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Proceedings of the National Academy of Sciences. 2011;108(23):9613-8. DOI: 10.1073\/pnas.1103187108","DOI":"10.1073\/pnas.1103187108"},{"key":"ref68","doi-asserted-by":"crossref","unstructured":"Persegol L, Darabi M, Dauteuille C, Lhomme M, Chantepie S, Rye K-A et al. Small dense HDLs display potent vasorelaxing activity, reflecting their elevated content of sphingosine-1-phosphate. Journal of Lipid Research. 2018;59(l):25-34. DOI: 10.1194\/jlr.M076927","DOI":"10.1194\/jlr.M076927"},{"key":"ref69","doi-asserted-by":"crossref","unstructured":"Pappu R, Schwab SR, Cornelissen I, Pereira JP, Regard JB, Xu Y et al. Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate. Science. 2007;316(5822):295-8. DOI: 10.1126\/science.1139221","DOI":"10.1126\/science.1139221"},{"key":"ref70","unstructured":"Knapp M, Baranowski M, Czarnowski D, Lisowska A, Zabielski P, Gorski J et al. Plasma sphingosine-1-phosphate concentration is reduced in patients with myocardial infarction. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. 2009;15(9):CR490-493. PMID: 19721401"},{"key":"ref71","doi-asserted-by":"crossref","unstructured":"Hillis GS, Flapan AD. Cell adhesion molecules in cardiovascular disease: a clinical perspective. Heart. 1998;79(5):429-31. DOI: 10.1136\/hrt.79.5.429","DOI":"10.1136\/hrt.79.5.429"},{"key":"ref72","doi-asserted-by":"crossref","unstructured":"Peters S, Alewijnse A. Sphingosine-1-phosphate signaling in the cardiovascular system. Current Opinion in Pharmacology. 2007;7(2):186-92. DOI: 10.1016\/j.coph.2006.09.008","DOI":"10.1016\/j.coph.2006.09.008"},{"key":"ref73","doi-asserted-by":"crossref","unstructured":"Ryo Terao, Megumi Honjo, Makoto Aihara. Apolipoprotein M Inhibits Angiogenic and Inflammatory Response by Sphingosine 1-Phosphate on Retinal Pigment Epithelium Cells. International Journal of Molecular Sciences. 2017;19(1):112. DOI: 10.3390\/ijms19010112","DOI":"10.3390\/ijms19010112"},{"key":"ref74","doi-asserted-by":"crossref","unstructured":"Sattler K, Lehmann I, Graler M, Brocker-Preuss M, Erbel R, Heusch G et al. HDL-Bound Sphingosine 1-Phosphate (S1P) Predicts the Severity of Coronary Artery Atherosclerosis. Cellular Physiology and Biochemistry. 2014;34(1):172-84. DOI: 10.1159\/000362993","DOI":"10.1159\/000362993"},{"key":"ref75","doi-asserted-by":"crossref","unstructured":"Orsoni A, Therond P, Tan R, Giral P, Robillard P, Kontush A et al. Statin action enriches HDL3 in polyunsaturated phospholipids and plasmalogens and reduces LDL-derived phospholipid hydroperoxides in atherogenic mixed dyslipidemia. Journal of Lipid Research. 2016;57(11):2073-87. DOI: 10.1194\/jlr.P068585","DOI":"10.1194\/jlr.P068585"},{"key":"ref76","doi-asserted-by":"crossref","unstructured":"Meikle PJ, Wong G, Tan R, Giral P, Robillard P, Orsoni A et al. Statin action favors normalization of the plasma lipidome in the atherogenic mixed dyslipidemia of MetS: potential relevance to statin-associated dysglycemia. Journal of Lipid Research. 2015;56(12):2381-92. 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