{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:11:31Z","timestamp":1790079091986,"version":"4.0.1"},"reference-count":0,"publisher":"Ideggyogyaszati Szemle Journal","issue":"9-10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Bevezet\u00e9s\nA szagl\u00e1szavar a Parkinson-k\u00f3r (PK) j\u00f3l ismert prodromalis t\u00fcnete. A szagl\u00e1sveszt\u00e9s \u00e9s az \u00edz\u00e9rz\u00e9kel\u00e9s megv\u00e1ltoz\u00e1s\u00e1nak \u2013 k\u00fcl\u00f6n\u00f6sen az umami \u00edz percepci\u00f3ja megv\u00e1ltoz\u00e1s\u00e1nak \u2013 \u00f6sszef\u00fcgg\u00e9se, valamint ezek kapcsolata a nem motoros t\u00fcnetekkel (NMS), az affekt\u00edv \u00e1llapottal, a jutalmaz\u00e1svez\u00e9relt ev\u00e9si magatart\u00e1ssal \u00e9s az \u00e9letmin\u0151s\u00e9ggel (QoL) azonban tov\u00e1bbra sem teljesen tiszt\u00e1zott. A vizsg\u00e1lat c\u00e9lja az objekt\u00edven meghat\u00e1rozott anosmia, valamint az \u00edz\u00e9rz\u00e9kel\u00e9s, az NMS, a hangulatzavarok, a jutalmaz\u00e1svez\u00e9relt ev\u00e9si magatart\u00e1s \u00e9s a QoL k\u00f6z\u00f6tti \u00f6sszef\u00fcgg\u00e9sek vizsg\u00e1lata volt Parkinson-k\u00f3rban szenved\u0151 betegek k\u00f6r\u00e9ben.\n\nM\u00f3dszerek\nA keresztmetszeti vizsg\u00e1latban 150, idiopathi\u00e1s PD-ben szenved\u0151 beteg vett r\u00e9szt. A szagl\u00e1sfunkci\u00f3t a Brief Smell Identification Test (BSIT) seg\u00edts\u00e9g\u00e9vel \u00e9rt\u00e9kelt\u00e9k. A saj\u00e1t besz\u00e1mol\u00f3juk szerint teljesen szagl\u00e1svesztett, valamint a \u22648 BSIT-pontsz\u00e1mot el\u00e9r\u0151 betegeket anosmi\u00e1snak min\u0151s\u00edtett\u00e9k (n = 75), m\u00edg a fennmarad\u00f3 betegeket nem anosmi\u00e1s csoportba sorolt\u00e1k (n = 75). Az \u00f6t alap\u00edz (\u00e9des, savany\u00fa, s\u00f3s, keser\u0171 \u00e9s umami) \u00e9rz\u00e9kel\u00e9s\u00e9t vizu\u00e1lis anal\u00f3g sk\u00e1l\u00e1kkal (VAS) \u00e9rt\u00e9kelt\u00e9k. A jutalmaz\u00e1svez\u00e9relt ev\u00e9si magatart\u00e1st a Palatable Eating Motives Scale (PEMS), a Food Cravings Questionnaire\u2013Trait (FCQ-T) \u00e9s a Power of Food Scale (PFS) seg\u00edts\u00e9g\u00e9vel vizsg\u00e1lt\u00e1k. A nem motoros t\u00fcnetek terh\u00e9t a szagl\u00e1sra korrig\u00e1lt Non-Motor Symptoms Scale (NMSS Total*) seg\u00edts\u00e9g\u00e9vel \u00e9rt\u00e9kelt\u00e9k. A hangulatot, a szorong\u00e1st \u00e9s az \u00e9letmin\u0151s\u00e9get a Beck Depression Inventory (BDI), a Beck Anxiety Inventory (BAI), illetve a Parkinson\u2019s Disease Questionnaire\u201339 (PDQ-39) alkalmaz\u00e1s\u00e1val vizsg\u00e1lt\u00e1k.\n\nEredm\u00e9nyek\nAz anosmi\u00e1s betegek umami\u00edz-\u00e9rz\u00e9kel\u00e9s\u00e9nek VAS-pontsz\u00e1ma szignifik\u00e1nsan alacsonyabb volt, mint a nem anosmi\u00e1s betegek\u00e9 (p = 0,018), m\u00edg a t\u00f6bbi alap\u00edz \u00e9rz\u00e9kel\u00e9s\u00e9ben nem mutatkozott szignifik\u00e1ns k\u00fcl\u00f6nbs\u00e9g a csoportok k\u00f6z\u00f6tt. Az NMSS Total* pontsz\u00e1mok numerikusan magasabbak voltak az anosmi\u00e1s csoport-ban, aminek tagjai szignifik\u00e1nsan nagyobb k\u00e1rosod\u00e1st mutattak a hangulat\/ap\u00e1tia, va-lamint a szexu\u00e1lis t\u00fcnetek dom\u00e9njeiben is. A depressz\u00edv