{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:31:33Z","timestamp":1793640693254,"version":"4.5.1"},"reference-count":28,"publisher":null,"issue":"1","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>In a group of 32 patients with combined ischemic heart disease (IHD) and arterial hypertension (AH) we studied dynamics of parameters of blood pressure and ECG 24-hour monitoring, as well as ultrasound structural and functional parameters of left and right ventricles during 3-month therapy with fixed dose combination of perindopril arginine (10.0 mg) and amlodipine (5.0 mg). The obtained results demonstrated significant positive effect of this combination on the geometry, structure and diastolic function of both left and right ventricles, as well as confirmed its high antiischemic and antihypertensive effects.<\/jats:p>","DOI":"10.18087\/cardio.2019.1.10212","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T06:38:03Z","timestamp":1548657483000},"page":"22-27","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Perindopril \/ Amlodipine Fixed Combination on Ultrasound Characteristics of Ventricles of the Heart in Patients with Ischemic Heart Disease and Arterial Hypertension"],"prefix":"10.68900","volume":"59","author":[{"given":"N. V.","family":"Drobotya","sequence":"first","affiliation":[{"name":"Rostov State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. S.","family":"Torosyan","sequence":"additional","affiliation":[{"name":"Rostov State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Sh.","family":"Guseynova","sequence":"additional","affiliation":[{"name":"Rostov State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. N.","family":"Morgunov","sequence":"additional","affiliation":[{"name":"Rostov State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Kovalevskaya E. A., Krylova N. S., Poteshkina N. G. Hypertrophic cardiomyopathy and ischemic heart disease: the problem of pathology combination. Kardiologiya 2018;58(S1):31\u201335. Russian (Kovalevskaya E. A., Krylova N. S., Poteshkina N. G. Gipertroficheskaya kardiomiopatiya i ishemicheskaya bolezn' serdtsa: problema sochetaniya patologii. 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Terapevticheskii arkhiv 2018;90(4):29\u201334).","DOI":"10.26442\/terarkh201890429-34"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Ostroumova O. D., Kochetkov A. I., Guseva T. F. Blood pressure variability in hypertension associated with coronary heart disease: prognostic value and management approaches. Arterial Hypertension 2018;24(2):246\u2013256. Russian (Ostroumova O. D., Kochetkov A. I., Guseva T. F. Variabel'nost' arterial'nogo davleniya pri arterial'noi gipertenzii v sochetanii s ishemicheskoi bolezn'yu serdtsa: prognosticheskaya znachimost' i vozmozhnosti korrektsii v real'noi klinicheskoi praktike. Arterial'naya gipertenziya 2018;24(2):246\u2013256).","DOI":"10.18705\/1607-419X-2018-24-2-246-256"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Dzau V., Braunwald E. Resolved and unresolved issues in the prevention and treatment of coronary artery disease: a workshop consensus statement. 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V., Ageev F. T. Left ventricular dysfunction in hypertensive heart: Current view of the pathogenesis and treatment. Kardiologiya 2017;57(S2):367\u2013 382. Russian (Ovchinnikov A. G., Potekhina A. V., Ozherel'eva M. V., Ageev F. T. Disfunktsiya levogo zheludochka pri gipertonicheskom serdtse: sovremennyi vzglyad na patogenez i lechenie. Kardiologiya 2017;57(S2):367\u2013382).","DOI":"10.18087\/cardio.2393"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Braunvald E., Kloner R.A. The stunned myocardium: Prolonged, postischemic ventricular dysfunction. Circulation 1982;66:1146\u20131149.","DOI":"10.1161\/01.CIR.66.6.1146"},{"key":"ref10","unstructured":"Bokeria L. A., Rabotnikov V. S., Buziashvili Yu. I. et al. Ischemic heart disease in patients with low myocardial contractility of the left ventricle (diagnosis, tactics of treatment). M.: NCSSH im. A. N. Bakuleva RAMN, 2001:195. Russian (Bokeriya L. A., Rabotnikov V. S., Buziashvili Yu. I. i dr. Ishemicheskaya bolezn' serdtsa u bol'nykh s nizkoi sokratitel'noi sposobnost'yu miokarda levogo zheludochka (diagnostika, taktika lecheniya). M.: NTsSSKh im. A.N. Bakuleva RAMN, 2001:195)."