{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:32:06Z","timestamp":1793640726801,"version":"4.5.1"},"reference-count":72,"publisher":null,"issue":"6","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>Systematic analysis of 3 728 publications on the relationship between microelement status and chronic heart failure (CHF) was carried out. Three main areas of research have been identified: 1) magnesium, electrolytes and CHF; 2) the transcriptional and antioxidant effects of zinc, selenium, copper; 3) iron-deficiency anemia and CHF. In this paper, we consider a complex of relationships between the magnesium insufficiency and CHF, the effect of magnesium on vascular tone, mitochondria, heart rhythm and the susceptibility of cardiomyocytes to adrenergic stimulation. Using magnesium orotate for the treatment of CHF is a feasible approach to compensate magnesium insufficiency in patients with CHF.<\/jats:p>","DOI":"10.18087\/cardio.2019.6.n683","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T03:36:27Z","timestamp":1561606587000},"page":"26-34","source":"Crossref","is-referenced-by-count":4,"title":["Systematic Analysis of the Roles of Trace Elements in the Prevention and Treatment of Chronic Heart Failure"],"prefix":"10.68900","volume":"59","author":[{"given":"O. A.","family":"Gromova","sequence":"first","affiliation":[{"name":"Federal Research Center for Informatics and Management; \r\nCenter for Big Data Storage and Analysis, Moscow State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Yu.","family":"Torshin","sequence":"additional","affiliation":[{"name":"Federal Research Center for Informatics and Management; \r\nCenter for Big Data Storage and Analysis, Moscow State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zh. D.","family":"Kobalava","sequence":"additional","affiliation":[{"name":"Moscow State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. G.","family":"Nazarenko","sequence":"additional","affiliation":[{"name":"N. N. Burdenko National Scientific and Practical Center for Neurosurgery"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2019,6,27]]},"reference":[{"key":"ref1","unstructured":"Gromova O.A., Torshin I.Yu., Kalacheva A.G., Gromov A.N. Clinical and epidemiological studies of coronary heart disease: the role of magnesium deficiency. Pharmateca. 2014;18(291):48\u201359. [Russian]"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Lima LF de, Barbosa F, Sim\u00f5es MV, Navarro AM. Heart failure, micronutrient profile, and its connection with thyroid dysfunction and nutritional status. Clinical Nutrition. 2019;38(2):800\u20135. DOI: 10.1016\/j.clnu.2018.02.030","DOI":"10.1016\/j.clnu.2018.02.030"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Wannamethee SG, Papacosta O, Lennon L, Whincup PH. Serum magnesium and risk of incident heart failure in older men: The British Regional Heart Study. 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Speransky. 2014;93(2):123\u201333. [Russian]"},{"key":"ref37","unstructured":"Gromova O.A., Torshin I.Yu., Yurgel\u2019 I.S. Retrospective of pharmacokinetic studies of magnesium preparations. Difficult patient. 2009;7(6\u20137):42\u20136. [Russian]"},{"key":"ref38","unstructured":"Gromova O.A., Torshin I.Yu., Sardaryan I.S., Gromov A.N., Rudakov K.V. Magnesium orotate preparations in cardiovascular disorders: future directions. Effective pharmacotherapy. 2013;33:52\u201363. [Russian]"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Gromova O.A., Kalacheva A.G., Torshin I.Yu., Grishina T.R., Semenov V.A. Diagnostics of Magnesium Deficiency and Measurements of Magnesium Concentrations in Biosubstrates in Norm and in Various Pathologies. Kardiologiia. 2014;54(10):63\u201371. [Russian]","DOI":"10.18565\/cardio.2014.10.63-71"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Torshin I.Yu., Gromova O.A. 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