t\u00fcnetek s\u00falyoss\u00e1ga szignifik\u00e1nsan nagyobb volt az anosmi\u00e1s betegek k\u00f6r\u00e9ben (p = 0,023). B\u00e1r a teljes PDQ-39- pontsz\u00e1mok nem k\u00fcl\u00f6nb\u00f6ztek a csoportok k\u00f6z\u00f6tt, a Mobilit\u00e1s \u00e9s a Kogn\u00edci\u00f3 aldom\u00e9nek szignifik\u00e1nsan nagyobb m\u00e9rt\u00e9k\u0171 k\u00e1rosod\u00e1st mutattak az anosmi\u00e1s betegekn\u00e9l. A s\u00f3s \u00edz \u00e9rz\u00e9kel\u00e9se \u00e9s a depressz\u00edv t\u00fcnetek s\u00falyoss\u00e1ga k\u00f6z\u00f6tt gyenge negat\u00edv korrel\u00e1ci\u00f3t tal\u00e1ltak.\n\nK\u00f6vetkeztet\u00e9s\nAz eredm\u00e9nyek alapj\u00e1n a PD-ben fenn\u00e1ll\u00f3 anosmia szelekt\u00edven \u00f6sszef\u00fcgg az umami\u00edz-\u00e9rz\u00e9kel\u00e9s roml\u00e1s\u00e1val, valamint bizonyos nem motoros t\u00fcneti dom\u00e9nek \u2013 k\u00fcl\u00f6n\u00f6sen az affekci\u00f3 \u00e9s a motiv\u00e1ci\u00f3 \u2013 fokozott \u00e9rintetts\u00e9g\u00e9vel. Ez egy jellegzetes, a kemopercepci\u00f3s zavarokhoz kapcsol\u00f3d\u00f3, nem motoros t\u00fcneti profilra utal. Parkinson-k\u00f3rban az objekt\u00edven meghat\u00e1rozott anosmia szelekt\u00edv umami\u00edz-\u00e9rz\u00e9kel\u00e9si zavarral, valamint a depressz\u00edv \u00e9s egy\u00e9b nem motoros t\u00fcnetek nagyobb terh\u00e9vel t\u00e1rsul, ami arra utal, hogy a kemopercepci\u00f3s diszfunkci\u00f3 klinikailag relev\u00e1ns nem motoros t\u00fcneti profilt jelez.<\/jats:p>","DOI":"10.18071\/isz.79.0315","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:32:18Z","timestamp":1790076738000},"page":"315-326","source":"Crossref","is-referenced-by-count":0,"title":["Szelekt\u00edv umami-\u00edz\u00e9rz\u00e9kel\u00e9si zavar anosmi\u00e1s Parkinson-k\u00f3rban: \u00f6sszef\u00fcgg\u00e9sek a nem motoros t\u00fcnetekkel"],"prefix":"10.18071","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3627-5212","authenticated-orcid":false,"given":"Zehra","family":"Yavuz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil","family":"\u00d6nder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Ak\u00e7elebi Eldek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selim Sel\u00e7uk","family":"\u00c7omoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7411","published-online":{"date-parts":[[2026]]},"container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"original-title":[],"link":[{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/selective-umami-taste-impairment-in-anosmic-parkinsons-disease-associations-with-non-motor-symptoms\/pdf-open","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:32:19Z","timestamp":1790076739000},"score":1,"resource":{"primary":{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/selective-umami-taste-impairment-in-anosmic-parkinsons-disease-associations-with-non-motor-symptoms"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"9-10","published-online":{"date-parts":[[2026]]},"published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.18071\/isz.79.0315","relation":{},"ISSN":["0019-1442","2498-6208"],"issn-type":[{"value":"0019-1442","type":"print"},{"value":"2498-6208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}