},{"key":"ref11","unstructured":"Buslenko N.S., Buziashvili Yu.I., Koksheneva I.V. et al. The relationship between the functional state of the right ventricle and the degree of heart failure in patients with ischemic heart disease with low contractile function of the left ventricle. Kardiologiya 2005;45(12):25\u201330. Russian (Buslenko N.S., Buziashvili Yu.I., Koksheneva I.V. i dr. Vzaimosvyaz' mezhdu funktsional'nym sostoyaniem pravogo zheludochka i stepen'yu serdechnoi nedostatochnosti u bol'nykh ishemicheskoi bolezn'yu serdtsa s nizkoi sokratitel'noi funktsiei levogo zheludochka. Kardiologiya 2005;45(12):25\u201330)."},{"key":"ref12","unstructured":"Buziashvili Yu.I., Asymbekova E.U., Madalimov R.R. et al. The diastolic function of the left and right ventricles in patients with ischemic heart disease and its changes under the influence of angiotensin-converting enzyme inhibitor. Bulletin NCSSH im. A.N. Bakuleva RAMN 2011;12(2):33\u201343. Russian (Buziashvili Yu.I., Asymbekova E.U., Madalimov R.R. i dr. Sostoyanie diastolicheskoi funktsii levogo i pravogo zheludochkov u bol'nykh IBS i ee izmeneniya pod vliyaniem ingibitora angiotenzinprevrashchayushchego fermenta. Byulleten' NTsSSKh im. A.N. Bakuleva RAMN 2011;12(2):33\u201343)."},{"key":"ref13","unstructured":"Drobotya N. V., Koudryashova E. A., Vasilikhina D. V., Kaltykova V. V. Functional characteristics of left and right heart parts in patients with ischemic heart disease and multifocal coronary lesions. Bulletin of the National medical and surgical Center name\u2019s N. I. Pirogov 2014;9(4):32\u201334. Russian (Drobotya N. V., Kudryashova E. A., Vasilikhina D. V., Kaltykova V. V. Funk tsio nal'nye kharakteristiki levykh i pravykh otdelov serdtsa u bol'nykh ishemicheskoi bolezn'yu serdtsa s mul'tifokal'nym porazheniem koronarnogo rusla. Vestnik Natsional'nogo mediko-khirurgicheskogo Tsentra im. N. I. Pirogova 2014;9(4):32\u201334)."},{"key":"ref14","unstructured":"Drobotya N. V., Koudryashova E. A. Effect of coronary bypass surgery on the structural and functional state of the left and right ventricles in patients with ischemic heart disease. RMJ. Kardiologiya 2015;15:914\u2013918. Russian (Drobotya N. V., Kudryashova E. A. Vliyanie koronarnogo shuntirovaniya na strukturno-funktsional'noe sostoyanie levogo i pravogo zheludochkov u bol'nykh ishemicheskoi bolezn'yu serdtsa. RMZh. Kardiologiya 2015; 15:914\u2013918)."},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Islamova M. R., Lazarev P. V., Safarova A. F., Kobalava Zh. D. The value of right ventricular dysfunction and right ventricularpulmonary artery coupling in chronic heart failure: the role of echocardiography. Kardiologiia 2018;58(5):82\u201390. Russian (Islamova M. R., Lazarev P. V., Safarova A. F., Kobalava Zh. D. Znachenie disfunktsii pravogo zheludochka, pravozheludochkovo-arterial'nogo sopryazheniya pri khronicheskoi serdechnoi nedostatochnosti: rol' ekhokardiografii. Kardiologiya 2018;58(5):82\u201390).","DOI":"10.18087\/cardio.2018.5.10124"},{"key":"ref16","unstructured":"Bokeria L. A., Gudkova R. G. Cardiovascular surgery. M.: NCSSH im. A. N. Bakuleva RAMN, 2013:200. Russian (Bokeriya L. A., Gudkova R. G. Serdechno-sosudistaya khirurgiya. M: NTsSSKh im. A. N. Bakuleva RAMN 2013; 200)."