{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:31:55Z","timestamp":1793640715148,"version":"4.5.1"},"reference-count":22,"publisher":null,"issue":"3","license":[{"start":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T00:00:00Z","timestamp":1555113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>Aim: to study relationship between genetic disorders and features of intrarenal blood flow in patients with essential arterial hypertension\u00a0(AH) of 1\u20132 degree. Materials and methods. We examined 100 patients (60 women, 40 men) aged 35 to 58 years with 1\u20132\u2011degree essential\u00a0arterial hypertension (AH) and chronic kidney disease (CKD) stages I\u2013III. Examination included triplex scanning of renal arteries\u00a0on the ultrasound scanner Vivid-7 Dimension, genotyping of single-nucleotide polymorphism \u04101166\u0421 of the AGTR1 gene by real\u00a0time polymerase chain reaction (PCR), estimation of glomerular filtration rate (GFR) using CKD-EPI formula. Patients were divided\u00a0into 2 groups: group 1 included persons with I and II stage CKD (n=65, 25 men and 40 women), group 2 included patients with stages\u00a0IIIA and IIIB CKD (n=35, 15 men and 20 women). Results. Among patients of group 1 prevailed genotype AA, while among group 2\u00a0patients prevailed genotype AC. Speed of blood flow in interlobar renal arteries was higher in the group 1 compared with group 2, while\u00a0in the group 2 time of acceleration of blood flow was higher than in the group 1. Discussion. The data obtained are indicative of the decrease\u00a0of systolic, diastolic, and averaged maximal blood flow velocity and the lengthening of acceleration time in patients with higher\u00a0CKD stage. Conclusions. The presence in the genotype of patients with 1\u20132\u2011degree AH of AGTR1 1166\u0421 allele may be considered a risk\u00a0factor of early development of CKD. Lowering of speed characteristics of blood flow and lengthening of the acceleration time in patients\u00a0with AH can be a criterion of hypertensive nephropathy development.<\/jats:p>","DOI":"10.18087\/cardio.2019.3.10233","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T05:07:35Z","timestamp":1555391255000},"page":"5-10","source":"Crossref","is-referenced-by-count":3,"title":["Polymorphism A1166C of AGTR1 Gene and the State of Intrarenal Blood Flow in Patients with Essential Arterial Hypertension 1\u20132 Degrees"],"prefix":"10.68900","volume":"59","author":[{"given":"L. V.","family":"Melnikova","sequence":"first","affiliation":[{"name":"Penza Institute for Further Training of Physicians \u2013 Branch Campus of the Russian Medical Academy of Continuous Professional Education"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. V.","family":"Osipova","sequence":"additional","affiliation":[{"name":"Penza Institute for Further Training of Physicians \u2013 Branch Campus of the Russian Medical Academy of Continuous Professional Education"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. A.","family":"Levashova","sequence":"additional","affiliation":[{"name":"Penza Institute for Further Training of Physicians \u2013 Branch Campus of the Russian Medical Academy of Continuous Professional Education"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2019,4,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Sethupathy P., Borel C., Gagnebin M. et al. Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3\u2019 untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes. Am J Hum Genet 2007;81(2):405\u2013413.","DOI":"10.1086\/519979"},{"key":"ref2","unstructured":"Nauchno-organizacionnyj komitet proekta EHSSE-RF. EHpidemiologiya serdechno-sosudistyh zabolevanij v razlichnyh regionah Rossii (EHSSE-RF). Obosnovanie i dizajn issledovaniya. Profilakticheskaya medicina 2013;6:25\u201334. Russian."