{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:32:06Z","timestamp":1793640726981,"version":"4.5.1"},"reference-count":21,"publisher":null,"issue":"4","license":[{"start":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T00:00:00Z","timestamp":1555545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    : to study myocardial contractile function in patients with liver cirrhosis and ascites in the presence of bacterial overgrowth\u00a0syndrome (BOS) and pathological bacterial translocation.\n                    <jats:bold>Materials and methods<\/jats:bold>\n                    . We included in this study 59 patients\u00a0with Child-Pugh class B and C liver cirrhosis (LC) of various etiology and ascites. Control group comprised 12 patients with\u00a0ischemic heart disease complicated by chronic heart failure (CHF). Examination included history taking and laboratory and\u00a0instrumental investigation. LC was diagnosed basing on clinical symptoms and instrumental studies. Child-Pugh and MELD\u00a0scores were used for assessment of LC severity and prognosis. International ascites club grading system was used for evaluation\u00a0of severity of ascites. Hydrogen breath test was applied for diagnosing BOS. Syndrome of pathological bacterial translocation\u00a0was established based on blood levels of lipopolysaccharide-binding protein and detection of bacterial DNA in ascitic fluid.\u00a0Structural-functional parameters of the myocardium and hemodynamics were assessed by echocardiography. Brain natriuretic\u00a0peptide (BNP) concentration was measured in blood serum and ascitic fluid.\n                    <jats:bold>Results<\/jats:bold>\n                    . In 13 of 59 patients with LC the hydrogen\u00a0breath test was negative, in 33 positive and in 13 patients the positive hydrogen test was combined with the presence of BOS\u00a0and pathological bacterial translocation. Blood serum and ascitic fluid BNP concentrations in LC patients were low and within\u00a0normal limits (62.5\u00b14.1 and 53.3\u00b14.9 rg \/ ml, respectively), what contrasted with high BNP concentrations in patients with\u00a0CHF (1820\u00b195.5 and 497.1\u00b139.6 rg \/ ml, respectively). Total protein level in ascitic fluid also was significantly lower in patients\u00a0with LC than in patients with CHF (1.77\u00b10.1 and 4.43\u00b10.35 mg \/ dL, respectively). The serum-ascitic albumin gradient\u00a0(SAAG) in both groups of patients exceeded 1.1 (1.58\u00b10.13 in patients with CHF and 1.88\u00b10.19 in patients with LC).\u00a0\n                    <jats:bold>Conclusions<\/jats:bold>\n                    . In patients with liver cirrhosis the presence of BOS and bacterial translocation did not produce a distinct negative\u00a0impact on contractile function.\n                  <\/jats:p>","DOI":"10.18087\/cardio.2019.4.10252","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T06:14:14Z","timestamp":1555654454000},"page":"67-73","source":"Crossref","is-referenced-by-count":2,"title":["Myocardial Contractile Function in Patients with Liver Cirrhosis and Syndrome of Bacterial Overgrowth Syndrome"],"prefix":"10.68900","volume":"59","author":[{"given":"K. V.","family":"Ivashkin","sequence":"first","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. N.","family":"Shirokova","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. T.","family":"Ivashkin","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. V.","family":"Plyusnin","sequence":"additional","affiliation":[{"name":"3rd Central Military Clinical Hospital named after A. A. Vishnevsky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Zharkova","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. V.","family":"Maslennikov","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Skhirtladze","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. V.","family":"Maevskaya","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2019,4,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Runyon BA. 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