{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:11:31Z","timestamp":1790079091836,"version":"4.0.1"},"reference-count":0,"publisher":"Ideggyogyaszati Szemle Journal","issue":"9-10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Bevezet\u00e9s\nA migr\u00e9nes betegekben a sziszt\u00e9m\u00e1s gyullad\u00e1sos elt\u00e9r\u00e9seket csak korl\u00e1tozott sz\u00e1m\u00fa vizsg\u00e1latban \u00edrt\u00e1k le, \u00e9s az erre vonatkoz\u00f3 bizony\u00edt\u00e9kok nem egys\u00e9gesek. Ebben az \u00f6sszef\u00fcgg\u00e9sben az \u00e9retlen granulocyt\u00e1kat (immature granulocyte, IG), amelyek a csontvel\u0151i aktiv\u00e1ci\u00f3 korai indik\u00e1torai, a migr\u00e9nkutat\u00e1s potenci\u00e1lis biomarkereik\u00e9nt vetett\u00e9k fel. A jelen vizsg\u00e1lat c\u00e9lja az IG-szintek \u00e9rt\u00e9kel\u00e9se epizodikus migr\u00e9nben szenved\u0151 betegekben a migr\u00e9nes roham alatt \u00e9s az interictalis id\u0151szakban, valamint az IG-szintek \u00e9s a hematol\u00f3giai gyullad\u00e1sos markerek, illetve a klinikai jellemz\u0151k k\u00f6z\u00f6tti \u00f6sszef\u00fcgg\u00e9sek vizsg\u00e1lata volt.\n\nM\u00f3dszerek\nEbbe a prospekt\u00edv, eset-kontroll vizsg\u00e1latba 53 epizodikus migr\u00e9nben szenved\u0151 beteget \u00e9s \u00e9letkor, illetve nem szerint illesztett 53 eg\u00e9szs\u00e9ges kontrollszem\u00e9lyt vontak be. V\u00e9rmint\u00e1kat vettek akut migr\u00e9nes roham alatt \u00e9s a rohammentes id\u0151szakban. Elemezt\u00e9k a gyullad\u00e1sos param\u00e9tereket, t\u00f6bbek k\u00f6z\u00f6tt az IG-szintet, a neutrophil\/lymphocyta ar\u00e1nyt, a thrombocyta\/lymphocyta ar\u00e1nyt, a lymphocyta\/monocyta ar\u00e1nyt (LMR), a sziszt\u00e9m\u00e1s gyullad\u00e1sos v\u00e1laszindexet (SIRI), valamint a thrombocytaindexeket. Vizsg\u00e1lt\u00e1k az \u00f6sszef\u00fcgg\u00e9seket olyan klinikai jellemz\u0151kkel, mint a fejf\u00e1j\u00e1s gyakoris\u00e1ga, az aura jelenl\u00e9te, a feh\u00e9r\u00e1llom\u00e1nyi laesi\u00f3k \u00e9s a migr\u00e9n okozta funkci\u00f3k\u00e1rosod\u00e1s m\u00e9r\u00e9s\u00e9re szolg\u00e1l\u00f3 MIDAS-pontsz\u00e1m.\n\nEredm\u00e9nyek\nAz IG-szintek nem k\u00fcl\u00f6nb\u00f6ztek szignifik\u00e1nsan a migr\u00e9nes betegek \u00e9s a kontrollszem\u00e9lyek k\u00f6z\u00f6tt. Ugyanakkor az alacsonyabb IG-szintek magasabb fejf\u00e1j\u00e1s-gyakoris\u00e1ggal (\u03c1 = \u22120,453; p = 0,001) \u00e9s magasabb MIDAS-pontsz\u00e1mmal (\u03c1 = \u22120,291; p = 0,037) mutattak \u00f6sszef\u00fcgg\u00e9st. Az LMR szignifik\u00e1nsan alacsonyabb, m\u00edg a SIRI magasabb volt a roham alatti betegekben a kontrollokhoz k\u00e9pest (p = 0,028, illetve p = 0,023). A thrombocytaindexek, p\u00e9ld\u00e1ul az MPV, a PDW \u00e9s a P-LCR, emelkedtek a rohamok alatt, m\u00edg a thrombocytasz\u00e1m a rohammentes id\u0151szakban n\u00f6vekedett. A ROC-anal\u00edzisek alapj\u00e1n a thrombocytaindexek diszkrimin\u00e1ci\u00f3s k\u00e9pess\u00e9ge korl\u00e1tozott volt (AUC &lt; 0,61).\n\nK\u00f6vetkeztet\u00e9s\nAz eredm\u00e9nyek arra utalnak, hogy az IG-szintek, valamint az olyan gyullad\u00e1sos indexek, mint az LMR \u00e9s a SIRI, t\u00fckr\u00f6zhetik a migr\u00e9nnel \u00f6sszef\u00fcgg\u0151 immunaktivit\u00e1st \u00e9s a betegs\u00e9gterhel\u00e9st a migr\u00e9nes roham f\u00e1zis\u00e1ban. Klinikai alkalmazhat\u00f3s\u00e1guk meg\u00edt\u00e9l\u00e9s\u00e9hez azonban tov\u00e1bbi valid\u00e1ci\u00f3s vizsg\u00e1latok sz\u00fcks\u00e9gesek.<\/jats:p>","DOI":"10.18071\/isz.79.0329","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:32:18Z","timestamp":1790076738000},"page":"329-339","source":"Crossref","is-referenced-by-count":0,"title":["Az \u00e9retlen granulocyt\u00e1k szerepe \u00faj biomarkerk\u00e9nt migr\u00e9nben: prospekt\u00edv, harmadlagos ell\u00e1t\u00e1si szint\u0171 tanulm\u00e1ny"],"prefix":"10.18071","volume":"79","author":[{"given":"Mehmet Akif","family":"Bildirici","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O\u011fuzhan","family":"Durgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130mran Sona","family":"Ayval\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7411","published-online":{"date-parts":[[2026]]},"container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"original-title":[],"link":[{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/the-role-of-immature-granulocytes-as-a-novel-biomarker-in-migraine-a-prospective-tertiary-care-study\/pdf-open","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:32:19Z","timestamp":1790076739000},"score":1,"resource":{"primary":{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/the-role-of-immature-granulocytes-as-a-novel-biomarker-in-migraine-a-prospective-tertiary-care-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"9-10","published-online":{"date-parts":[[2026]]},"published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.18071\/isz.79.0329","relation":{},"ISSN":["0019-1442","2498-6208"],"issn-type":[{"value":"0019-1442","type":"print"},{"value":"2498-6208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}