{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:30:51Z","timestamp":1793640651655,"version":"4.5.1"},"reference-count":12,"publisher":null,"issue":"12","license":[{"start":{"date-parts":[[2018,12,25]],"date-time":"2018-12-25T00:00:00Z","timestamp":1545696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    to elucidate predictors of development of chronic thromboembolic pulmonary hypertension (CTEPH) after acute pulmonary artery thromboembolism (PTE).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Material and methods<\/jats:bold>\n                    . We included in this study 210 patients hospitalized with\u00a0diagnosis of\u00a0submassive and massive PTE from 2013 to 2017. In 1\u00a0to\u00a03\u00a0years after initial hospitalization these patients were invited for control examination. According to results of this examination patients were divided into two groups: with (group 1, n=45) and without (group 2, n=165) signs of CTEPH. Severity of\u00a0pulmonary artery vascular bed involvement was assessed by\u00a0multislice computed tomography (MSCT) angiography and lung scintigraphy. For detection of thrombosis in the inferior vena cava system we used ultrasound angioscanning. \u00a0\u00a0Examination also included echocardiography.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results.<\/jats:bold>\n                    In\u00a0the\u00a0process of mathematical analysis, the following risk factors for the development of CTEPH embolism were determined: duration of thrombotic history (group 1 \u2013 13.70\u00b12.05 days, group 2\u2013 16.16\u00b11.13\u00a0days, p=0.015), localization of venous thrombosis in the lower extremities (the most favorable\u00a0\u2013 shin veins, popliteal, and common femoral veins, unfavorable\u00a0\u2013 superficial femoral vein). The choice of the drug for thrombolytic and anticoagulant therapy: streptokinase and urokinase were significantly more effective than alteplase, rivaroxaban was superior to the combination of unfractionated or\u00a0low molecular weight heparins with warfarin. Also, risk factors for the development of CTEPH were the initial degree of pulmonary hypertension and tricuspid insufficiency, as well as the positive dynamics of these indicators at the background of thrombolytic or\u00a0anticoagulant therapy. Of concomitant diseases, significant risk factors for development of CTEPH were grade 3 hypertensive disease, diabetes mellitus, post\u00adinfarction cardiosclerosis. On\u00a0the\u00a0other hand, age, gender, degree of severity at the time of admission, presence of\u00a0infarction pneumonia, surgical prevention of recurrent pulmonary embolism, number of pregnancies and deliveries, history of\u00a0trauma and malignancies, cardiac arrhythmias produced no\u00a0significant impact on the development of CTEPH.\n                  <\/jats:p>","DOI":"10.18087\/cardio.2018.12.10206","type":"journal-article","created":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T02:34:46Z","timestamp":1545964486000},"page":"60-65","source":"Crossref","is-referenced-by-count":3,"title":["Predictors of Chronic Thromboembolic Pulmonary Hypertension"],"prefix":"10.68900","volume":"58","author":[{"given":"M. R.","family":"Kuznetsov","sequence":"first","affiliation":[{"name":"Pirogov Russian National Research Medical University (RNRMU)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. V.","family":"Reshetov","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. B.","family":"Orlov","sequence":"additional","affiliation":[{"name":"Pirogov Russian National Research Medical University (RNRMU)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Khotinsky","sequence":"additional","affiliation":[{"name":"Pirogov Russian National Research Medical University (RNRMU)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Atayan","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Shchedrin\u0430","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2018,12,25]]},"reference":[{"key":"ref1","unstructured":"Russian clinical guidelines for the diagnosis, treatment and prevention of venous thromboembolic complications (VTE). Phlebology 2015;4:3-52. Russian"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Garcia Sabrido J. L., Pacheco Sanchez D. Profilaxis de la enferme-dad tromboemb\u043elica perioperatoria en cirugta general. Cir Esp 2001;69:49-55.","DOI":"10.1016\/S0009-739X(01)71686-7"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Duranteau J., Taccone F. S., Verhamme P., Ageno W. European guidelines on perioperative venous thromboembolism prophylaxis: Intensive care. Eur J Anaesthesiol 2018;35 (2):142-146.","DOI":"10.1097\/EJA.0000000000000707"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Al Yami M. S., Silva M. A., Donovan J. L., Kanaan A. O. Venous thromboembolism prophylaxis in medically ill patients: a mixed treatment comparison meta-analysis. J Thromb Thrombolysis 2018;45 (1):36-47.","DOI":"10.1007\/s11239-017-1562-5"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Kim N. H., Delcroix M., Jenkins D. P. et al. Chronic thromboembolic pulmonary hypertension. J Am Coll Cardiol 2013;62: D92-D99.","DOI":"10.1016\/j.jacc.2013.10.024"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Pepke-Zaba J., Delcroix M., Lang I. et al. Chronic thromboembolic pulmonary hypertension (CTEPH): results from an international prospective registry. Circulation 2011;124:1973-1981.","DOI":"10.1161\/CIRCULATIONAHA.110.015008"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Chazova I. E., Martynyuk T. V. Clinical guidelines for the diagnosis and treatment of chronic thromboembolic pulmonary hypertension (Part I). Therapeutic Archive 2016;9:90-101. Russian","DOI":"10.17116\/terarkh201688990-101"},{"key":"ref8","unstructured":"Saveliev V. S. Massive pulmonary embolism. V S. Saveliev, E. G. Yablokov, A. I. Kiriyenko. M 1990;336p. Russian"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Poch D. S., Auger W. R. Chronic thromboembolic pulmonary hypertension: detection, medical and surgical treatment approach, and current outcomes. Heart Fail Rev 2016; May;21 (3):309-22. DOI: 10.1007\/s10741-015-9518-3.","DOI":"10.1007\/s10741-015-9518-3"},{"key":"ref10","unstructured":"Yang S., Yang Y., Zhai Z. et al. Incidence and risk factors of chronic thromboembolic pulmonary hypertension in patients after acute pulmonary embolism. J Thorac Dis 2015;7 (11):1927-1938. DOI: 10.3978\/j.issn.2072-1439.2015.11.43."},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Konstantinides C. V., Torbick A., Giancarlo Agnelli G. et al. 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism. Eur Heart J 2014;35:3033-3080.","DOI":"10.1093\/eurheartj\/ehu283"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Pengo V., Lensing A. W., Prins M. H. et al. Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism. N Engl J Med 2004;350:2257-2264.","DOI":"10.1056\/NEJMoa032274"}],"container-title":["Kardiologiia"],"original-title":[],"link":[{"URL":"https:\/\/lib.ossn.ru\/jour\/article\/viewFile\/376\/330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:16:27Z","timestamp":1793639787000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardio.elpub.ru\/jour\/article\/view\/376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,25]]},"references-count":12,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,25]]}},"URL":"https:\/\/doi.org\/10.18087\/cardio.2018.12.10206","relation":{},"ISSN":["2412-5660","0022-9040"],"issn-type":[{"value":"2412-5660","type":"electronic"},{"value":"0022-9040","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12,25]]}}}