{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:31:56Z","timestamp":1793640716706,"version":"4.5.1"},"reference-count":26,"publisher":null,"issue":"11","license":[{"start":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T00:00:00Z","timestamp":1576368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>\n                    <jats:italic>Aim.<\/jats:italic>\n                    The aim of the study is to evaluate important additional cardiovascular (CV) risk factors of major adverse cardiac events (MACE) in patients with acute coronary syndrome (ACS) during the first 30 days after index event.\n                    <jats:italic>Materials and methods.<\/jats:italic>\n                    Overall 750 patients with ACS were enrolled in the single center prospective registry from 2012-2015yy. 569 patients received dual antiplatelet therapy and in 425 cases platelet function testing (PFT) were performed. Most of the patients characterized as high risk elderly patients with multiple CV risk factors and high comorbidity index.\n                    <jats:italic>Results.<\/jats:italic>\n                    At 30-day follow-up the mortality rate was 10,1%. Singlevariate analysis showed strong association between MACE and age, atrial fibrillation, stroke, chronic kidney disease, low ejection fraction, type 2 myocardial infarction (T2MI). Multivariate analysis showed that high-on-treatment platelet reactivity (PFT&gt; 45%) with odds ratio 4.418 (p=0.0001), chronic kidney disease (OR 6.538 p=0.001) and T2MI (OR 1.925 p=0.0001) were significantly associated with adverse outcome.\n                    <jats:italic>Conclusion.<\/jats:italic>\n                    ACS registry showed high mortality level in real-life practice compared with randomized clinical trials due to the high prevalence of elderly patients with high comorbidity index. Patients with T2MI have significantly more severe prognosis and chronic kidney disease associated with increased MACE. PFT in this category of patients is reasonable for more accurate risk stratification.\n                  <\/jats:p>","DOI":"10.18087\/cardio.2019.11.n723","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T05:48:20Z","timestamp":1576648100000},"page":"14-20","source":"Crossref","is-referenced-by-count":1,"title":["Acute Coronary Syndrome Registry of High Risk Patients: 30-Day Outcome"],"prefix":"10.68900","volume":"59","author":[{"given":"N. V.","family":"Lomakin","sequence":"first","affiliation":[{"name":"Central Clinical Hospital of the Management Affair of President RF"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. I.","family":"Buryachkovskaya","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Cardiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. B.","family":"Sumarokov","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Cardiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. N.","family":"Gerasimov","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. A.","family":"Gabbasov","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Cardiology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2019,12,15]]},"reference":[{"key":"ref1","unstructured":"Yusuf S, Flather M, Pogue J, Hunt D, Varigos J, Piegas L et al. Variations between countries in invasive cardiac procedures and outcomes in patients with suspected unstable angina or myocardial infarction without initial ST elevation. The Lancet. 1998;352(9127):507\u201314. 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