{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:24:15Z","timestamp":1791015855119,"version":"4.1.0"},"reference-count":13,"publisher":"APO Society of Specialists in Heart Failure","issue":"3","license":[{"start":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T00:00:00Z","timestamp":1555113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p><jats:bold>Background<\/jats:bold>. The use of radiation therapy for the treatment of tumors of the chest \u0441an lead to the development of cardiac pathology,\u00a0including that of the valves and coronary arteries. Study aim: to analyze the specifics of post-radiation lesions of the valvular\u00a0apparatus and coronary arteries, and to assess the immediate results and risks of surgical correction of detected defects. <jats:bold>Materials\u00a0and\u00a0 methods<\/jats:bold>. In the Emergency department of surgery of acquired heart disease of A. N. Bakulev National Medical Research Center\u00a0of Cardiovascular Surgery in the period from 2004 to 2017 were examined and operated 46 patients aged 35\u201381 years (mean\u00a0age 56\u00b112.4 years, 80 % women). The period from primary irradiation of the chest to surgical treatment of valvular pathology\u00a0ranged from 4 to 40 years. Indications for thoracic radiotherapy were Hodgkin\u2019s lymphoma in 23 patients (50 %), breast cancer \u2013\u00a0in 20 (43 %). <jats:bold>Results<\/jats:bold>. Stenosis of the aortic valve was the leading defect in 42 patients (91 %). According to coronary angiography,\u00a0coronary artery disease was diagnosed in 31 patients (67 %). Isolated aortic valve prosthesis was performed in 14 (30 %) patients,\u00a0other operations were combined. Hospital mortality was 11 % (5 patients). There were no deaths among patients who underwent\u00a0radiation therapy after mastectomy. Main nonlethal complications were: pericardial effusion in 6 patients (13 %), hydrothorax requiring\u00a0repeated pleural punctures in 5 patients (11 %). <jats:bold>Conclusion<\/jats:bold>. The variety of clinical manifestations of radiation heart disease\u00a0and its progressive nature emphasize the need for long-term dynamic observation of patients after thoracic irradiation in order\u00a0to timely identify the pathology and eliminate the risk of sudden cardiac complications and the development of severe heart failure\u00a0decompensation.<\/jats:p>","DOI":"10.18087\/cardio.2019.3.10239","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T09:07:35Z","timestamp":1555405655000},"page":"36-42","source":"Crossref","is-referenced-by-count":4,"title":["Post Radiotherapy Lesions of the Heart Valves. Principles of Diagnosis and Results of Treatment"],"prefix":"10.18087","volume":"59","author":[{"given":"R. M.","family":"Muratov","sequence":"first","affiliation":[{"name":"A. N. Bakoulev Scientific Center for Cardiovascular Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. I.","family":"Babenko","sequence":"additional","affiliation":[{"name":"A. N. Bakoulev Scientific Center for Cardiovascular Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Sachkov","sequence":"additional","affiliation":[{"name":"A. N. Bakoulev Scientific Center for Cardiovascular Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. N.","family":"Soboleva","sequence":"additional","affiliation":[{"name":"A. N. Bakoulev Scientific Center for Cardiovascular Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. A.","family":"Andrianova","sequence":"additional","affiliation":[{"name":"A. N. Bakoulev Scientific Center for Cardiovascular Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7442","published-online":{"date-parts":[[2019,4,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Machann W., Beer M., Breunig M. et al. Cardiac magnetic resonance imaging findings in 20-year survivors of mediastinal radiotherapy for Hodgkin\u2019s disease. Int J Radiat Oncol Biol Phys 2010;79(4):1117\u20131123.","DOI":"10.1016\/j.ijrobp.2009.12.054"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"McGale P., Darby S.C., Hallb P. et al. Incidence of heart disease in 35,000 women treated with radiotherapy for breast cancer in Denmark and Sweden. Radiotherapy and Oncology 2011;100(2):167\u2013175.","DOI":"10.1016\/j.radonc.2011.06.016"},{"key":"ref3","unstructured":"Mauch P.M., Kalish L.A., Marcus K.C. et al. Long-term survival in Hodgkin\u2019s disease relative impact of mortality, second tumors, infection, and cardiovascular disease. Cancer J Sci Am 1995;1(1):33\u201342."},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Hoppe R.T. Hodgkin\u2019s disease: complications of therapy and excess mortality. 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Curr Opin Oncol 2001;13:242\u2013248.","DOI":"10.1097\/00001622-200107000-00006"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Siregar S., de Heer F., van Herwerden L.A. Cardiac surgery in patients irradiated for Hodgkin\u2019s lymphoma. Neth Heart J 2010;18(2):61\u201365.","DOI":"10.1007\/BF03091739"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Chang A.S., Smedira N.G., Chang C.L. et al. Cardiac surgery after mediastinal radiation: extent of exposure influences outcome. J Thorac Cardiovasc Surg 2007;133:404\u2013413.","DOI":"10.1016\/j.jtcvs.2006.09.041"}],"container-title":["Kardiologiia"],"original-title":[],"link":[{"URL":"https:\/\/lib.ossn.ru\/jour\/article\/viewFile\/564\/384","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T16:02:23Z","timestamp":1746374543000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardio.elpub.ru\/jour\/article\/view\/564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,13]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,4,13]]}},"URL":"https:\/\/doi.org\/10.18087\/cardio.2019.3.10239","relation":{},"ISSN":["2412-5660","0022-9040"],"issn-type":[{"value":"2412-5660","type":"electronic"},{"value":"0022-9040","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4,13]]}}}