},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Chazova I. E., Zhernakova Yu. V., Oshchepkova E. V. et al. Rasprostranennost\u2019 faktorov riska razvitiya serdechno-sosudistyh zabolevanij v rossijskoj populyacii bol\u2019nyh arterial\u2019noj gipertoniej. Kardiologiya 2014;10:4\u201312. Russian.","DOI":"10.18565\/cardio.2014.10.4-12"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Fogo A. Mechanisms of progression of chronic kidney disease. Pediatr Nephrol 2007;22:2011\u20132022.","DOI":"10.1007\/s00467-007-0524-0"},{"key":"ref5","unstructured":"Levey A., Greene T., Beck G. et al. for the Modification of Diet in Renal Disease Study Group. Dietary protein restriction and the progression of chronic renal disease; what have all the results of the MDRD study shown? J Am Soc Nephrol  1999;10:2426\u20132439."},{"key":"ref6","unstructured":"Logacheva I. V., Maksimov N. I., Chernyh Yu. V. i dr. Gipertonicheskaya nefropatiya: principy diagnostiki i lecheniya. Prakticheskaya medicina 2011;1(49):42\u201345. Russian."},{"key":"ref7","unstructured":"Dolgih V.V., Kolesnikova L.I. Patogenez ehssencial\u2019noj arterial\u2019noj gipertenzii u detej. Irkutsk: Izd-vo VSNC SO RAMN 1999;218s. Russian."},{"key":"ref8","unstructured":"Pahomya N.S., Uryas\u2019ev O.M., Shahanov A.V. Rol\u2019 polimorfizmov nekotoryh genov v realizacii arterial\u2019noj gipertenzii. Zemskij vrach 2014;3\u20134(24):21\u201324. Russian."},{"key":"ref9","unstructured":"Potapov V.E., Logvinov A.K., Zaruckij S.A. et al. Osobennosti raspredeleniya odnonukleotidnyh polimorfizmov genov, associirovannyh s arterial\u2019noj gipertenziej u bol\u2019nyh s hronicheskoj bolezn\u2019yu pochek. Smolenskij medicinskij al\u2019manah  2015;1(1):138. Russian."},{"key":"ref10","unstructured":"Sorokina V. N., Pavliushchik E. A., Chak T. A. et al. Assotsiatsii polimorfizma M235T gena AGT s arterial\u2019noi gipertenziei u muzhchin. Voennaya meditsina  2016;39(2):56\u201359. Russian."},{"key":"ref11","unstructured":"Geneticheskij pasport \u2013 osnova individual\u2019noj i prediktivnoj mediciny pod red. V. S. Baranova. SPb.: N\u2013L 2009;528s. Russian."},{"key":"ref12","unstructured":"Serov V. V., Pal\u2019cev M. A. Pochki i arterial\u2019naya gipertenziya. M.: Meditsina 1993;256s. Russian."},{"key":"ref13","unstructured":"Petersen L., Petersen J., Ladefoged S. et al. The pulsatility index and the resistive index in renal arteries in patients with hypertension and chronic renal failure. Nephrol Dial Transplant 1995;10(11):2060\u20132064."},{"key":"ref14","unstructured":"Grigoryan Z.Eh., Androsova T.A., Evsev\u2019eva M.E. et al. Indeks rezistentnosti mezhdolevyh arterij kak marker porazheniya serdechno-sosudistoj sistemy u bol\u2019nyh s hronicheskoj bolezn\u2019yu pochek. Nefrologiya i dializ 2009;11(2):116\u2013123. Russian."},{"key":"ref15","unstructured":"Nefrologiya: nacional\u2019noe rukovodstvo pod red. N.A. Muhina. M.: GEOTAR-Media 2009;720s. Russian."},{"key":"ref16","unstructured":"Kardiologiya: nacional\u2019noe rukovodstvo pod red. Yu. N. Belenkova, R. G. Oganova. M.: GEOTAR-Media 2008;1232s. Russian."},{"key":"ref17","unstructured":"Sauvain J., Bourscheid D., Pierrat V. et al. Duplex Doppler ultrasonography of intrarenal arteries. Normal and pathological aspects. Ann Radiol (Paris) 1991;34(4):237\u2013247."},{"key":"ref18","unstructured":"Konechnaya E.YA., Nanchikeeva M.L., Gladkaya A.A. et al. Znachenie pokazatelej vnutripochechnoj gemodinamiki u pacientov s ehssencial\u2019noj arterial\u2019noj gipertenziej. Ul\u2019trazvukovaya i funkcional\u2019naya diagnostika 2001;2:83\u201389. Russian."},{"key":"ref19","unstructured":"Nasrullaev M.N., Vaganova G.R., Bayazitova L.I. Vozmozhnosti dopplerografii v diagnostike porazheniya pochek u bol\u2019nyh arterial\u2019noj gipertenziej. Prakticheskaya medicina 2011;4(52):53\u201355. Russian."},{"key":"ref20","unstructured":"Galesic K., Brkljacic B., Sabljar-Matovinovic M. et al. Renal vascular resistance in essential hypertension: duplex-Doppler ultrasonographic evaluation. Angiology 2000;51(8):667\u2013675."},{"key":"ref21","unstructured":"Kolesnikova L.I., Dolgih V.V., Belyaeva E.V. et al. Rol\u2019 A1166S polimorfizma gena AGTR1 v realizacii arterial\u2019noj gipertenzii u detej s glomerulonefritom. Byulleten\u2019 VSNC SO RAMN 2011;3(79):21\u201323. Russian."},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Sethupathy P., Borel C., Gagnebin M. et al. Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3\u2019 untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes. 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