},{"key":"ref17","unstructured":"Diagnosis and treatment of arterial hypertension. Clinical guidelines. M., 2013:63. Russian (Diagnostika i lechenie arterial'noi gipertonii. Klinicheskie rekomendatsii. 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Lancet 2003;(262):782\u2013788.","DOI":"10.1016\/S0140-6736(03)14286-9"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Nissen S. E., Tuzcu E. M., Libby P. et al. Effect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure: the CAMELOT study: a randomised controlled trial. JAMA 2004;292(18):2217\u20132225.","DOI":"10.1001\/jama.292.18.2217"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Dahlof B., Sever P. S., Poulter N. R. et al. Prevention of cardiovascular events with an antihypertensive regimes of amlodipine adding perindopril versus atenolol adding bendroflumethiazide as required in ASCOT-BPLA: multicentre randomised controlled trial. Lancet 2005;366(9489):895\u2013906.","DOI":"10.1016\/S0140-6736(05)67185-1"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Bertrand M. E., Ferrari R., Remme W. J. et al. Clinical Synergy of Perindopril and Calcium channel Blocker in the Prevention of Cardiac Events and Mortality in Patients with Coronary Artery Disease. Post Hoc Analysis of the EUROPA Study. Am Heart J 2010;159(5):795\u2013802.","DOI":"10.1016\/j.ahj.2009.12.042"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Bezuglova E. I., Luneva Yu. V., Kornilov A. A., Povetkin S. V. Assessment of efficacy of combined pharmacotherapy with fixed perindopril\/amlodipine combination in patients with combined cardiovascular pathology in outpatient practice. Kardiologiya 2018;58(3):37\u201342. Russian (Bezuglova E. I., Luneva Yu. V., Kornilov A. A., Povetkin S. V. Otsenka effektivnosti kombinirovannoi farmakoterapii s ispol'zovaniem fiksirovannoi kombinatsii perindopril\/amlodipin u bol'nykh s sochetannoi serdechno-sosudistoi patologiei v usloviyakh obychnoi ambulatornoi praktiki. Kardiologiya 2018;58(3):37\u201342).","DOI":"10.18087\/cardio.2018.3.10097"},{"key":"ref26","unstructured":"Fatenkov V. N. A new look at the heart biomechanics. Cardiology and cardiovascular surgery 2009;5:65\u201371. Russian (Fatenkov V. N. Novyi vzglyad na biomekhaniku serdtsa. Kardiologiya i serdechno-sosudistaya khirurgiya 2009;5:65\u201371)."},{"key":"ref27","unstructured":"Vasyuk Y. A., Kozina A. A. Peculiarities of diastolic function and remodeling in patients with arterial hypertension. Heart failure 2003;4(2):79\u201380. Russian (Vasyuk Yu. A., Kozina A. A. Osobennosti diastolicheskoi funktsii i remodelirovaniya u bol'nykh s arterial'noi gipertoniei. Serdechnaya nedostatochnost' 2003;4(2):79\u201380)."},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Mrikaev D. V. Left ventricular diastolic dysfunction in patients with heart failure. Creative Cardiology 2017;11(2):145\u201358. Russian (Mrikaev D. V. Diastolicheskaya disfunktsiya levogo zheludochka u bol'nykh c serdechnoi nedostatochnost'yu. Kreativnaya kardiologiya 2017;11(2):145\u201358).","DOI":"10.24022\/1997-3187-2017-11-2-145-158"}],"container-title":["Kardiologiia"],"original-title":[],"link":[{"URL":"https:\/\/lib.ossn.ru\/jour\/article\/viewFile\/426\/344","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:16:29Z","timestamp":1793639789000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardio.elpub.ru\/jour\/article\/view\/426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,28]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,28]]}},"URL":"https:\/\/doi.org\/10.18087\/cardio.2019.1.10212","relation":{},"ISSN":["2412-5660","0022-9040"],"issn-type":[{"value":"2412-5660","type":"electronic"},{"value":"0022-9040","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1,28]]}}}