{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:32:11Z","timestamp":1793640731444,"version":"4.5.1"},"reference-count":21,"publisher":null,"issue":"12","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>\n                    <jats:italic>Aim\u00a0\u00a0\u00a0\u00a0\u00a0<\/jats:italic>\n                    To determine the type and incidence of ictal bradyarrhythmias in patients with drug-resistant types of epilepsy by long-term electrocardiogram (ECG) monitoring.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Material and methods\u00a0<\/jats:italic>\n                    Subcutaneous ECG monitors programed for recording pauses &gt;3\u2008sec and episodes of bradycardia \u226445 bpm were implanted in 193 patients with persistent epileptic seizures without organic pathology of the myocardium. Recording was activated by the patient\/family at the onset of epileptic seizure. The follow-up period was 36 months with visits to the clinic every three months.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    For 36 months of monitoring, 6494 ECG fragments were recorded. Ictal bradycardia was observed in 6.7\u200a% of patients, including ictal asystole in 2.6\u200a% of patients. Episodes of bradycardia and asystole during epileptic seizures were transient and developed significantly more frequently in men, patients with long duration of the disease, bilateral tonic-clonic or focal seizures with disorder of consciousness, during sleep, on the background of treatment with several antiepileptic agents, mostly from the group of potassium channel blockers.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion\u00a0\u00a0\u00a0\u00a0\u00a0<\/jats:italic>\n                    Bradyarrhythmias accompanying epileptic seizures are transient and reproducible from seizure to seizure. They reflect functional changes in the myocardium and do not determine the life prediction for patients with epilepsy without organic pathology of the heart.\n                  <\/jats:p>","DOI":"10.18087\/cardio.2020.12.n1379","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T07:55:17Z","timestamp":1612166117000},"page":"90-96","source":"Crossref","is-referenced-by-count":1,"title":["\u201cIctal\u201d Bradyarrhythmias in Patients with Drug-Resistant Epilepsy: Results of Long-Term Heart Rhythm Monitoring"],"prefix":"10.68900","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4479-6963","authenticated-orcid":true,"given":"S. E.","family":"Serdyuk","sequence":"first","affiliation":[{"name":"National Medical Research Center for Therapy and Preventive Medicine, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3788-3997","authenticated-orcid":true,"given":"K. V.","family":"Davtyan","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Therapy and Preventive Medicine, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0804-7076","authenticated-orcid":true,"given":"S. G.","family":"Burd","sequence":"additional","affiliation":[{"name":"Neurosurgery and Medical Genetics, Pirogov Russian Research Medical University, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. S.","family":"Mishina","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Therapy and Preventive Medicine, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4453-8430","authenticated-orcid":true,"given":"O. M.","family":"Drapkina","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Preventive Medicine, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0742-6875","authenticated-orcid":true,"given":"E. I.","family":"Gusev","sequence":"additional","affiliation":[{"name":"Neurosurgery and Medical Genetics, Pirogov Russian Research Medical University, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Feigin VL, Nichols E, Alam T, Bannick MS, Beghi E, Blake N et al. Global, regional, and national burden of neurological disorders, 1990\u2013 2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology. 2019;18(5):459\u201380. 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