{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:32:04Z","timestamp":1793640724060,"version":"4.5.1"},"reference-count":12,"publisher":null,"issue":"6","license":[{"start":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T00:00:00Z","timestamp":1591142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>\n                    <jats:italic>Aim<\/jats:italic>\n                    To evaluate incidence of arterial hypertension (AH) in the posttransplantation period and to identify risk factors for this complication.\n                    <jats:italic>Materials and methods<\/jats:italic>\n                    From January, 2010 through December, 2017, 96 heart transplantations (HT) (70 men and 26 women aged 46.5\u00b113.9 years) were performed. During the first month following HT, 8 recipients died and were excluded from the analysis. The retrospective evaluation of results included 88 patients followed up for more than one year.\n                    <jats:italic>Results<\/jats:italic>\n                    For the entire post-HT period (maximum 92 months), AH was observed in 75 of 88 (85%) recipients. Post-HT AH was correlated with male gender (r=0.24; p=0.031), history of smoking before HT (r=0.45; p&lt;0.001), history of ischemic heart disease (IHD) (r=0.28; p=0.01), older age (r=0.35; p=0.001), higher body weight index (r=0.37; p=0.0005), creatinine level (r=0.37; p=0.001), and low-density lipoprotein cholesterol level (r=0.27; p=0.04). Interrelations with other AH risk factors were not found. Most patients developed AH within the first two years after HT. During the first year, AH was diagnosed in 60% (53 of 88) of patients (relapse, 85% (n=29); newly diagnosed, 45% (n=24), p=0.0003). At two years, AH was detected in 79% (46 of 58) of patients (relapse, 53% (n=18); newly diagnosed, 53% (n=28), p=0.9). All recipients received an adequate antihypertensive therapy. 40-63% of patients required a single-drug therapy at different points of follow-up; from 29 to 45% of patients required a two-drug therapy, and 5-15% of patients required three or more drugs. During all 5 years of treatment, most patients used angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs) (70-87%) and slow calcium channel blockers (SCCB) (48-53%). The presence of AH following HT was associated with development of all cardiovascular events (CVE; r=0.31; p=0.012) whereas persistent AH, which required a combination antihypertensive treatment, was associated with a high mortality (r=0.61; p=0.015).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    AH is a frequent complication of HT (85%), which is newly diagnosed in most patients during the first two years. AH incidence was higher for male recipients with a history of IHD, hypertension, and smoking. Approximately half of patients required only a single-drug antihypertensive therapy. After HT, the most frequently prescribed drugs included ACE inhibitors or ARBs and SCCBs (70-87% and 48-53%, respectively, depending on the time elapsed after HT). Persistent AH requiring a treatment with two or more antihypertensive drugs was associated with development of all CVEs and a higher long-term mortality.\n                  <\/jats:p>","DOI":"10.18087\/cardio.2020.6.n880","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T06:23:16Z","timestamp":1595917396000},"page":"53-57","source":"Crossref","is-referenced-by-count":0,"title":["Arterial hypertension after heart transplantation"],"prefix":"10.68900","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3228-1188","authenticated-orcid":true,"given":"M. A.","family":"Simonenko","sequence":"first","affiliation":[{"name":"Federal State Budgetary Institution \u00abV.A. Almazov National Medical Research Centre\u00bb of the Min-istry of Health of the Russian Federation, Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7452-1971","authenticated-orcid":true,"given":"P. A.","family":"Fedotov","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u00abV.A. Almazov National Medical Research Centre\u00bb of the Min-istry of Health of the Russian Federation, Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7825-3513","authenticated-orcid":true,"given":"Yu. V.","family":"Sazonova","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u00abV.A. Almazov National Medical Research Centre\u00bb of the Min-istry of Health of the Russian Federation, Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9694-7850","authenticated-orcid":true,"given":"M. A.","family":"Bortsova","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u00abV.A. Almazov National Medical Research Centre\u00bb of the Min-istry of Health of the Russian Federation, Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0139-5177","authenticated-orcid":true,"given":"M. Yu.","family":"Sitnikova","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u00abV.A. Almazov National Medical Research Centre\u00bb of the Min-istry of Health of the Russian Federation, Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5398-5665","authenticated-orcid":true,"given":"M. A.","family":"Karpenko","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u00abV.A. Almazov National Medical Research Centre\u00bb of the Min-istry of Health of the Russian Federation, Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. N.","family":"Belyaeva","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u00abV.A. Almazov National Medical Research Centre\u00bb of the Ministry of Health of the Russian Federation, Saint-Petersburg, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3235-4850","authenticated-orcid":true,"given":"G. V.","family":"Nikolaev","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u00abV.A. Almazov National Medical Research Centre\u00bb of the Min-istry of Health of the Russian Federation, Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8199-0813","authenticated-orcid":true,"given":"M. L.","family":"Gordeev","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u00abV.A. Almazov National Medical Research Centre\u00bb of the Min-istry of Health of the Russian Federation, Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2020,6,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Khush KK, Cherikh WS, Chambers DC, Goldfarb S, Hayes D, Kucheryavaya AY et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-fifth Adult Heart Transplantation Report-2018; Focus Theme: Multiorgan Transplantation. The Journal of Heart and Lung Transplantation. 2018;37(10):1155\u2013206. DOI: 10.1016\/j.healun.2018.07.022","DOI":"10.1016\/j.healun.2018.07.022"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Souza-Neto J, Oliveira I, Lima-Rocha H, Oliveira-Lima J, Bacal F. Hypertension and arterial stiffness in heart transplantation patients. Clinics. 2016;71(9):494\u20139. 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DOI: 10.15825\/1995-1191-2017-3-33-39","DOI":"10.15825\/1995-1191-2017-3-33-39"}],"container-title":["Kardiologiia"],"original-title":[],"link":[{"URL":"https:\/\/lib.ossn.ru\/jour\/article\/viewFile\/880\/715","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:16:43Z","timestamp":1793639803000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardio.elpub.ru\/jour\/article\/view\/880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,3]]},"references-count":12,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6,3]]}},"URL":"https:\/\/doi.org\/10.18087\/cardio.2020.6.n880","relation":{},"ISSN":["2412-5660","0022-9040"],"issn-type":[{"value":"2412-5660","type":"electronic"},{"value":"0022-9040","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6,3]]}}}