"Ideggyogyaszati Szemle Journal","issue":"7-8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Bevezet\u00e9s\nA migr\u00e9n profilaxis\u00e1ban specifikus ter\u00e1pi\u00e1s lehet\u0151s\u00e9get ny\u00fajtanak a kalcitonin g\u00e9nnel rokon peptidet (CGRP) \u00e9s receptor\u00e1t c\u00e9lz\u00f3 monoklon\u00e1lis ellenanya- gok (mAb), a CGRP-receptor-antagonist\u00e1k (gep\u00e1ntok), valamint az 5-hidroxitriptamin 1F receptor-agonista dit\u00e1nok. \u00daj t\u00e1mad\u00e1s- pontot k\u00e9pviselnek a hypophysis adenil\u00e1t- cikl\u00e1zaktiv\u00e1l\u00f3 polipeptidre (PACAP) vagy receptor\u00e1ra (PAC1) hat\u00f3 mAb-ok\n\nM\u00f3dszerek\nIrodalmi \u00f6sszefoglal\u00e1s PubMed-keres\u00e9s alapj\u00e1n.\n\nEredm\u00e9nyek\nPAC1 receptor elleni hum\u00e1n mAb-bal (subcutan AMG 301) v\u00e9gzett 2a f\u00e1zis\u00fa randomiz\u00e1lt klinikai vizsg\u00e1lat eredm\u00e9nyei azt mutatt\u00e1k, hogy nem volt k\u00fcl\u00f6nbs\u00e9g a placebo \u00e9s az akt\u00edv farmakon k\u00f6z\u00f6tt a havonk\u00e9nti migr\u00e9nes napok sz\u00e1m\u00e1nak cs\u00f6kken\u00e9s\u00e9ben. A HOPE tanulm\u00e1ny (2-es f\u00e1zis\u00fa) a PACAP-ot mint ligandot c\u00e9lozta humaniz\u00e1lt mAb, intrav\u00e9n\u00e1s Lu AG09222 alacsony (100 mg) \u00e9s magas (750 mg) d\u00f3zisban t\u00f6rt\u00e9nt ad\u00e1s\u00e1val epizodikus \u00e9s kr\u00f3nikus migr\u00e9nesekben. A havonk\u00e9nti migr\u00e9nes napok sz\u00e1m\u00e1nak cs\u00f6kken\u00e9se az alap\u00e9rt\u00e9khez k\u00e9pest 4 h\u00e9t kezel\u00e9st k\u00f6vet\u0151en a magasabb d\u00f3zis\u00fa akt\u00edv csoportban \u20136,2 nap, m\u00edg a placebocsoportban \u20134,2 nap volt. Egy nemr\u00e9giben megjelent 2-es f\u00e1zis\u00fa klinikai vizsg\u00e1lat, mely a PACAP-ot c\u00e9lz\u00f3 hum\u00e1n mAb-ot (egy alkalommal 1500 mg intrav\u00e9n\u00e1s LY3451838) vizsg\u00e1lta, nem mutatott k\u00fcl\u00f6nbs\u00e9get a havonk\u00e9nti migr\u00e9nes napok sz\u00e1m\u00e1nak cs\u00f6kken\u00e9s\u00e9ben epizodikus \u00e9s kr\u00f3nikus migr\u00e9nes betegekben. V\u00e1rhat\u00f3an hamarosan publik\u00e1l\u00e1sra ker\u00fcl a PROCEED vizsg\u00e1lat kimenetele, mely n\u00e9gy k\u00fcl\u00f6nb\u00f6z\u0151 d\u00f3zis\u00fa Lu AG09222 hat\u00e9konys\u00e1g\u00e1t \u00e9rt\u00e9keli migr\u00e9nprevenci\u00f3ban.\n\nK\u00f6vetkeztet\u00e9s\nA korai f\u00e1zis\u00fa PACAP \u00e9s receptora elleni mAb-okkal t\u00f6rt\u00e9nt kezel\u00e9s megfigyel\u00e9s\u00e9nek eredm\u00e9nyeib\u0151l levonhat\u00f3 k\u00f6vetkeztet\u00e9sek alapj\u00e1n tov\u00e1bbi nagyobb f\u00e1zis\u00fa klinikai tanulm\u00e1nyok elv\u00e9gz\u00e9se sz\u00fcks\u00e9ges.<\/jats:p>","DOI":"10.18071\/isz.79.0223","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:39:51Z","timestamp":1785854391000},"page":"223-229","source":"Crossref","is-referenced-by-count":0,"title":["Hypophysis adenil\u00e1t-cikl\u00e1z aktiv\u00e1l\u00f3 polipeptid (PACAP) t\u00e1mad\u00e1spont\u00fa ter\u00e1pia mint a migr\u00e9n lehets\u00e9ges megel\u0151z\u0151 kezel\u00e9se"],"prefix":"10.18071","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-3176","authenticated-orcid":false,"given":"J\u00e1nos","family":"Tajti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anett","family":"Cs\u00e1ti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"K\u00f6rt\u00e9si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"V\u00e9csei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9lia","family":"Szok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7411","published-online":{"date-parts":[[2026]]},"container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"original-title":[],"link":[{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/pituitary-adenylate-cyclase-activating-polypeptide-pacap-targeting-treatment-as-a-potential-migraine-prophylactic-therapy\/pdf-open","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:39:51Z","timestamp":1785854391000},"score":1,"resource":{"primary":{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/pituitary-adenylate-cyclase-activating-polypeptide-pacap-targeting-treatment-as-a-potential-migraine-prophylactic-therapy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"7-8","published-online":{"date-parts":[[2026]]},"published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.18071\/isz.79.0223","relation":{},"ISSN":["0019-1442","2498-6208"],"issn-type":[{"value":"0019-1442","type":"print"},{"value":"2498-6208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}