{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:32:15Z","timestamp":1793640735033,"version":"4.5.1"},"reference-count":18,"publisher":null,"issue":"7","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    Thromboembolic events such as acute coronary syndrome related prosthetic heart valve thrombosis, pulmonary artery embolism and renal artery embolism are a rare condition but a major cause of morbidity and mortality. In this study we discussed low-dose thrombolytic therapy, in patients with thromboembolic events in the intensive care unit.\n                    <jats:italic>Methods<\/jats:italic>\n                    The study was performed on 12 consecutive patients [8 female; 50.3\u00b116.0 (35\u201395) years] with acute thromboembolism including acute coronary syndrome related prosthetic heart valve thrombosis, acute pulmonary embolism and acute renal embolism who were treated with low-dose (25 mg) and slow infusion (6 hours) of t-PA. We evaluated mainly in-hospital safety and also effectiveness.Total treatment episodes was 1.66\u00b10.88 (1-4) times.\n                    <jats:italic>Results<\/jats:italic>\n                    All thromboembolic events have been successfully treated with low-dose (25 mg) and slow infusion (6 hours) of t-PA. The success criteria were clinically improvement and radiologically lysis. None of the patients had ischemic stroke, intracranial hemorrhage, embolism (peripheral and recurrence of coronary artery embolism), bleeding requiring transfusion. The most frequent in-hospital complication was a gum bleeding without need for transfusion (two patients).\n                    <jats:italic>Conclusions<\/jats:italic>\n                    In our case series low-dose (25 mg) and slow infusion (6 hours) of t-PA have been performed successfully for thromboembolic events including acute coronary syndrome related prosthetic heart valve thrombosis, pulmonary embolism and renal embolism in patients with in the intensive care unit. Safety is promising and if efficacy will be proved; this method may be a valuable alternative to standard fibrinolytic regimen.\n                  <\/jats:p>","DOI":"10.18087\/cardio.2020.7.n1091","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T09:30:18Z","timestamp":1604655018000},"page":"86-90","source":"Crossref","is-referenced-by-count":2,"title":["Safety of low-dose prolonged infusion of tissue plasminogen activator therapy in patients with thromboembolic events in the intensive care unit"],"prefix":"10.68900","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6569-3827","authenticated-orcid":true,"given":"Mehmet Emin","family":"Kalkan","sequence":"first","affiliation":[{"name":"University of Health Sciences Turkey, Mehmet Akif Ersoy Cardiovascular\r\nand Thoracic Surgery Educational and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3502-4785","authenticated-orcid":true,"given":"Mustafa","family":"Yildiz","sequence":"additional","affiliation":[{"name":"University of Health Sciences Turkey, Mehmet Akif Ersoy Cardiovascular\r\nand Thoracic Surgery Educational and Research Hospital, Istanbul, Turkey\r\nIstanbul University-Cerrahpasa Cardiology Institute, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hulya Yilmaz","family":"Ak","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa Cardiology Institute, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hicaz","family":"Zencirkiran Agus","sequence":"additional","affiliation":[{"name":"University of Health Sciences Turkey, Mehmet Akif Ersoy Cardiovascular\r\nand Thoracic Surgery Educational and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"Ozsahin","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa Cardiology Institute, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Cagri","family":"Aykan","sequence":"additional","affiliation":[{"name":"Kahramanmaras Sutcu Imam University Medical Faculty, Kahramanmaras, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dogac","family":"Oksen","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa Cardiology Institute, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2020,6,19]]},"reference":[{"key":"ref1","unstructured":"Rutsch W, Schmutzler H. t-PA in thrombolytic therapy of acute myocardial infarct. Herz. 1994;19(6):336\u201352. PMID: 7843690"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Konstantinides SV, Torbicki A, Agnelli G, Danchin N, Fitzmaurice D, Gali\u00e8 N et al. 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism. European Heart Journal. 2014;35(43):3033\u201380. DOI: 10.1093\/eurheartj\/ehu283","DOI":"10.1093\/eurheartj\/ehu283"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Koivuviita N, Tertti R, Heiro M, Manner I, Mets\u00e4rinne K. Thromboembolism as a Cause of Renal Artery Occlusion and Acute Kidney Injury: The Recovery of Kidney Function after Two Weeks. Case Reports in Nephrology and Dialysis. 2014;4(1):82\u20137. DOI: 10.1159\/000362538","DOI":"10.1159\/000362538"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"\u00d6zkan M, G\u00fcnd\u00fcz S, Biteker M, Astarcioglu MA, \u00c7evik C, Kaynak E et al. Comparison of Different TEE-Guided Thrombolytic Regimens for Prosthetic Valve Thrombosis. 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DOI: 10.1097\/MBC.0b013e328355e86d","DOI":"10.1097\/MBC.0b013e328355e86d"}],"container-title":["Kardiologiia"],"original-title":[],"link":[{"URL":"https:\/\/lib.ossn.ru\/jour\/article\/viewFile\/1091\/762","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:17:40Z","timestamp":1793639860000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardio.elpub.ru\/jour\/article\/view\/1091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,19]]},"references-count":18,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,6,19]]}},"URL":"https:\/\/doi.org\/10.18087\/cardio.2020.7.n1091","relation":{},"ISSN":["2412-5660","0022-9040"],"issn-type":[{"value":"2412-5660","type":"electronic"},{"value":"0022-9040","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6,19]]}}}