{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:32:32Z","timestamp":1793640752618,"version":"4.5.1"},"reference-count":17,"publisher":null,"issue":"7","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/lib.ossn.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kardiologiia"],"abstract":"<jats:p>\n                    <jats:italic>Aim<\/jats:italic>\n                    \u00a0\u00a0\u00a0\u00a0\u00a0 An attempt to prevent the development of diastolic dysfunction (DD) with the mitochondrial antioxidant plastomitin on a model of doxorubicin-induced cardiomyopathy. DD is a type of chronic heart failure. Due to the increasing number of patients with this condition and the absence of effective therapy, development of means for DD correction is a relevant objective.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Material and methods\u00a0<\/jats:italic>\n                    Cardiomyopathy was modeled in 17 rats by two subcutaneous injections of doxorubicin 2 mg\/kg\/week. The other group (n=17), also administered with doxorubicin, received plastomicin 0.32 mg\/kg daily subcutaneously. Left ventricular function was evaluated with echocardiography (EchoCG) and cardiac catheterization with simultaneous pressure and volume monitoring.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    According to EchoCG data the ejection fraction remained unchanged in the experimental groups. Cardiac catheterization showed disorders of both myocardial contractility and relaxability only in the doxorubicin group.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    \u00a0\u00a0\u00a0\u00a0\u00a0 A course of plastomitin in combination with the doxorubicin treatment can maintain normal heart contractility and thereby, prevent the known doxorubicin cardiotoxicity.\n                  <\/jats:p>","DOI":"10.18087\/cardio.2020.7.n1157","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T09:30:18Z","timestamp":1604655018000},"page":"98-102","source":"Crossref","is-referenced-by-count":3,"title":["Prevention of Diastolic Dysfunction Caused by Doxorubicin by Mitochondrial Antioxidant Plastomitin"],"prefix":"10.68900","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5155-7699","authenticated-orcid":true,"given":"V. 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V.","family":"Prosvirnin","sequence":"additional","affiliation":[{"name":"National Medical Research Center of Cardiology, Ministry of Healthcare Russian Federation, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3096-7434","authenticated-orcid":true,"given":"V. I.","family":"Kapelko","sequence":"additional","affiliation":[{"name":"National Medical Research Center of Cardiology, Ministry of Healthcare Russian Federation, Moscow"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2020,6,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Li S, Gupte AA. The Role of Estrogen in Cardiac Metabolism and Diastolic Function. Methodist DeBakey Cardiovascular Journal. 2017;13(1):4\u20138. DOI: 10.14797\/mdcj-13-1-4","DOI":"10.14797\/mdcj-13-1-4"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Mitry MA, Edwards JG. 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