{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:31:13Z","timestamp":1793640673071,"version":"4.5.1"},"reference-count":6,"publisher":null,"issue":"3","license":[{"start":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T00:00:00Z","timestamp":1588464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>Transthyretin amyloidosis (ATTR) is a threatening and severe genetic disease characterized by damages to organs and systems caused by a pathological protein transthyretin produced in the liver. Clinical manifestations of this disease vary from injuries of the nervous system to injuries of the cardiovascular system. Prognosis for ATTR-amyloidosis remains unfavorable. The absence of pathognomonic symptoms complicates diagnostics of this disease, which tends to simulate other conditions. At present, medicines exist, which are pathogenetic in the treatment of ATTR-amyloidosis. The article describes a clinical case of ATTR-amyloidosis with primary heart injury complicated with functional class III chronic heart failure during the tafamidis treatment.<\/jats:p>","DOI":"10.18087\/cardio.2020.3.n824","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T04:01:32Z","timestamp":1588824092000},"page":"155-160","source":"Crossref","is-referenced-by-count":4,"title":["Experience with tafamidis in a patient with transthyretin amyloidosis"],"prefix":"10.68900","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0920-7417","authenticated-orcid":true,"given":"S. N.","family":"Nasonova","sequence":"first","affiliation":[{"name":"Federal State Budgetary Institution National Medical Cardiology Research Center of the Ministry of Health of the Russian Federation, Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4066-2661","authenticated-orcid":true,"given":"I. V.","family":"Zhirov","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution National Medical Cardiology Research Center of the Ministry of Health of the Russian Federation, Moscow, Russian Federation\r\n\r\nFederal State Budgetary Educational Institution of Continuing Professional Education Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation, Department of Cardiology, Moscow, Russian Federation."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4701-404X","authenticated-orcid":true,"given":"M. M.","family":"Magomedov","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution National Medical Cardiology Research Center of the Ministry of Health of the Russian Federation, Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3233-1862","authenticated-orcid":true,"given":"M. A.","family":"Saidova","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution National Medical Cardiology Research Center of the Ministry of Health of the Russian Federation, Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7827-2618","authenticated-orcid":true,"given":"Yu. F.","family":"Osmolovskaya","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution National Medical Cardiology Research Center of the Ministry of Health of the Russian Federation, Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9234-6129","authenticated-orcid":true,"given":"S. N.","family":"Tereschenko","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution National Medical Cardiology Research Center of the Ministry of Health of the Russian Federation, Moscow, Russian Federation\r\n\r\nFederal State Budgetary Educational Institution of Continuing Professional Education Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation, Department of Cardiology, Moscow, Russian Federation."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2020,5,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Witteles RM, Bokhari S, Damy T, Elliott PM, Falk RH, Fine NM et al. Screening for Transthyretin Amyloid Cardiomyopathy in Everyday Practice. JACC: Heart Failure. 2019;7(8):709\u201316. DOI: 10.1016\/j.jchf.2019.04.010","DOI":"10.1016\/j.jchf.2019.04.010"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Rapezzi C, Riva L, Quarta CC, Perugini E, Salvi F, Longhi S et al. Gender-related risk of myocardial involvement in systemic amyloidosis. Amyloid. 2008;15(1):40\u20138. DOI: 10.1080\/13506120701815373","DOI":"10.1080\/13506120701815373"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Rameeva A.S., Rameev V.V., Moiseev S.V., Tao P.P., Kozlovskaya L.V. Amyloid heart disease: pathomorphology, diagnostic approa\u00adches and treatment options. Consilium Medicum. 2018;20(12): 15\u201322. [Russian: Rameeva A. S., Rameev V. V., Moiseev S. V., Tao P. P., Kozlovskaya L. V. Amiloidnaya kardiopatiya: patomorfologiya, metody diagnostiki i lecheniya. Consilium Medicum. 2018;20(12):15\u201322]. DOI: 10.26442\/20751753.2018.12.000020","DOI":"10.26442\/20751753.2018.12.000020"},{"key":"ref4","unstructured":"Roberts JR, Lan ML. Transthyretin-Related Amyloidosis: Practice Essentials, Background, Pathophysiology. Medscape. 2018; [Av. at https:\/\/emedicine.medscape.com\/article\/335301-overview#a2]"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Sun JP, Stewart WJ, Yang XS, Donnell RO, Leon AR, Felner JM et al. Differentiation of Hypertrophic Cardiomyopathy and Cardiac Amyloidosis from Other Causes of Ventricular Wall Thickening by Two-Dimensional Strain Imaging Echocardiography. The American Journal of Cardiology. 2009;103(3):411\u20135. DOI: 10.1016\/j.amjcard.2008.09.102","DOI":"10.1016\/j.amjcard.2008.09.102"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Bhogal S, Ladia V, Sitwala P, Cook E, Bajaj K, Ramu V et al. Cardiac Amyloidosis: An Updated Review with Emphasis on Diagnosis and Future Directions. Current Problems in Cardiology. 2018;43(1): 10\u201334. 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