{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:32:05Z","timestamp":1793640725686,"version":"4.5.1"},"reference-count":20,"publisher":null,"issue":"3","license":[{"start":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T00:00:00Z","timestamp":1555113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>\n                    <jats:bold>Aim<\/jats:bold>\n                    : to analyze adherence of FH patients with familial hypercholesterolemia (FH) to the statin therapy and reveal factors, which influence it;\u00a0to assess the degree of target level of low-density lipoprotein cholesterol (LDLCH) achievement by FH patients on statin therapy.\n                    <jats:bold>Materials and\u00a0<\/jats:bold>\n                    <jats:bold>methods<\/jats:bold>\n                    . We included in this study 203 FH patients aged &gt;18 years (mean age 50.0\u00b11.1 years, 82 men). Definite FH was diagnosed in 96 persons,\u00a0in the other patients FH was considered possible. For evaluating the adherence to therapy with statins we used the Morisky-Green questionnaire.\u00a0\n                    <jats:bold>Results<\/jats:bold>\n                    . Among patients with definite FH 57 % were adherent to lipid-lowering therapy, 16 % were partially adherent, and 27 % \u2013 not\u00a0adherent. Target LDLCH levels were achieved in 22.6 % and 12.5 % of patients with definite and possible FH, respectively. Smoking and gender\u00a0were not associated with adherence to statin therapy. Factors associated with higher adherence were age (p=0.000003), arterial hypertension\u00a0(odds ratio [OR] 1.90, 95 % confidence interval [CI] 1.02 to 3.55], p=0.044), ischemic heart disease (IHD) (OR=2.99, 95 %CI 1.50 to 5.97,\u00a0p=0.002), history of myocardial infarction (MI) (OR 5.26, 95 %CI 2.03 to 13.60, p=0.0006), history of myocardial revascularization (OR 20.3,\u00a095 %CI 2.64 to 156.11, p=0.004) and the fact of achieving target LDLCH level (OR 19.93, 95 %CI 7.03 to 56.50, p&lt;0.0001). The main reason\u00a0for the refuse from statin therapy in 87 % of patients was fear of side effects. Main reasons for stopping of ongoing therapy were: myalgia, an increase\u00a0in transaminases, skin rashes, and high cost in 12, 35, 12, and 6 % of patients, respectively. The decision to withdraw therapy with statins\u00a0was made by 29 % of patients by themselves.\n                    <jats:bold>Conclusion<\/jats:bold>\n                    . In this study 57 % of patients with definite FH were adherent to statin therapy. Factors\u00a0associated with increased adherence were age, hypertension, IHD, history of MI, history of myocardial revascularization, achievement of target\u00a0LDLCH level. Target LDLCH levels were achieved by 22.6 and 12.5 %% of patients with definite and possible FH, respectively.\n                  <\/jats:p>","DOI":"10.18087\/cardio.2019.3.10238","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T05:07:35Z","timestamp":1555391255000},"page":"27-35","source":"Crossref","is-referenced-by-count":2,"title":["Lipid Lowering Therapy with Statins in Patients with Heterozygous Familial Hypercholesterolemia"],"prefix":"10.68900","volume":"59","author":[{"given":"V. A.","family":"Korneva","sequence":"first","affiliation":[{"name":"Petrozavodsk State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Yu.","family":"Kuznetsova","sequence":"additional","affiliation":[{"name":"Petrozavodsk State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. P.","family":"Tihova","sequence":"additional","affiliation":[{"name":"Petrozavodsk State University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2019,4,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Mortality in treated heterozygous familial hypercholesterolaemia: implications for clinical management. Scientific Steering Committee on behalf of the Simon Broome Register group. Atherosclerosis 1999;142:105\u2013112.","DOI":"10.1016\/S0021-9150(98)00200-7"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Nordestgaard B.G., Chapman M.J., Humphries S.E. et al. 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JAMA 2007;297(2):177\u2013186.","DOI":"10.1001\/jama.297.2.177"}],"container-title":["Kardiologiia"],"original-title":[],"link":[{"URL":"https:\/\/lib.ossn.ru\/jour\/article\/viewFile\/563\/383","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:17:17Z","timestamp":1793639837000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardio.elpub.ru\/jour\/article\/view\/563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,13]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,4,13]]}},"URL":"https:\/\/doi.org\/10.18087\/cardio.2019.3.10238","relation":{},"ISSN":["2412-5660","0022-9040"],"issn-type":[{"value":"2412-5660","type":"electronic"},{"value":"0022-9040","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4,13]]}}}