{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:32:19Z","timestamp":1793640739925,"version":"4.5.1"},"reference-count":24,"publisher":null,"issue":"8","license":[{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    to assess cardiac electrophysiological parameters in patients with paroxysmal atrial fibrillation (AF), lone or with concomitant arterial hypertension (AH), and their prognostic significance relative to treatment effectiveness.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and methods<\/jats:bold>\n                    . We included in this study 184 patients with paroxysmal AF (84 with concomitant AH and 100 with presumed lone AF). Cardiac electrophysiological study was performed in accordance with standardized protocol that included assessment of sinus node recovery time, sinoatrial, intraatrial and interatrial conduction time, and effective refractory periods (ERP) of right and left atria and atrioventricular node. Patients with inducible supraventricular reentrant arrhythmias that could potentially trigger AF underwent catheter radiofrequency ablation of those arrhythmias. Other patients received either antiarrhythmic drug therapy (AAD; n=79) or catheter cryo-ablation (CBA; n=81). Treatment was considered ineffective in case of any symptomatic or asymptomatic AF episode documented by ECG or Holter ECG within 12 months of follow-up.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results.<\/jats:bold>\n                    Patients with lone AF compared with those with AH had shorter ERP of the right atrium (219\u00b121 ms vs. 253\u00b144 ms, respectively, p&lt;0.05) and more prominent dispersion of ERP of right and left atria (median 40 ms, interquartile range 10-50 ms vs. median 20 ms, interquartile range 10-22.5 ms, respectively, p&lt;0.05). There was no statistically significant difference in other electrophysiology parameters between the groups. Sustained supraventricular reentrant arrhythmias were induced in 9% (9 of 100) patients with presumed lone AF and in 1.2% (1 of 84) patients with AH (p&lt;0.05). All these arrhythmias were successfully ablated, and patients had no AF recurrence during 12-month follow-up. Among other patient treatment (CBA n=81, AAD n=79) was effective in 64% of those with lone AFib and in 34% - with AH (p&lt;0.05). In multivariate multiple regression analysis, none of electrophysiological parameters could be assumed as a factor associated with the efficacy of CBA or AAD. Conclusion. Patients with lone AF had more prominent atrial electrophysiological inhomogeneity compared with patients with concomitant AH. Cardiac electrophysiological parameters had no influence on effectiveness of antiarrhythmic treatment.\n                  <\/jats:p>","DOI":"10.18087\/cardio.2019.8.n644","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T06:13:20Z","timestamp":1565331200000},"page":"39-46","source":"Crossref","is-referenced-by-count":7,"title":["Electrophysiological Cardiac Parameters and Results of Antiarrhythmic Treatment in Patients with Paroxysmal Atrial Fibrillation (Lone and Associated with Arterial Hypertension)"],"prefix":"10.68900","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1971-1895","authenticated-orcid":true,"given":"E. S.","family":"Mironova","sequence":"first","affiliation":[{"name":"National Medical Research Center in Cardiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6086-6784","authenticated-orcid":true,"given":"N. Yu.","family":"Mironov","sequence":"additional","affiliation":[{"name":"National Medical Research Center in Cardiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2374-3718","authenticated-orcid":true,"given":"N. A.","family":"Mironova","sequence":"additional","affiliation":[{"name":"National Medical Research Center in Cardiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4498-7540","authenticated-orcid":true,"given":"Peter Sergeevich","family":"Novikov","sequence":"additional","affiliation":[{"name":"National Medical Research Center in Cardiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0716-728X","authenticated-orcid":true,"given":"I. A.","family":"Novikov","sequence":"additional","affiliation":[{"name":"National Medical Research Center in Cardiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3102-1686","authenticated-orcid":true,"given":"Lada Yurievna","family":"Layovich","sequence":"additional","affiliation":[{"name":"National Medical Research Center in Cardiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2989-9366","authenticated-orcid":true,"given":"Evgeny Borisovich","family":"Maykov","sequence":"additional","affiliation":[{"name":"National Medical Research Center in Cardiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9913-9974","authenticated-orcid":true,"given":"Sergey Pavlovich","family":"Golitsyn","sequence":"additional","affiliation":[{"name":"National Medical Research Center in Cardiology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2019,8,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC et al. 2014 AHA\/ACC\/HRS Guideline for the Management of Patients With Atrial Fibrillation: Executive Summary: A Report of the American College of Cardiology\/ American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. Circulation. 2014;130(23):2071-104. DOI: 10.1161\/CIR.0000000000000040","DOI":"10.1161\/CIR.0000000000000040"},{"key":"ref2","unstructured":"Sulimov V.A., Golitsyn S.P., Blagova O.V., Nedostup A.V. Diagnostics and management of atrial fibrillation recommendations RSC, RSSA and ACVS. Rational Pharmacotherapy in Cardiology. 2011;7(4):5-84."},{"key":"ref3","unstructured":"Revishvili A. Sh., Shlyakhto E. V., Sulimov V. A., Rzaev F. G., Gorev M. V., Nardaya Sh. G. et al. Recommendations RKO, VNOA and ASSH \u201cDiagnosis and treatment of atrial fibrillation\" 2017."},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Goette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA et al. EH^A\/HRS\/APHRS\/SOLAECE expert consensus on Atrial cardiomyopathies: Definition, characterisation, and clinical implication. Journal of Arrhythmia. 2016;32(4):247-78. DOI: 10.1016\/j.joa.2016.05.002","DOI":"10.1016\/j.joa.2016.05.002"},{"key":"ref5","unstructured":"Revishvili A.Sh., Rzaev F.G., Djordjikiya T.R., Lyubkina E.V., Aleksandrova S.A., Sopov O.V. Atrial fibrillation in young patients. Annals of Arrhythmology. 2007;4(3):22-8."},{"key":"ref6","unstructured":"Mironov N.Yu., Golitsyn S.P., Sokolov S.F., Maikov E.B., Shlevkov N.B., Yuricheva Yu.A. et al. Electrophysiological Effects and Antiarrhythmic Activity of Novel Domestic Class III Antiarrhythmogenic Drug Niferidil Administered in Patients with Paroxismal Supraventricular Tachycardia. Experimental and Clinical Pharmacology. 2012;75(10):16-21."},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Narula OS, Samet P, Javier RP. Significance of the sinus-node recovery time. Circulation. 1972;45(1):140-58. PMID: 4108657","DOI":"10.1161\/01.CIR.45.1.140"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Boytsov SA, Demkina AE, Oshchepkova EV, Dolgusheva YuA. Progress and Problems of Practical Cardiology in Russia at the Present Stage. Kardiologiia. 2019;59(3):53-9. DOI: 10.18087\/cardio.2019.3.10242","DOI":"10.18087\/cardio.2019.3.10242"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Zhernakova Yu.V., Zheleznova E.A., Chazova I.E., Oshchepkova E.V., Dolgusheva Yu.A., Yarovaya E.B. et al. The prevalence of abdominal obesity and the association with socioeconomic status in Regions of the Russian Federation, the results of the epidemiological study - ESSE-RF. Therapeutic Archive. 2018;90(10):14-22. DOI: 10.26442\/terarkh201890104-22","DOI":"10.26442\/terarkh201890104-22"},{"key":"ref10","unstructured":"Rashbaeva G.S., Revishvili A.Sh. Surgical and endovascular management of lone atrial fibrillation. Journal of Arrhythmology. 2011;63:55-60."},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Tarasov A.V., Davtyan K.V., Shatakhtsyan V.S. An effectiveness of antiarrhythmic therapy for different types of recurrent atrial tachyarrhythmia in early postoperative period after catheter isolation of pulmonary veins. Cardiology and cardiovascular surgery. 2017;10(2):70-7. DOI: 10.17116\/kardio201710270-77","DOI":"10.17116\/kardio201710270-77"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Valiakhmetov M.N., Gomova T.A., Loukianov M.M., Martsevich S.Yu., Nadejkina K.N., Artemova M.N. et al. Patients with Atrial Fibrillation in Multidisciplinary Hospital: Structure of Hospitalization, Concomitant Cardiovascular Diseases and Drug Treatment (Data of RECVASA AF-Tula Registry). Rational Pharmacotherapy in Cardiology. 