{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:09:51Z","timestamp":1790078991003,"version":"4.0.1"},"reference-count":0,"publisher":"Ideggyogyaszati Szemle Journal","issue":"9-10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>A Miller\u2013Fisher-szindr\u00f3ma (MFS) a Guillain\u2013 Barr\u00e9-szindr\u00f3ma (GBS) ritka vari\u00e1nsa. A GBS akut, immunmedi\u00e1lt perif\u00e9ri\u00e1s neuropathia, amit az esetek t\u00f6bbs\u00e9g\u00e9ben fert\u0151z\u00e9s el\u0151z meg, k\u00fcl\u00f6n\u00f6sen Campylobacter jejuni okozta fert\u0151z\u00e9s. Kialakul\u00e1s\u00e1nak h\u00e1tter\u00e9ben els\u0151sorban autoimmun mechanizmus \u00e1ll, amelyben a molekul\u00e1ris mimikri jelent\u0151s szerepet j\u00e1tszik. Az antigangliozid-antitestek fontos szerepet t\u00f6ltenek be az MFS patogenezis\u00e9ben; az \u00e9rintett betegek k\u00f6r\u00e9ben k\u00fcl\u00f6n\u00f6sen gyakoriak az anti-GQ1b antitestek. Ugyanakkor m\u00e1s antigangliozid-antitestek jelenl\u00e9te nem z\u00e1rja ki az MFS diagn\u00f3zis\u00e1t.\n\nEgy 72 \u00e9ves f\u00e9rfi eset\u00e9t ismertetj\u00fck, aki akutan kialakult diplopi\u00e1val \u00e9s mindk\u00e9t szemen fokoz\u00f3d\u00f3 l\u00e1t\u00e1szavarral, valamint j\u00e1r\u00e1sbizonytalans\u00e1ggal jelentkezett. A t\u00fcnetek megjelen\u00e9se el\u0151tt k\u00f6r\u00fclbel\u00fcl k\u00e9t h\u00e9ttel gastroenteritisen esett \u00e1t. A neurol\u00f3giai vizsg\u00e1lat minden tekint\u00e9si ir\u00e1nyban jelentkez\u0151, s\u00falyos diplopi\u00e1val j\u00e1r\u00f3, csaknem teljes ophthalmoplegi\u00e1t, a v\u00e9gtagokon generaliz\u00e1lt hyporeflexi\u00e1t, valamint koordin\u00e1ci\u00f3s zavart igazolt. A cerebrospinalis folyad\u00e9k vizsg\u00e1lata nem mutatott k\u00f3ros elt\u00e9r\u00e9st.\n\nAz antigangliozid-antitestek vizsg\u00e1lat\u00e1t ELISA m\u00f3dszerrel v\u00e9gezt\u00fck, GM1, GM2, GM3, GD1a, GD1b, GT1b \u00e9s GQ1b elleni antitestek kimutat\u00e1s\u00e1ra. Az eredm\u00e9nyek az anti-GM3 IgG-antitestek izol\u00e1lt, er\u0151s (+++) pozitivit\u00e1s\u00e1t mutatt\u00e1k. A klinikai k\u00e9p \u00e9s a szerol\u00f3giai eredm\u00e9nyek alapj\u00e1n Miller\u2013Fisher-szindr\u00f3ma diagn\u00f3zis\u00e1t \u00e1ll\u00edtottuk fel. Az antigangliozid-antitestek jelenl\u00e9te t\u00e1mogathatja az MFS diagn\u00f3zis\u00e1t, azonban a diagn\u00f3zis tov\u00e1bbra is els\u0151sorban klinikai alapon \u00e1ll\u00edthat\u00f3 fel.<\/jats:p>","DOI":"10.18071\/isz.79.0347","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:32:18Z","timestamp":1790076738000},"page":"347-349","source":"Crossref","is-referenced-by-count":0,"title":["Anti-GM3 IgG-antitestekkel \u00f6sszefu\u0308gg\u0151 Miller\u2013Fisher-szindr\u00f3ma els\u0151 esete: klasszikus tri\u00e1d \u00e9s atipikus immunv\u00e1lasz"],"prefix":"10.18071","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3674-7643","authenticated-orcid":false,"given":"Bet\u00fcl","family":"\u00d6zenc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erman","family":"Altunisik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyza","family":"Musabeyoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7411","published-online":{"date-parts":[[2026]]},"container-title":["Ideggy\u00f3gy\u00e1szati szemle"],"original-title":[],"link":[{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/the-first-case-of-miller-fisher-syndrome-associated-with-anti-gm3-igg-antibodies-classic-triad-and-an-atypical-immune-response\/pdf-open","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:32:19Z","timestamp":1790076739000},"score":1,"resource":{"primary":{"URL":"https:\/\/elitmed.hu\/en\/publications\/clinical-neuroscience\/the-first-case-of-miller-fisher-syndrome-associated-with-anti-gm3-igg-antibodies-classic-triad-and-an-atypical-immune-response"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"9-10","published-online":{"date-parts":[[2026]]},"published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.18071\/isz.79.0347","relation":{},"ISSN":["0019-1442","2498-6208"],"issn-type":[{"value":"0019-1442","type":"print"},{"value":"2498-6208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}