2017;13(4):495-505. DOI: 10.20996\/1819-6446-2017-13-4-495-505","DOI":"10.20996\/1819-6446-2017-13-4-495-505"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Loukianov M.M., Boytsov S.A., Yakushin S.S., Martsevich S. Yu., Vorobyev A.N., Zagrebelnyy A.V. et al. Diagnostics, treatment, associated cardiovascular and concomitant non-cardiac diseases in patients with diagnosis of \u201catrial fibrillation\" in real outpatient practice (according to data of registry of cardiovascular diseases, RECVASA). Rational Pharmacotherapy in Cardiology. 2014;10(4):366-77. DOI: 10.20996\/1819-6446-2014-10-4-366-377","DOI":"10.20996\/1819-6446-2014-10-4-366-377"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Akramova E.G . Ultrasonic indicators of the heart and carotid arteries in arterial hypertension development in patients with chronic obstructive pulmonary disease. Kazan medical journal. 2016;97(4):496-501. DOI: 10.17750\/KMJ2015-496","DOI":"10.17750\/KMJ2015-496"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Blinova N.V., Zhernakova Yu.V., Chazova I.E., Oshchepkova E.V. \u04221\u0430\u0435 patients \u043ef high cardiovascular risk of healthy: unrecognized metabolic syndrome. Systemic Hypertension. 2016;13(4):60-5.","DOI":"10.26442\/2075-082X_13.4.60-65"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Khidirova L.D., Yakhontov D.A., Zenin S.A. Arterial hypertension in combination with atrial fibrillation and extracardiac diseases. Kazan medical journal. 2018;99(6):894-9. DOI: 10.17816\/KMJ2018-894","DOI":"10.17816\/KMJ2018-894"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Manolis AJ, Rosei EA, Coca A, Cifkova R, Erdine SE, Kjeldsen S et al. Hypertension and atrial fibrillation: diagnostic approach, prevention and treatment. Position paper of the Working Group 'Hypertension Arrhythmias and Thrombosis' of the European Society ofHypertension.Journal ofHypertension. 2012;30(2):239-52. DOI: 10.1097\/HJH.0b013e32834f03bf","DOI":"10.1097\/HJH.0b013e32834f03bf"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Akramova E.G. Clinical significance of left ventricular longitudinal deformation in coronary heart disease and non-coronary pathology. Kazan medical journal. 2019;100(2):295-302. DOI: 10.17816\/KMJ2019-295","DOI":"10.17816\/KMJ2019-295"},{"key":"ref19","unstructured":"Yakhontov D.A., Zenin S.A., Khidirova L.D., Kireeva O.V. Atrial fibrillation and arterial hypertension associated with non-coronarogenic origin deseases. Journal of Siberian Medical Sciences. 2018;1:4-10."},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Manninger M, Zweiker D, van Hunnik A, Alogna A, Prassl AJ, Schipke J et al. Arterial hypertension drives arrhythmia progression via specific structural remodeling in a porcine model of atrial fibrillation. Heart Rhythm. 2018;15(9):1328-36. DOI: 10.1016\/j.hrthm.2018.05.016","DOI":"10.1016\/j.hrthm.2018.05.016"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Allessie M, Ausma J, Schotten U. Electrical, contractile and structural remodeling during atrial fibrillation. Cardiovascular Research. 2002;54(2):230-46. DOI: 10.1016\/s0008-6363(02)00258-4","DOI":"10.1016\/S0008-6363(02)00258-4"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Yu WC, Lee SH, Tai CT, Tsai CF, Hsieh MH, Chen CC et al. Reversal of atrial electrical remodeling following cardioversion of long-standing atrial fibrillation in man. Cardiovascular Research. 1999;42(2):470-6. DOI: 10.1016\/s0008-6363(99)00030-9","DOI":"10.1016\/S0008-6363(99)00030-9"},{"key":"ref23","unstructured":"Artyukhina E.A., Yashkov M.V., Vaskovsky V.A., Revishvili A.Sh. Radiofrequency ablation of arrhythmogenic foci in the right atrium of patients with atrial fibrillation. Journal of Arrhythmology. 2018;91:44-7."},{"key":"ref24","unstructured":"Rodionova E.S., Mironova N.A., Aparina O.P., Rogova M.M., Zykov K.A., Golytsyn S.P. Role of autoimmune reactions in development of cardiac arrhythmia and conduction disturbances. Therapeutic Archive. 2012;84(4):74-8."}],"container-title":["Kardiologiia"],"original-title":[],"link":[{"URL":"https:\/\/lib.ossn.ru\/jour\/article\/viewFile\/644\/475","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:17:23Z","timestamp":1793639843000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardio.elpub.ru\/jour\/article\/view\/644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,8]]},"references-count":24,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,8]]}},"URL":"https:\/\/doi.org\/10.18087\/cardio.2019.8.n644","relation":{},"ISSN":["2412-5660","0022-9040"],"issn-type":[{"value":"2412-5660","type":"electronic"},{"value":"0022-9040","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8,8]]}}}